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Alternative structural projections:

Sp-5,6-DCl-cBIMPS

5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-5,6-DCl-cBIMPS ), sodium salt
Powerful PDE-resistant and membrane-permeant PKA agonist
Cat. No.: D 014
    
CAS No.: [120912-54-1]
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Product Name Price (net) Qty
Cat. No.: D 014-05
Unit: 5 µmol / ~2.1 mg
$176.00
For other salt forms please inquire. Potent site-selective activator of cAMP- dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian PDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency. The corresponding Rp- isomer is available as well (Cat. No. D 013). Detailed technical information and updated reference list available. References: Sandberg et al., Biochemistry, 279, 521 - 527 (1991); Maronde et al., J. Pineal Res., 27, 170 - 182 (1999); Poppe et al., Nature Methods, 5, 277 - 278 (2008).
Cat. No. D 014
CAS number [120912-54-1]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₀Cl₂N₂O₅PS · Na
Molecular weight [g/mol] 419,2
Modifications 1-cAMP, 2-cAMP, 3-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.99
Absorption max [nm] 254
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 6400
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