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Alternative structural projections:

Sp-2-Cl-cAMPS

2- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-Cl-cAMPS ), sodium salt
Cat. No.: C 074
    
CAS No.: [124854-63-3]
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Product Name Price (net) Qty
Cat. No.: C 074-05
Unit: 5 µmol
$250.00
For other salt forms please inquire. Analogue of the protein kinase A activator Sp-cAMPS (Cat. No. A003) with increased lipophilicity and phosphodiesterase stability. The halogen in position 2 of the adenine nucleobase can be used for various substitutions including spacers and labels. Detailed technical information available. References: Ruchaud et al., Cell. Pharmacol., 2, 127 - 140 (1995); Yokozaki et al., Cancer Res., 52, 2504 - 2508 (1992).
Cat. No. C 074
CAS number [124854-63-3]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₀ClN₅O₅PS · Na
Molecular weight [g/mol] 401,7
cAMP modified at the exocyclic oxygen axial (Sp-)
Modifications 2-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.64
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
  • 1. Ruchaud S., Zorn M., Davilar-Villar E., Genieser H.-G., Hoffmann C., Gjertsen B. T., Doeskeland S. O., Jastorff B.Lanotte M., Cell. Pharmacol., 2, 127 - 140 (1995), "Evidence for Several Pathways of Biological Response to Hydrolysable cAMP-Analogues Using a Model System of Apoptosis in IPC-81 Leukaemia Cells"
  • 2. Yokozaki H., Tortora G., Pepe S., Maronde E., Genieser H.-G., Jastorff B.Cho- Chung Y. S., Cancer Res., 52, 2504 - 2508 (1992), "Unhydrolysable Analogs of Cyclic Adenosine- 3', 5' - Monophosphate Demonstrating Growth Inhibition and Differentiation in Human Cancer Cells"