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Alternative structural projections:

Sp-2'-AHC-cGMPS

2'- (6- Aminohexyl)carbamoylguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-AHC-cGMPS )
PDE-resistant Sp-cGMPS functionalized for immobilization or conjugation with markers and dyes
Cat. No.: A 067
    
CAS No.: [1262749-61-0]
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Product Name Price (net) Qty
Cat. No.: A 067-05
Unit: 5 µmol / ~2.5 mg
$204.00
PDE-stable cyclic GMP analogue suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling structures including fluorophores. This structure is also offered as a ligand immobilized to agarose (Cat. No. A 052), and without sulfur modification (A 048). Detailed technical information available. Compare: Corrie et al., Prot. Expr. Purif., 3, 417 - 420 (1992).
Cat. No. A 067
CAS number [1262749-61-0]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₂₆N₇O₇PS
Molecular weight [g/mol] 503,5
Modifications 2'-cGMP
Lipophilicity 1.46
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
  • 1. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 2. Corrie J. E. T., Pizza C., Makwana J.King R. W., Prot. Express. Purif., 3, 417 - 420 (1992), "Preparation and Properties of an Affinity Support for Purification of Cyclic AMP Receptor Protein from Escherichia coli"