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Sp-2'-AEC-cAMPS-Agarose

2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel ( Sp-2'-AEC-cAMPS-Agarose )
PDE-resistant Sp-cAMPS immobilized on agarose gel
Cat. No.: A 122
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 122-06
Unit: 0.6 ml
$182.00
Cat. No.: A 122-25
Unit: 2.5 ml
$568.00
Cat. No.: A 122-60
Unit: 6 ml
$1,143.00

The protein kinase A activator Sp-cAMPS (Cat. No. A 003) immobilized on agarose by an aminoethylcarbamoyl spacer attached to the ribose 2' position of the ligand. Free Sp-cAMPS is only very slowly metabolized by mammalian phosphodiesterases and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase A compared to cAMP results in milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins, especially those which tolerate modification of the 2'-ribose hydroxyl group such as some phosphodiesterases. This type of gel is offered with a longer spacer (Sp-2'-AHC-cAMPS-Agarose, Cat. No. A 050) as well. Detailed technical information available. Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.

Cat. No. A 122
CAS number [pending]
Storage temperature 4°C / 39°F
cAMP modified at the exocyclic oxygen axial (Sp-)
Modifications 2'-cAMP
Lipophilicity 1.09