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Rp-UTP-α-S

Uridine- 5'- O- (1-thiotriphosphate), Rp- isomer ( Rp-UTP-α-S ), sodium salt
Cat. No.: U 002
    
CAS No.: [71214-30-7]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: U 002-05
Unit: 5 µmol / ~2.5 mg
$253.00

For other salt forms or a guaranteed higher purity please inquire.
Useful for modulation of UTP-responsive receptors and determination of their stereospecificity. Increased metabolic stability compared to UTP. Not accepted by RNA polymerases. Detailed technical information available. Reference: Sheu et al., Biochemistry, 18, 5548 - 5556 (1979).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. U 002
CAS number [71214-30-7]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₉H₁₅N₂O₁₄P₃S (free acid)
Molecular weight [g/mol] 500,2 (free acid)
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 10000
  • 1. Jacobson K. A., Costanzi S., Ivanov A. A., Tchilibon S., Besada P., Gao Z.-G., Maddileti S.Harden T. K., Biochem. Pharmacol., 71, 540 - 549 (2006), "Structure Activity and Molecular Modeling Analyses of Ribose- and Base-modified Uridine 5'-triphosphate Analogues at the Human P2Y2 and P2Y4 Receptors"
  • 2. Ryder S. P.Strobel S. A., Methods Enzymol., 18, 38 - 50 (1999), "Nucleotide Analog Interference Mapping"
  • 3. Arabshani A.Frey P. A., Biochem. Biophys. Res. Commun., 204, 150 - 155 (1994), "A Simplified Procedure for Synthesizing Nucleoside 1-Thiotriphosphates: dATP-alpha-S, dGTP-alpha-S, UTP-alpha-S and dTTP-alpha-S"
  • 4. Frey P. A., Tetrahedron, 38, 1541 - 1567 (1982), "Stereochemistry of Enzymatic Reactions of Phosphates"
  • 5. Eckstein F., Accounts of Chemical Research, 12, 204 - 210 (1979), "Phosphorothioate analogues of nucleotides"
  • 6. Sheu K.-F. R., Richard J. P.Frey P. A., Biochemistry, 18, 5548 - 5556 (1979), "Stereochemical Courses of Nucleotidyltransferase and Phosphotransferase Action. Uridine Diphosphate Glucose Pyrophosphorylase, Galactose-1-phosphate Uridylyltransferase, Adenylate Kinase, and Nucleoside Diphosphate Kinase"
  • 7. Sheu K.-F. R.Frey P. A., J. Biol. Chem., 253, 3378 - 3380 (1978), "UDP-glucose Pyrophosphorylase"
  • 8. Midelfort C. F.Sarton-Miller I., J. Biol. Chem., 253, 7127 - 7129 (1978), "The Stereochemical Course of Acetate Activation by Yeast Acetyl-CoA Synthetase"