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Rp,Rp-c-diGMPSS

Cyclic diguanosine monophosphorodithioate, Rp- isomers ( Rp,Rp-c-diGMPSS ), sodium salt
Di-thiophosphate analogue of c-diGMP
Cat. No.: C 129
    
CAS No.: [1259875-41-6]
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Product Name Price (net) Qty
Cat. No.: C 129-001
Unit: 0.1 µmol / ~72 µg
$286.00

For other salt forms please inquire. Sulfur-modified analogue of the bacterial second messenger c-diGMP (Cat. No. C 057) with increased metabolic stability. Rp,Rp-c-diGMPSS can be useful in studies on ligand-receptor interactions. Detailed technical information available. References: Yan et al., Bioorg. Med. Chem. Lett., 18, 5631 - 5634 (2008); Shanahan et al., J. Am. Chem. Soc., 133, 15578 - 15592 (2011); Shanahan et al., Biochemistry, 52, 365 - 377 (2013).

Cat. No. C 129
CAS number [1259875-41-6]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₂P₂S₂ (free acid)
Molecular weight [g/mol] 722,6 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 26100
  • 1. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., Biochemistry, 52, 365 - 377 (2013), "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase"
  • 2. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., J. Am. Chem. Soc., 133, 15578 - 15592 (2011), "Differential Analogue Binding by Two Classes of C-Di-GMP Riboswitches"
  • 3. Yan H., Wang X., KuoLee R.Chen W., Bioorg. Med. Chem. Lett., 18, 5631 - 5634 (2008), "Synthesis and Immunostimulatory Properties of the Phosphorothioate Analogues of c-di-GMP"