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Rp-dCTP-α-S

2'- Deoxycytidine- 5'- O- (1- thiotriphosphate), Rp- isomer ( Rp-dCTP-α-S ), sodium salt
Cat. No.: D 046
    
CAS No.: [80951-76-4]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: D 046-05
Unit: 5 µmol / ~2.4 mg
$299.00

For other salt forms or a guaranteed higher purity please inquire. Useful for modulation of dCTP-responsive receptors and determination of their stereospecificity. Increased metabolic stability compared to dCTP. Not accepted by DNA polymerases. Detailed technical information available. Reference: Abbotts et al., J. Biol. Chem., 263, 15094 - 15103 (1988).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. D 046
CAS number [80951-76-4]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₉H₁₆N₃O₁₂P₃S (free acid)
Molecular weight [g/mol] 483,2 (free acid)
Absorption max [nm] 271
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 9000
  • 1. Ryder S. P.Strobel S. A., Methods Enzymol., 18, 38 - 50 (1999), "Nucleotide Analog Interference Mapping"
  • 2. Abbotts J., SenGupta D. N., Zon G.Wilson S. H., J. Biol. Chem., 263, 15094 - 15103 (1988), "Studies on the Mechanism of Escherichia coli DNA Polymerase I Large Fragment"
  • 3. Goody R. S.Isakov M., Tetrahedron Lett., 27, 3599 - 3602 (1986), "Simple Synthesis and Separation of the Diastereomers of alpha-Thio Analogs of Ribo- and Deoxyribo-di- and Triphosphates"
  • 4. Goody R., Isakov M.Labeit S., Ger. Offen. DE 3374, 546, 0 - 0 (1985), "DNA Sequencing Involving Alpha-thiodeoxyribonucleotide triphosphate-labeled DNA and Exonuclease Digestion, Synthesis of Alpha-thionucleotide triphosphates and Resolution of the Resulting Diastereomeric Mixture"