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Alternative structural projections:

Rp-8-pCPT-PET-cGMPS

8- (4- Chlorophenylthio)- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-pCPT-PET-cGMPS ), sodium salt
Potent, PDE-resistant inhibitor of protein kinase G
Cat. No.: C 046
    
CAS No.: [1262749-62-1]
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Product Name Price (net) Qty
Cat. No.: C 046-01
Unit: 1 µmol / ~0.6 mg
$165.00
Potent inhibitor of protein kinase G. Most probably retinal cGMP-gated ion channels are inhibited as well. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane-permeant compared to all other cGK inhibitors offered. Detailed technical information available. References: Broderick et al., Mol. Endocrinol., 21, 1148 - 1162 (2007); Zhang et al., J. Biol. Chem., 282, 3367 - 33380 (2007).
Cat. No. C 046
Patent Information Protected under patents US 5,625,056, DE 42 17679 issued to BIOLOG LSI
CAS number [1262749-62-1]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₂₄H₁₈ClN₅O₆PS₂ · Na
Molecular weight [g/mol] 626,0
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Inhibitor
Lipophilicity 3.53
Absorption max [nm] 276
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40000
  • 1. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 2. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 3. Broderick K. E., Zhang T., Rangaswami H., Zeng Y., Zhao X., Boss G. R.Pilz R. B., Mol. Endocrinol., 21, 1148 - 1162 (2007), "Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent Protein Kinase Induce Interleukin-6 Transcription in Osteoblasts"
  • 4. Zhang T., Zhuang S., Casteel D. E., Looney D. J., Boss G. R.Pilz R. B., J. Biol. Chem., 282, 33367 - 33380 (2007), "A Cysteine-rich LIM-only Protein Mediates Regulation of Smooth Muscle-specific Gene Expression by cGMP-dependent Protein Kinase"