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Rp-8-pCPT-cGMPS

8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer (Rp-8-pCPT-cGMPS ), sodium salt
Membrane-permeant and PDE-resistant PKG inhibitor
Cat. No.: C 013
    
CAS No.: [153660-04-9]
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Product Name Price (net) Qty
Cat. No.: C 013-01
Unit: 1 µmol / ~0.5 mg
$121.00
Specially purified quality, fluorescent impurities removed. For other salt forms please inquire. Potent selective inhibitor of protein kinase G I a, I ß and especially of type II. Activates retinal cGMP channels and thus discriminates between kinase and channel effects. Absolutely resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane-permeant compared to Rp-cGMPS or Rp-8-Br-cGMPS. Detailed technical information and updated reference list available on request. References: Butt et al., Eur. J. Pharmacol., 269, 265 - 268 (1994); Gamm et al., J. Biol. Chem., 270, 27380 - 27388 (1996); Kramer et al., J. Neurosci., 16, 1285 - 1293 (1996).
Cat. No. C 013
Patent Information Protected under patents US 5,625,056, DE 42 17679 issued to BIOLOG LSI
CAS number [153660-04-9]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₆H₁₄ClN₅O₆PS₂ · Na
Molecular weight [g/mol] 525,9
Modifications 8-cGMP
Target PKG (cGK) Inhibitor
Lipophilicity 2.61
Absorption max [nm] 276
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 21500
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