0 Items - $0.00
Categories
A to Z

Alternative structural projections:

Rp-8-Br-cGMPS

8- Bromoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-cGMPS ), sodium salt
PDE-resistant inhibitor of protein kinase G I α and I ß
Cat. No.: B 005
    
CAS No.: [150418-07-8]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: B 005-05
Unit: 5 µmol / ~2.3 mg
$420.00

For other salt forms please inquire. Inhibitor of protein kinase G I α and I β. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane-permeant compared to cyclic GMP or Rp-cGMPS. Detailed technical information and updated reference list available on request. Reference: Zhuo et al., Nature 368, 635 - 639 (1994).

Cat. No. B 005
CAS number [150418-07-8]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₀BrN₅O₆PS · Na
Molecular weight [g/mol] 462.2
Modifications 8-cGMP
Target PKG (cGK) Inhibitor
Lipophilicity 1.29
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16200
  • 1. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 2. Paquet-Durand F., Hauck S., Van Veen T., Ueffing M.Ekström P., J. Neurochem., 108, 796 - 810 (2009), "PKG Activity Causes Photoreceptor Cell Death in Two Retinitis pigmentosa Models"
  • 3. Garcha R. S.Hughes A. D., J. Renin-Angiotensin-Aldosterone Syst., 7, 87 - 91 (2006), "CNP, but not ANP or BNP, Relax Human Isolated Subcutaneous Resistance Arteries by an Action Involving cyclic GMP and BKCa Channels"
  • 4. Mewe M., Bauer C. K., Müller D.Middendorff R., Endocrinology, 147, 2051 - 2062 (2006), "Regulation of Spontaneous Contractile Activity in the Bovine Epididymal Duct by Cyclic Guanosine 5'- monophosphate-dependent Pathways"
  • 5. Brown R. L., Strassmaier T., Brady J. D.Karpen J. W., Curr. Pharmaceut. Design, 12, 3597 - 3613 (2006), "The Pharmacology of Cyclic Nucleotide-Gated Channels: Emerging from the Darkness"
  • 6. Keung W., Vanhoutte P. M.Man R. Y. K., Brit. J. Pharmacol., 144, 71 - 79 (2005), "Acute Impairment of Contractile Responses by 17-Beta-estradiol is cAMP and Protein Kinase G Dependent in Vascular Smooth Muscle Cells of the Porcine Coronary Arteries"
  • 7. Zhuang D., Ceacareanu A. C., Ceacareanu B.Hassid A., Amer. J. Physiol.-Heart Circ. Phy., 288, 1859 - 1866 (2005), "Essential Role of Protein Kinase G and Decreased Cytoplasmic Ca2+ Levels in NO-induced Inhibition of Rat Aortic Smooth Muscle Cell Motility"
  • 8. Muzaffar S., Shukla N., Srivastava A., Angelini G. D.Jeremy J. Y., Brit. J. Pharmacol., 146, 109 - 117 (2005), "Sildenafil Citrate and Sildenafil Nitrate (NCX 911) are Potent Inhibitors of Superoxide Formation and gp91phox Expression in Porcine Pulmonary Artery Endothelial Cells"
  • 9. Lohmann S. M.Walter U., Frontiers Biosci., 10, 1313 - 1328 (2005), "Tracking Functions of cGMP-dependent Protein Kinase"
  • 10. Tegeder I., Del Turco D., Schmidtko A., Sausbier M., Feil R., Hofmann F., Deller T., Ruth P.Geisslinger G., Proc. Natl. Acad. Sci. U.S.A., 101, 3253 - 3257 (2004), "Reduced Inflammatory Hyperalgesia with Preservation of Acute Thermal Nociception in Mice Lacking cGMP-dependent Protein Kinase I"
  • 11. Oldenburg O., Qin Q. N., Krieg T., Yang X. M., Philipp S., Critz S. D., Cohen M. V.Downcy J. M., Am. J. Physiol.-Heart Circul. Physiol., 286, 468 - 476 (2004), "Bradykinin Induces Mitrochondrial ROS Generation via NO, cGMP, PKG, and MitoK(ATP) Channel Opening and Leads to Cardioprotection"
  • 12. Chan S. H. H., Chang K. F., Ou C. C.Chan J. Y. H., Mol. Pharmacol., 65, 319 - 325 (2004), "Nitric Oxide Regulates c-fos Expression in Nucleus Tractus Solitarii Induced by Baroreceptor Activation via cGMP-dependent Protein Kinase and cAMP Response Element-binding Phosphorylation"
  • 13. Jin X. H., McGrath H. E., Gildea J. J., Siragy H. M., Felder R. A.Carey R. M., Hypertension., 43, 1133 - 1139 (2004), "Renal Interstitial Guanosine Cyclic 3', 5'-monophosphate Mediates Pressure-natriuresis via Protein Kinase G"
  • 14. Chalupsky K., Lobysheva I., Nepveu F., Gadea I., Beranova P., Entlicher G., Stoclet J.-C.Müller B., Biochem. Pharmacol., 67, 1203 - 1214 (2004), "Relaxant Effect of Oxime Derivatives in Isolated Rat Aorta: Role of Nitric Oxide (NO) Formation in Smooth Muscle"
  • 15. Barnstable C. J., Wei J. Y.Han M. H., Neurochem. Int., 45, 875 - 884 (2004), "Modulation of Synaptic Function by cGMP and cGMP-gated Cation Channels"
  • 16. Gragasin F. S., Michelakis E. D., Hogan A., Moudgil R., Hashimoto K., Wu X. C., Bonnent S., Haromy A.Archer S. L., FASEB Journal, 18, 1382 - 391 (2004), "The Neurovascular Mechanism of Clitoral Erection: Nitric Oxide and cGMP-stimulated Activation of BKCa Channels"
  • 17. Carvajal J. A., Thompson L. P.Weiner C. P., Am. J. Obstet. Gynecol., 188, 84 - 91 (2003), "Chorion-induced Myometrial Relaxation is Mediated by Large-Conductance Ca2+-Activated K+ Channel Opening in the Guinea Pig"
  • 18. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 19. Deng W., Parbhu-Patel A., Meyer D. J.Baker D. A., Biochem. J., 374, 559 - 565 (2003), "The Role of Two Novel Regulatory Sites in the Activation of the cGMP-dependent Protein Kinase from Plasmodium Falciparum"
  • 20. Alencar J. L., Lobysheva I., Geffard M., Sarr M., Schott C., Schini-Kerth V. B., Nepveu F., Stoclet J.-C.Muller B., Mol. Pharmacol., 63, 1148 - 1158 (2003), "Role of S-nitrosation of Cysteine Residues in Long-lasting Inhibitory Effect of Nitric Oxide on Arterial Tone"
  • 21. Schmidtko A., Ruth P., Geisslinger G.Tegeder I., Nitric Oxide-Biol. Chem., 8, 89 - 94 (2003), "Inhibition of Cyclic Guanosine 5'-Monophosphate-dependent Protein Kinase 1 (PKG-1) in Lumbar Spinal Cord Reduces Formalin-induced Hyperalgesia and PKG Upregulation"
  • 22. Huang C. C., Chan S. H. H.Hsu K. S., Mol. Pharmacol., 64, 521 - 532 (2003), "cGMP/Protein Kinase G-dependent Potentation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro"
  • 23. Layland J., Li J. M.Shah A. M., J. Physiol.-London, 540, 457 - 467 (2002), "Role of Cyclic GMP-dependent Protein Kinase in the Contractile Response to Exogenous Nitric Oxide in Rat Cardiac Myocytes"
  • 24. Andersson J. A., Uddman R.Cardell L.-O., Allergy, 57, 1008 - 1012 (2002), "Hemin, a Heme Oxygenase Substrate Analog, Both Inhibits and Enhances Neutrophil Random Migration and Chemotaxis"
  • 25. Cook A. L. M., Frydenberg M.Haynes J. M., Cell. Signal., 14, 1023 - 1029 (2002), "Protein Kinase G Activation of K-ATP Channels in Human-cultured Prostatic Stromal Cells"
  • 26. Diebolt M.Andriantsitohaina R., Fundam. Clin. Pharmacol., 16, 289 - 296 (2002), "Wine Polyphenols Modulate Calcium Handling in Rat Aorta: Involvement of Nitric Oxide Pathway"
  • 27. Tegeder I., Schmidtko A., Niederberger E., Ruth P.Geisslinger G., Neurosci. Lett. 146 - 150 & Abstract of the 13th Protein Kinase Symposium Oslo/Norway September 12th - 15th p. 31, 332, 146 - 150 (2002), "Dual Effects of Spinally Delivered 8-Bromo-cyclic Guanosine Monophosphate (8-Bromo-cGMP) in Formalin-induced Nociception in Rats"
  • 28. Song R. P., Mahidhara R. S., Liu F., Ning W., Otterbein L. E.Choi A. M. K., Am. J. Respir. Cell Mol. Biol., 27, 603 - 610 (2002), "Carbon Monoxide Inhibits Human Airway Smooth Muscle Cell Proliferation via Mitogen-activated Protein Kinase Pathway"
  • 29. Monfort P., Munoz M. D., Kosenko E.Felipo V., J. Neurosci., 22, 10116 - 10122 (2002), "Long-Term Potentiation in Hippocampus Involves Sequential Activation of Soluble Guanylate Cyclase, cGMP-dependent Protein Kinase, and cGMP-degrading Phosphodiesterase"
  • 30. Deng W.Baker D. A., Mol. Microbiol., 44, 1141 - 1151 (2002), "A Novel Cyclic GMP-dependent Protein Kinase is Expressed in the Ring Stage of the Plasmodium Falciparum Life Cycle"
  • 31. Sellak H., Yang X., Cao X., Cornwell T., Soff G. A.Lincoln T., Circ. Res., 90, 405 - 412 (2002), "Sp1 Trancription Factor as a Molecular Target for Nitric Oxide- and Cyclic Nucleotide-Mediated Suppression of cGMP-dependent Protein Kinase-1@ Expression in Vascular Smooth Muscle Cells"
  • 32. Centonze D., Pisani A., Bonsi P., Giacomini P., Bernardi G.Calabresi P., J. Neurosci., 21, 1393 - 1400 (2001), "Stimulation of Nitric Oxide-cGMP Pathway Excites Striatal Cholinergic Interneurons via Protein Kinase G Activation"
  • 33. Revelli A., Costamagna C., Moffa F., Aldieri E., Ochetti S., Bosia A., Massobrio M., Lindblom B.Ghigo D., Biol. Reprod., 64, 1708 - 1712 (2001), "Signaling Pathway of Nitric Oxide-induced Acrosome Reaction in Human Spermatozoa"
  • 34. Carvajal J. A., Aguan K., Thompson L. P., Buhimschi I. A.Weiner C. P., J. Pharmacol. Exp. Ther., 297, 181 - 188 (2001), "Natriuretic Peptide-induced Relaxation of Myometrium from the Pregnant Guinea Pig is not Mediated by Guanylate Cyclase Activation"
  • 35. Kinhult J., Uddman R.Cardell L.-O., Lung, 179, 1 - 8 (2001), "The Induction of Carbon Monoxide-mediated Airway Relaxation by PACAP 38 in Isolated Guinea Pig Airways"
  • 36. Collins J. L., Vodovotz Y., Yoneyama T., Hatakeyama K., Green A. M.Billiar T. R., Surgery, 130, 256 - 264 (2001), "Catecholamines Decrease Nitric Oxide Production by Cytokine-Stimulated Hepatocytes"
  • 37. Takeuchi T., Sugimoto K., Morimoto H., Fujita A.Hata F., Jpn. J. Pharmacol., 86, 390 - 398 (2001), "Mechanism of a Nitric Oxide Donor NOR 1-induced Relaxation in Longitudinal Muscle of Rat Proximal Colon"
  • 38. Saparov S. M., Kozono D., Rothe U., Agre P.Pohl P., J. Biol. Chem., 276, 31515 - 31520 (2001), "Water and Ion Permeation of Aquaporin-1 in Planar Lipid Bilayers"
  • 39. Gertzberg N., Clements R., Jaspers I., Ferro T. J., Neumann P., Flescher E.Johnson A., Am. J. Respir. Cell. Mol. Biol., 22, 105 - 115 (2000), "Tumor Necrosis Factor-Alpha Induced Activating Protein-1 Activity is modulated by Nitric Oxide-Mediated Protein Kinase G Activation"
  • 40. Teoh H.Man R. Y. K., Br. J. Pharmacol., 129, 1739 - 1747 (2000), "Enhanced Relaxation of Porcine Coronary Arteries after Acute Exposure to a Physiological Level of 17 Beta-Estradiol Involves Non-Genomic Mechanisms and the Cyclic AMP Cascade"
  • 41. Sirotkin A. V., Makarevich A. V., Genieser H.-G., Kotwica J.Hetenyi L., Exp. Clin. Endocrinol. Diabetes, 108, 214 - 219 (2000), "Effect of four cGMP Analogues with Different Mechanisms of Action on Hormone Release by Porcine Ovarian Granulosa Cells In Vitro"
  • 42. Pham N., Cheglakov I., Koch C. A., de Hoog C. L., Moran M. F.Rotin D., Curr. Biol., 10, 555 - 558 (2000), "The Guanine Nucleotide Exchange Factor CNrasGEF Activates Ras in Response to cAMP and cGMP"
  • 43. Kalra D., Baumgarten G., Dibbs Z., Seta Y., Sivasubramanian N.Mann D. L., Circulation, 102, 1302 - 1307 (2000), "Nitric Oxide Provokes Tumor Necrosis Factor-Alpha Expression in Adult Feline Myocardium through a cGMP-Dependent Pathway"
  • 44. Schwede F., Maronde E., Genieser H.-G.Jastorff B., Pharmacol. Ther., 87, 199 - 226 (2000), "Cyclic Nucleotide Analogs as Biochemical Tools and Prospective Drugs"
  • 45. Homer K. L.Wanstall J. C., Br. J. Pharmacol., 131, 673 - 682 (2000), "Cyclic GMP-independent Relaxation of Rat Pulmonary Artery by Spermine NONOate, a Diazeniumdiolate Nitric Oxide Donor"
  • 46. Sirotkin A. V., Makarevich A. V., Pivko J., Kotwica J., Genieser H.-G.Bulla J., J. Steroid Biochem. Mol. Biol., 74, 1 - 9 (2000), "Effect of cGMP Analogues and Protein Kinase G Blocker on Secretory Activity, Apoptosis and the cAMP/Protein Kinase A System in Porcine Ovarian Granulosa Cells In Vitro"
  • 47. van der Zypp A., Rechtman M.Majewski H., Gen. Pharmacol. - The Vasc. Syst., 34, 245 - 253 (2000), "The Role of Cyclic Nucleotides and Calcium in the Relaxation Produced by Amrinone in Rat Aorta"
  • 48. Lei S., Jackson M. F., Jia Z., Roder J., Bai D., Orser B. A.MacDonald J. F., Nature Neurosci., 3, 559 - 565 (2000), "Cyclic GMP-dependent Feedback Inhibition of AMPA Receptors is Independent of PKG"
  • 49. De la Lande I. S., Stafford I.Horowitz J. D., Eur. J. Pharmacol., 370, 39 - 46 (1999), "Effects of Guanylyl Cyclase and Protein Kinase G Inhibitors on Vasodilatation in Non-tolerant and Tolerant Bovine Coronary Arteries"
  • 50. Armstead W. M., Brain Res., 835, 315 - 323 (1999), "Nociceptin/Orphanin FQ Dilates Pial Arteries by K-ATP and K-Ca Channel Activation"
  • 51. Fan Y.-P., Chakder S.Rattan S., Am. J. Physiol.-Gastroint. Liver Physiol., 40, 152 - 160 (1999), "Mechanisms of Action of Cholera Toxin on the Opossum Internal Anal Sphincter Smooth Muscle"
  • 52. Shiraha H., Glading A., Gupta K.Wells A., J. Cell Biol., 146, 243 - 253 (1999), "IP-10 Inhibits Epidermal Growth Factor-Induced Motility by Decreasing Epidermal Growth Factor Receptor-Mediated Calpain Activity"
  • 53. Ishida A., Sasaguri T., Miwa Y., Kosaka C., Taba Y.Abumiya T., Mol. Pharmacol., 56, 938 - 946 (1999), "Tumor Suppressor p53 but not cGMP Mediates NO-Induced Expression of p21 (Waf1/Cip1/Sdi1) in Vascular Smooth Muscle Cells"
  • 54. Pfeifer A., Ruth P., Dostmann W., Sausbier M., Klatt P.Hofmann F., in Rev. Physiol. Biochem. Pharmacol. Berlin / Springer, 135, 105 - 149 (1999), "Structure and Function of cGMP-Dependent Protein Kinases"
  • 55. Dong S. S., Williams J. P., Jordan S. E., Cornwell T.Blair H. C., J. Cell. Biochem., 73, 478 - 487 (1999), "Nitric Oxide Regulation of cGMP Production in Osteoclasts"
  • 56. Sirotkin A., Makarevic A., Kotwica J., Genieser H.-G.Bulla J., J. Farm. Animal. Sci., 32, 11 - 14 (1999), "Effect of Chemical Analogues of cAMP and cGMP on Hormone and Growth Factor Secretion by Porcine Ovarian Cells"
  • 57. Wei J.-Y., Cohen E. D., Genieser H.-G.Barnstable C. J., J. Mol. Neurosci., 10, 53 - 64 (1998), "Substituted cGMP Analogs Can Act as Selective Agonists of the Rod Photoreceptor cGMP-Gated Cation Channel"
  • 58. Nakazawa M., Watanabe Y., Toyosato A., Yoshida Y.Higuchi H., Naunyn-Schmied. Arch. Pharmacol. XIIIth. Int. Congr. Pharmacol. Munich R 662 P 22.14, 358, 2 - 0 (1998), "Effects of Calcium Concentration on Rp-8-Br-cGMPS-induced Inhibition of Relaxation by Nitroprusside in the Rat Aorta"
  • 59. van der Zypp A.Majewski H., Clin. Exp. Pharmacol. Physiol., 25, 38 - 43 (1998), "Effect of cGMP Inhibitors on the Actions of Nitrodilators in Rat Aorta"
  • 60. Cousson A.Vavasseur A., Planta, 206, 308 - 314 (1998), "Putative Involvement of Cytosolic Ca2+ and GTP-Binding Proteins in Cyclic-GMP-mediated Induction of Stomatal Opening by Auxin in Commelina Communis L"
  • 61. Ruiz-Velasco V., Zhong J., Hume J. R.Keef K. D., Circ. Res., 82, 557 - 565 (1998), "Modulation of Ca2+ Channels by Cyclic Nucleotide Cross Activation of Opposing Protein Kinases in Rabbit Portal Vein"
  • 62. Weisbrod R. M., Griswold M. C., Yaghoubi M., Komalavilas P., Lincoln T. M.Cohen R. A., Brit. J. Pharmacol., 125, 1695 - 1707 (1998), "Evidence that Additional Mechanisms to Cyclic GMP Mediate the Decrease in Intracellular Calcium and Relaxation of Rabbit Aortic Smooth Muscle to Nitric Oxide"
  • 63. Muller B., Kleschyov A. L., Malblanc S.Stoclet J.-C., Brit. J. Pharmacol., 123, 1221 - 1229 (1998), "Nitric Oxide-Related Cyclic GMP-Independent Relaxing Effect of N-Acetylcysteine in Lipopolysaccharide-Treated Rat Aorta"
  • 64. Armstead W. M., Brain Res., 799, 44 - 48 (1998), "Contribution of K-CA Channel Activation to Hypoxic Cerebrovasodilation does not Involve NO"
  • 65. Wei J.-Y., Roy D. S., Leconte L.Barnstable C. J., Prog. Neurobiol., 56, 37 - 64 (1998), "Molecular and Pharmacological Analysis of Cyclic Nucleotide-Gated Channel Function in the Central Nervous System"
  • 66. Beaumont V., Hepworth M. B., Luty J. S., Kelly E.Henderson G., J. Biol. Chem., 273, 33174 - 33183 (1998), "Somatostatin Receptor Desensitization in NG108-15 Cells"
  • 67. Elferink J. G. R.de Koster B. M., Immunopharmacology, 38, 229 - 236 (1998), "N-Acetylcysteine Causes a Transient Stimulation of Neutrophil Migration"
  • 68. Forloni G., Lucca E., Angeretti N., Chiesa R.Vezzani A., J. Neurochem., 68, 319 - 327 (1997), "Neuroprotective Effect of Somatostatin on Nonapoptotic NMDA-Induced Neuronal Death - Role of Cyclic GMP"
  • 69. Armstead W. M., J. Cerebr. Blood Flow Metabol., 17, 100 - 108 (1997), "Role of Nitric Oxide, Cyclic Nucleotides, and the Activation of ATP-Sensitive K+ Channels in the Contribution of Adenosine to Hypoxia-Induced Pial Artery Dilation"
  • 70. Kawada T., Toyosato A., Islam M. O., Yoshida Y.Imai S., Eur. J. Pharmacol., 323, 75 - 82 (1997), "cGMP-Kinase Mediates cGMP- and cAMP-Induced CA2+ Desensitization of Skinned Rat Artery"
  • 71. Rossberg M. L.Armstead W. M., Pediat. Res., 41, 498 - 504 (1997), "Role of Cyclic Nucleotides in Vasopressin-Induced Piglet Pial Artery Dilation and Opioid Release"
  • 72. Elferink J. G. R., Daha M. R.de Koster B. M., Cell. Mol. Life Sci., 53, 593 - 599 (1997), "A Cyclic GMP- and G-kinase-dependent Effect of Azathioprine on Migration by Human Neutrophils"
  • 73. Eckly-Michel A., Martin V.Lugnier C., Brit. J. Pharmacol., 122, 158 - 164 (1997), "Involvement of Cyclic Nucleotide-Dependent Protein Kinases in Cyclic AMP-Mediated Vasorelaxation"
  • 74. Yamamoto K., Ikeda U.Shimada K., J. Mol. Cell Cardiol., 29, 2375 - 2382 (1997), "Natriuretic Peptides Modulate Nitric Oxide Synthesis in Cytokine-stimulated Cardiac Myocytes"
  • 75. Wei J.-Y., Cohen E. D.Barnstable C. J., Neurosci. Lett., 233, 37 - 40 (1997), "Direct Blockade of Both Cloned Rat Rod Photoreceptor Cyclic nucleotide-gated Non-selective Cation (CNG) Channel @-subunit and Native CNG Channels from Xenopus Rod Outer Segments by H-8, a Non-specific Cyclic Nucleotide-dependent Protein Kinase Inhibitor"
  • 76. Wegener J. W., Gath I., Förstermann U.Nawrath H., Br. J. Pharmacol., 122, 1523 - 1529 (1997), "Activation of Soluble Guanylyl Cyclase by YC-1 in Aortic Smooth Muscle but not in Ventricular Myocardium from Rat"
  • 77. Van Uffelen B. E., van Steveninck J.Elferink J. G. R., Immunopharmacology, 37, 257 - 267 (1997), "Potentiation and Inhibition of FMLP-Activated Exocytosis in Neutrophils by Exogenous Nitric Oxide"
  • 78. Clancy R. M., Rediske J., Tang X. Y., Nijher N., Frenkel S., Philips M.Abramson S. B., J. Clin. Invest., 100, 1789 - 1796 (1997), "Outside-In Signalling in the Chondrocyte - Nitric Oxide Disrupts Fibronectin-Induced Assembly of a Subplasmalemmal Actin RHO a Focal Adhesion Kinase Signalling Complex"
  • 79. Elferink J. G. R., Daha M. R.de Koster B. M., Inflammation, 21, 93 - 103 (1997), "The Effect of Sodium Aurothiomalate on Stimulated and Non-Stimulated Migration by Human Neutrophils: The Role of Cyclic GMP"
  • 80. Aaronson P. I., McKinnon W.Poston L., Brit. J. Pharmacol., 117, 365 - 371 (1996), "Mechanism of Butyrate-induced Vasorelaxation of Rat Mesenteric Resistance Artery"
  • 81. Nakamura A., Fujita M.Shiomi H., Brit. J. Pharmacol., 117, 407 - 412 (1996), "Involvement of Endogenous Nitric Oxide in the Mechanism of Bradykinin-induced Peripheral Hyperalgesia"
  • 82. Peng W., Hoidal J. R.Farrukh I. S., J. Appl. Physiol., 81, 1264 - 1272 (1996), "Regulation of Ca2+-Activated K+Channels in Pulmonary Vascular Smooth Muscle Cells: Role of Nitric Oxide"
  • 83. Armstead W. M., Am. J. Physiol., 40, 166 - 172 (1996), "cGMP and cAMP in Prostaglandin-induced Pial Artery Dilation and Increased CSF Opioid Concentration"
  • 84. Van Uffelen B. E., de Koster B. M., van den Broek P. J. A., van Steveninck J.Elferink J. G. R., J. Leucocyte Biol., 60, 94 - 100 (1996), "Modulation of Neutrophil Migration by Exogenous Gaseous Nitric Oxide"
  • 85. Barger S. W.Mattson M. P., Mol. Brain Res., 40, 116 - 126 (1996), "Induction of Neuroprotective kB-dependent Transcription by Secreted Forms of the Alzheimer's Beta-Amyloid Precursor"
  • 86. Wilderman M. J.Armstead W. M., Am. J. Physiol., 39, 869 - 874 (1996), "Relationship Between Nitric Oxide and Opioids in Hypoxia-induced Pial Artery Vasodilation"
  • 87. Takeuchi T., Kishi M., Ishii T., Nishio H.Hata F., Br. J. Pharmacol., 117, 1204 - 1208 (1996), "Nitric oxide-mediated Relaxation Without Concomitant Changes in cyclic GMP Content of Rat Proximal Colon"
  • 88. Rooney T. A., Joseph S. K., Queen C.Thomas A. P., J. Biol. Chem., 271, 19817 - 19825 (1996), "Cyclic GMP Induces Oscillatory Calcium Signals in Rat Hepatocytes"
  • 89. Toyosato A., Yoshida Y., Islam M. O.Imai S., Jpn. J. Pharmacol., 71, 143 - 0 (1996), "Effects of Rp-8-Bromo-guanosine 3', 5'- Cyclic Monophosphorothioate (Rp-8-Br-cGMPS) on cGMP-dependent Protein Kinase (cGMP Kinase) Type I-alpha and I-beta"
  • 90. Andriantsitohaina R., Okruhlicova L., De Franca Cortes S., Lagaud G. J. L., Randriamboavonjy V., Muller B.Stoclet J.-C., J. Vasc. Res., 33, 386 - 394 (1996), "Role of Endothelial Nitric Oxide in the Response to Angiotensin II of Small Mesenteric Arteries of the Rat"
  • 91. Nakamura A.Shiomi H., Fol. Pharmacol. Jap., 108, 143 - 148 (1996), "Signal Transduction System Involved in the Mechanism of Peripheral Mechanical Hyperalgesia"
  • 92. Murphy-Ullrich J. E., Pallero M. A., Boerth N., Greenwood J. A., Lincoln T. M.Cornwell T. L., J. Cell Sci., 109, 2499 - 2508 (1996), "Cyclic GMP-dependent Protein Kinase is Required for Thrombospondin and Tenascin Mediated Focal Adhesion Disassembly"
  • 93. Bito H., Deisseroth K.Tsien R. W., Cell, 87, 1203 - 1214 (1996), "CREB Phosphorylation and Dephosphorylation: A Ca²+- and Stimulus Duration-Dependent Switch for Hippocampal Gene Expression"
  • 94. Yu S.-M., Cheng Z.-J.Kuo S.-C., Br. J. Pharmacol., 114, 1227 - 1235 (1995), "Antiproliferative Effects of A02011-1, an Adenylate Cyclase Activator, in Cultured Vascular Smooth Muscle Cells of Rat"
  • 95. Schini-Kerth V. B., Fisslthaler B.Busse R., Am. J. Physiol., 36, 2483 - 2490 (1995), "CGRP Enhances Induction of NO Synthase in Vascular Smooth Muscle Cells Via a cAMP-dependent Mechanism"
  • 96. Bäumner D.Nawrath H., Eur. J. Pharmacol., 273, 295 - 298 (1995), "Effects of Inhibitors of cGMP-dependent Protein Kinase in Atrial Heart and Aortic Smooth Muscle From Rats"
  • 97. Andriantsitohaina R., Lagaud G. J.-L., Andre A., Muller B.Stoclet J.-C., Am. J. Physiol., 37, 1223 - 1231 (1995), "Effects of cGMP on Calcium Handling in ATP-stimulated Rat Resistance Arteries"
  • 98. Barger S. W., Fiscus R. R., Ruth P., Hofmann F.Mattson M. P., J. Neurochem., 64, 2087 - 2096 (1995), "Role of Cyclic GMP in the Regulation of Neuronal Calcium and Survival by Secreted Forms of Beta-Amyloid Precursor"
  • 99. Blitzer R. D., Wong T., Nouranifar R., Iyengar R.Landau E. M., Neuron, 15, 1403 - 1414 (1995), "Postsynaptic cAMP Pathway Gates Early LTP in Hippocampal CA1 Region"
  • 100. Genieser H.-G., Proc. 9. Int. Conf. Second Mess. & Phosphoprot. TN USA, 0, 0 - 0 (1995), "Lipophilic Ranking of Biologically Important Cyclic Nucleotides"
  • 101. Cabrera C.Bohr D., Biochem. Biophys. Res. Commun., 206, 77 - 81 (1995), "The Role of Nitric Oxide in the Central Control of Blood Pressure"
  • 102. Clementi E., Sciorati C.Nistico G., Mol. Pharm., 48, 1068 - 1077 (1995), "Growth Factor-Induced Ca2+ Responses are Differentially Modulated by Nitric Oxide via Activation of a Cyclic GMP-dependent Pathway"
  • 103. Chao A. C., de Sauvage F. J., Dong Y.-J., Wagner J. A., Goeddel D. V.Gardner P., EMBO J., 13, 1065 - 1072 (1994), "Activation of Intestinal CFTR Cl- Channel by Heat - stable Enterotoxin and Guanylin Via cAMP - dependent Protein Kinase"
  • 104. Cornwell T. L., Arnold E., Boerth N. J.Lincoln T. M., Am. J. Physiol., 267, 1405 - 1413 (1994), "Inhibition of Smooth Muscle Cell Growth by Nitric Oxide and Activation of cAMP-dependent Protein Kinase by cGMP"
  • 105. Nakazawa M.Imai S., Eur. J. Pharmacol., 253, 179 - 181 (1994), "Rp-8-Br-Guanosine- 3', 5'- cyclic Monophosphorothioate Inhibits Relaxation Elicited by Nitroglycerin in Rabbit Aorta"
  • 106. Meriney S. D., Gray D. B.Pilar G. R., Nature, 369, 336 - 339 (1994), "Somatostatin-Induced Inhibition of Neuronal Ca 2+ Current Modulated by cGMP-dependent Protein Kinase"
  • 107. Meriney S. D., Gray D. B.Pilar G. R., Nature, 371, 812 - 0 (1994), "Somatostatin-Induced Inhibition of Neuronal Ca 2+ Current Modulated by cGMP-dependent Protein Kinase (Correction)"
  • 108. Ouedraogo S., Stoclet J.-C.Bucher B., Br. J. Pharmacol., 112, 867 - 872 (1994), "Effects of cyclic GMP and Analogues on Neurogenic Transmission in the Rat Tail Artery"
  • 109. Bowler C., Neuhaus G., Yamagata H.Chus N.-H., Cell, 77, 73 - 81 (1994), "Cyclic GMP and Calcium Mediate Phytochrome Phototransduction"
  • 110. Cabrera C.Bohr D., IUPHAR Satellite Symp. Nitric Oxide in the Nervous System Montreal/Canada, 0, 0 - 0 (1994), "Central Nitric Oxide in the Regulation of Blood Pressure"
  • 111. Ohigashi T., Brookins J.Fisher J. W., J. Clin. Invest., 92, 1587 - 1591 (1994), "Interaction of Nitric Oxide and Cyclic Guanosine 3', 5'- Monophosphate in Erythropoietin Production"
  • 112. Zhuo M., Hu Y., Schultz C., Kandel E. R.Hawkins R. D., Nature, 368, 635 - 639 (1994), "Role of Guanylyl Cyclase and cGMP-dependent Protein Kinase in Long-term Potentiation"
  • 113. Hawkins R. D., Zhuo M.Arancio O., J. Neurobiol., 27, 652 - 665 (1994), "Nitric Oxide and Carbon Monoxide as Possible Retrograde Messengers in Hippocampal Long-Term Potentiation"
  • 114. Tang K. M., Sheerwood J. L.Haslam R. J., Biochem. J., 294, 329 - 333 (1993), "Photoaffinity Labelling of Cyclic GMP-binding Proteins in Human Platelets"
  • 115. Klyszcz-Nasko H., Richter-Landsberg C.Beyersmann D., Arch. Biochem. Biophys., 306, 383 - 390 (1993), "Modulation of Bradykinin-induced Calcium Signals by Oxidative Stress in PC12 Cells"
  • 116. Moretto M., Lopez F. J.Negro-Vilar A., Endocrinology, 133, 2399 - 2402 (1993), "Nitric Oxide Regulates Luteinizing Hormone-releasing Hormone Secretion"
  • 117. Brown J. F., Hanson P. J.Whittle B. J. R., Biochem. Biophys. Res. Commun., 195, 1354 - 1359 (1993), "The Nitric Oxide Donor, S-Nitroso-N-acetyl-penicillamine, Inhibits Secretory Activity in Rat Isolated Parietal Cells"
  • 118. Jastorff B., Proceeding of the 8th. Internatl. Conference on Second Messengers & Phosphoproteins UK, 0, 0 - 0 (1992), "A New Generation of Cyclic Nucleotide Analogues : Site Specific, Enzyme Selective, Agonistic or Antagonistic and Resistant to Hydrolysis"

Show more