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Alternative structural projections:

Rp-8-Br-cAMPS

8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-cAMPS ), sodium salt
Lipophilic analogue of the cyclic AMP antagonist Rp-cAMPS
Cat. No.: B 001
    
CAS No.: [129735-00-8]
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Product Name Price (net) Qty
Cat. No.: B 001-05
Unit: 5 µmol / ~2.2 mg
$330.00
For other salt forms please inquire. Lipophilic analogue of the cyclic AMP antagonist Rp-cAMPS. Prefers type I of protein kinase A. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane-permeant compared to Rp-cAMPS (Cat. No. A 002) or 8-Br-cAMP (Cat. No. B 007). Detailed technical information and updated reference list available on request. References: Gjertsen et al., J. Biol. Chem., 270, 20599 - 20607 (1995), Aandahl et al., FASEB J., 12, 855 - 863 (1998).
Cat. No. B 001
CAS number [129735-00-8]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₀BrN₅O₅PS · Na
Molecular weight [g/mol] 446,2
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 1.47
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
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