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Alternative structural projections:

Rp-8-AEA-cAMPS

8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-AEA-cAMPS )
Cat. No.: A 180
    
CAS No.: [221904-78-5]
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Cat. No.: A 180-05
Unit: 5 µmol
$363.00
Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers. Detailed technical information available. This ligand is also available with a longer spacer (Rp-8-AHA-cAMPS; Cat. No. A 085), and immobilized on agarose gel (Rp-8-AEA-cAMPS-Agarose; Cat. No. A 007).
Cat. No. A 180
CAS number [221904-78-5]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₈N₇O₅PS
Molecular weight [g/mol] 403,4
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 0.69
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Dutta S. P., Mittelman A.Chheda G. B., Biochem. Med., 23, 179 - 184 (1980), "Metabolism of 1,N6-Ethenoadenosine"
  • 2. Mian A. M., Harris R., Sidwell R. W., Robins R. K.Khwaja T. A., J. Med. Chem., 17, 259 - 2663 (1974), "Synthesis and Biological Activity of 9-β-D- Arabinofuranosyladenine Cyclic 3', 5'- Phosphate and 9-β-D- Arabinofuranosylguanine Cyclic 3', 5'- Phosphate"