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Rp-6-Cl-cPuMPS

6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-6-Cl-cPuMPS ), sodium salt
Cat. No.: C 082
    
CAS No.: [129693-15-8]
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Cat. No.: C 082-05
Unit: 5 µmol
$330.00
PDE-resistant modulator of protein kinase A with reactive functional group allowing further chemical modifications. Significantly more lipophilic and membrane-permeant compared to Rp-cAMPS (Cat. No. A 002). Detailed technical information available. Reference: Dostmann et al., J. Biol. Chem., 265, 10484 - 10491 (1990).
Cat. No. C 082
CAS number [129693-15-8]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₉ClN₄O₅PS · Na
Molecular weight [g/mol] 386,7
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Lipophilicity 1.46
Absorption max [nm] 263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 8900
  • 1. Dostmann W. R. G., Taylor S. S., Genieser H.-G., Jastorff B., Doeskeland S. O.Oegreid D., J. Biol. Chem., 265, 10484 - 10491 (1990), "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"