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Alternative structural projections:

Rp-5,6-DCl-cBIMPS

5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-5,6-DCl-cBIMPS ), sodium salt
 
Cat. No.: D 013
    
CAS No.: [120912-55-2]
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Product Name Price (net) Qty
Cat. No.: D 013-05
Unit: 5 µmol / ~2.1 mg
$220.00
Lipophilic and phosphodiesterase-resistant modulator of cAMP-dependent protein kinase. The corresponding Sp- isomer is available as well (Cat. No. D 014). Detailed technical information and references available. Reference: Dostmann et al., J. Biol. Chem., 265, 10484 - 10491 (1990).
Cat. No. D 013
CAS number [120912-55-2]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₀Cl₂N₂O₅PS · Na
Molecular weight [g/mol] 419,2
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 1-cAMP, 2-cAMP, 3-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 2.87
Absorption max [nm] 254
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 6400
  • 1. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 2. Harayama H.Miyake M., Mol. Reprod. Dev., 73, 1169 - 1178 (2006), "A Cyclic Adenosine 3 ',5 '-monophosphate-dependent Protein Kinase C Activation is Involved in the Hyperactivation of Boar Spermatozoa"
  • 3. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 4. Dostmann W. R. G., Taylor S. S., Genieser H.-G., Jastorff B., Doeskeland S. O.Oegreid D., J. Biol. Chem., 265, 10484 - 10491 (1990), "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"