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8-OH-Guo

8- Hydroxyguanosine ( 8-OH-Guo )
Cat. No.: H 001
    
CAS No.: [3868-31-3]
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Product Name Price (net) Qty
Cat. No.: H 001-05
Unit: 5 µmol / ~1.5 mg
$118.00
Reference for analysis of oxidative stress RNA hydrolysates. The corresponding nucleobase (Cat. No. H 002) is available as well. For other 8-OH-nucleosides and nucleotides please inquire. Detailed technical information available. Reference: Takeuchi et al, Carcinogenesis 14, 1115 - 1120 (1993).
Libri compound library (K 001)
Cat. No. H 001
CAS number [3868-31-3]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₃N₅O₆
Molecular weight [g/mol] 299.3
Absorption max [nm] 245/293
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 12300 / 10300
  • 1. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"
  • 2. Takeuchi T.Morimoto K., Carcinogenesis, 14, 1115 - 1120 (1993), "Increased Formation of 8-Hydroxydeoxyguanosine, an Oxidative DNA Damage, in Lymphoblasts from Fanconi's Anemia Patients Due to Possible Catalase Deficiency"
  • 3. Cho B. P., Kadlubar F. F., Culp S. J.Evans F. E., Chem. Res. Toxicol., 3, 445 - 452 (1990), "15N Nuclear Magnetic Resonance Studies on the Tauterism of 8-Hydroxy-2'-deoxyguanosine, 8-Hydroxyguanosine, and Other C8-substituted Guanine Nucleosides"
  • 4. Rannels S. R.Corbin J. D., J. Biol. Chem., 255, 7085 - 7088 (1980), "Two Different Intrachain cAMP Binding Sites of cAMP-Dependent Protein Kinases"