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Alternative structural projections:

Sp-5,6-DCl-cBIMPS

5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-5,6-DCl-cBIMPS ), sodium salt
Powerful PDE-resistant and membrane-permeant PKA agonist
Cat. No.: D 014
    
CAS No.: [120912-54-1]
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Product Name Price (net) Qty
Cat. No.: D 014-05
Unit: 5 µmol / ~2.1 mg
$220.00
For other salt forms please inquire. Potent site-selective activator of cAMP- dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian PDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency. The corresponding Rp- isomer is available as well (Cat. No. D 013). Detailed technical information and updated reference list available. References: Sandberg et al., Biochemistry, 279, 521 - 527 (1991); Maronde et al., J. Pineal Res., 27, 170 - 182 (1999); Poppe et al., Nature Methods, 5, 277 - 278 (2008).
Cat. No. D 014
CAS number [120912-54-1]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₀Cl₂N₂O₅PS · Na
Molecular weight [g/mol] 419.2
Modifications 1-cAMP, 2-cAMP, 3-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.99
Absorption max [nm] 254
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 6400
  • 1. Gausdal G., Wergeland A., Skavland J., Nguyen E., Pendino F., Rouhee N., McCormack E., Herfindal L., Kleppe R., Havemann U., Schwede F., Bruseud O., Gjertsen B. T., Lanotte M., Segal-Bendirdjian E.Doskeland S. O., Cell Death Dis., 4, 0 - 0 (2013), "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
  • 2. Herfindal L., Nygaard G., Kopperud R., Krakstad C., Doeskeland S. O.Selheim F., Biochem. Biophys. Res. Commun., 437, 603 - 608 (2013), "Off-Target Effect of the Epac Agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 Receptors in Blood Platelets"
  • 3. Huseby S., Gausdal G., Keen T. J., Kjærland E., Krakstad C., Myhren L., Brønstad K., Kunick C., Schwede F., Genieser H.-G., Kleppe R.Doeskeland S. O., Cell Death Dis., e237, 2, 0 - 0 (2011), "Cyclic AMP Induces IPC Leukemia Cell Apoptosis via CRE-and CDK-dependent Bim Transcription"
  • 4. Werner K., Schwede F., Genieser H.-G., Geiger J.Butt E., Naunyn Schmiedebergs Arch. Pharmacol., 384, 169 - 176 (2011), "Quantification of cAMP and cGMP Analogs in Intact Cells: Pitfalls in Enzyme Immunoassays for Cyclic Nucleotides"
  • 5. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 6. Poppe H., Rybalkin S. D., Rehmann H., Hinds T. R., Tang X.-B., Christensen A. E., Schwede F., Genieser H.-G., Bos J. L., Doeskeland S. O., Beavo J. A.Butt E., Nature Methods, 5, 277 - 278 (2008), "Cyclic Nucleotide Analogs as Probes of Signaling Pathways"
  • 7. Moll D., Prinz A., Brendel C. M., Berrera M., Guske K., Zaccolo M., Genieser H.-G.Herberg F. W., BMC Biochem., 9, 18 - 18 (2008), "Biochemical Characterization and Cellular Imaging of a Novel, Membrane Permeable Fluorescent cAMP Analog"
  • 8. Antl M., von Brühl M.-L., Eiglsperger C., Werner M., Konrad I., Kocher T., Wilm M., Hofmann F., Massberg S.Schlossmann J., Blood, 109, 552 - 559 (2007), "IRAG Mediates NO/cGMP-dependent Inhibition of Platelet Aggregation and Thrombus Formation"
  • 9. Pfitzer G., Lubomirov L. T., Reimann K., Gagov H.Schubert R., J. Muscle Res. Cell Motil., 27, 445 - 454 (2006), "Regulation of the Crossbridge Cycle in Vascular Smooth Muscle by cAMP Signalling"
  • 10. Gambaryan S., Butt E., Tas P., Smolenski A., Allolio B.Walter U., Am. J. Physiol. Endocrinol. Metab. E, 290, 423 - 433 (2006), "Regulation of Aldosterone Production from Zona Glomerulosa Cells by Ang II and cAMP: Evidence for PKA Independent Activation of CaMK by cAMP"
  • 11. Lubomirov L. T., Reimann K., Metzler D., Hasse V., Stehle R., Ito M., Hartshorne D. J., Gagov H., Pfitzer G.Schubert R., Circ. Res., 98, 1159 - 1167 (2006), "Urocortin-induced Decrease in Ca2+ Sensitivity of Contraction in Mouse Tail Arteries is Attributable to cAMP-dependent Dephosphorylation of MYPT1 and Activation of Myosin Light Chain Phosphatase"
  • 12. Harayama H.Miyake M., Mol. Reprod. Dev., 73, 1169 - 1178 (2006), "A Cyclic Adenosine 3 ',5 '-monophosphate-dependent Protein Kinase C Activation is Involved in the Hyperactivation of Boar Spermatozoa"
  • 13. Kwong K.Lee l. Y., J. Physiol., 564, 437 - 450 (2005), "Prostaglandin E-2 Potentiates a TTX-resistant Sodium Current in Rat Capsaicin-sensitive Vagal Pulmonary Sensory Neurones"
  • 14. Harrison R. A. P., Mol. Reprod. Dev., 67, 337 - 352 (2004), "Rapid PKA-catalysed Phosphorylation of Boar Sperm Proteins Induced by the Capacitating Agent Bicarbonate"
  • 15. Makarevich A. V., Sirotkin A. V.Genieser H.-G., Anim. Reprod. Sci., 81, 125 - 136 (2004), "Action of Protein Kinase A Regulators on Secretory Activity of Porcine Granulosa Cells in Vitro"
  • 16. Boczan J., Leenders A. G. M.Sheng Z. H., J. Biol. Chem., 279, 18911 - 18919 (2004), "Phosphorylation of Syntaphilin by cAMP-dependent Protein Kinase Modulates its Interaction with Syntaxin-1 and Annuls its Inhibitory Effect on Vesicle Exocytosis"
  • 17. Dyachok O.Gylfe E., J. Biol. Chem., 279, 45455 - 45461 (2004), "Ca2+-induced Ca2+ Release via Inositol 1,4,5-triphosphate Receptors is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic Beta-cells"
  • 18. Harayama H., Sasaki K.Miyake M., Mol. Reprod. Dev., 69, 194 - 204 (2004), "A Unique Mechanism for cyclic Adenosine 3' , 5'-monophosphate-induced Increase of 32-kDa Tyrosine-phosphorylated Protein in Boar Spermatozoa"
  • 19. Murthy K. S., Neurochem. Int., 45, 845 - 851 (2004), "Modulation of Soluble Guanylate Cyclase Activity by Phosphorylation"
  • 20. Nguyen G. H., French R.Radhakrishna H., Cell Signal., 16, 1141 - 1151 (2004), "Protein Kinase A Inhibits Lysophosphatidic Acid Induction of Serum Response Factor via Alterations in the Actin Cytoskeleton"
  • 21. Kloss S., Srivastava R.Mülsch A., Mol. Pharmacol., 65, 1440 - 1451 (2004), "Down-regulation of Soluble Guanylyl Cyclase Expression by Cyclic AMP is Mediated by mRNA-stabilizing Protein HuR"
  • 22. Fricke K., Heitland A.Maronde E., Endocrinology, 145, 4940 - 4947 (2004), "Cooperative Activation of Lipolysis by Protein Kinase A and Protein Kinase C Pathways in 3T3-L1 Adipocytes"
  • 23. Jensen B. O., Selheim F., Doeskeland S. O., Gear A. R. L.Holmsen H., Blood, 104, 2775 - 2782 (2004), "Protein Kinase A Mediates Inhibition of the Thrombin-Induced Platelet Shape Change by Nitric Oxide"
  • 24. Mutafova-Yambolieva V. N., Smyth L.Bobalova J., Cardiovasc. Res., 57, 217 - 224 (2003), "Involvement of Cyclic AMP-mediated Pathway in Neural Release of Noradrenaline in Canine Isolated Mesenteric Artery and Vein"
  • 25. Kopperud R. K., Krakstad C., Selheim F.Doeskeland S. O., FEBS Lett., 546, 121 - 126 (2003), "cAMP Effector Mechanisms. Novel Twists for an 'Old' Signaling System"
  • 26. Christensen A. E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K. K., Martinez A., Maenhaut C., Bos J. L., Genieser H.-G.Doeskeland S. O., J. Biol. Chem., 278, 35394 - 35402 (2003), "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
  • 27. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 28. Harayama H., J. Androl., 24, 831 - 842 (2003), "Viability and Protein Phosphorylation Patterns of Boar Spermatozoa Agglutinated by Treatment with a Cell-permeable Cyclic Adenosine 3' , 5'-monophosphate Analog"
  • 29. Harayama H., Okada K.Miyake M., J. Androl., 24, 91 - 99 (2003), "Involvement of Cytoplasmic Free Calcium in Boar Sperm: Head-to-head Agglutination Induced by a Cell-Permeable Cyclic Adenosine Monophosphate Analog"
  • 30. Vargas G.Lucero M. T., J. Membrane Biol., 188, 115 - 125 (2002), "Modulation by PKA of the Hyperpolarization-activated Current (I-h) in Cultured Rat Olfactory Receptor Neurons"
  • 31. Christensen A. E., de Rooij J., Kopperud R. K., Nilsen O. K., Dao K. K., Schwede F., Bos J. L., Genieser H.-G.Doeskeland S. O., Abstract of the 13th Protein Kinase Symposium, 0, 5 - 5 (2002), "Comparison of the cAMP Binding Sites of EPAC-1 and cAMP-Kinase"
  • 32. Murthy K. S., Zhou H. P.Makhlouf G. M., Am. J. Physiol.-Cell Physiol., 282, 508 - 517 (2002), "PKA-dependent Activation of PDE3A and PDE4 and Inhibition of Adenylyl Cyclase V/VI in Smooth Muscle"
  • 33. Wollert K. C., Fiedler B., Gambaryan S., Smolenski A., Heineke J., Butt E., Trautwein C., Lohmann S. M.Drexler H., Hypertension, 39, 87 - 92 (2002), "Gene Transfer of cGMP-dependent Protein Kinase I Enhances the Antihypertrophic Effects of Nitric Oxide in Cardiomyocytes"
  • 34. Locatelli F., Maldonado H.Romano A., Neurobiol. Learn. Mem., 77, 234 - 249 (2002), "Two Critical Periods for cAMP-dependent Protein Kinase Activity During Long-Term Memory Consolidation in the Crab Chasmagnathus"
  • 35. Popp R., Brandes R. P., Ott G., Busse R.Fleming I., Circ. Res., 90, 800 - 806 (2002), "Dynamic Modulation of Interendothelial Gap Junctional Communication by 11, 12-Epoxyeicosatrienoic Acid"
  • 36. Holt W. V.Harrison R. A. P., J. Andrology, 23, 557 - 565 (2002), "Bicarbonate Stimulation of Boar Sperm Motility via a Protein Kinase A-dependent Pathway: Between-Cell and Between-Ejaculate Differences are not Due to Deficiencies in Protein Kinase A Activation"
  • 37. Jang E. K., Azzam J. E., Dickinson N. T., Davidson M. M. L.Haslam R. J., Brit. J. Haematol., 117, 664 - 675 (2002), "Roles for Both Cyclic GMP and Cyclic AMP in the Inhibition of Collagen-induced Platelet Aggregation by Nitroprusside"
  • 38. Loir M., Mol. Reprod. Dev., 58, 307 - 317 (2001), "Adenosine Receptor-Adenylate Cyclase System in the Trout Testis: Involvement in the Regulation of Germ Cell Proliferation"
  • 39. Marienfeld U., Walter U.Simm A., Basic Res. Cardiol., 96, 184 - 191 (2001), "Inhibition of Rat Cardiac Fibroblast Growth by cAMP- but not by cGMP-dependent Protein Kinase"
  • 40. Mokh V. P., Shubert R.Serebryakov V. N., Biol. Membr., 18, 3 - 9 (2001), "Action of the Permeable Analogs of cAMP and cGMP on the Dilayed Rectifier Ionic Currents in Isolated Smooth Muscle Cells of Rat Mesenteric Artery"
  • 41. Maronde E., Korf H. W., Niemann P.Genieser H.-G., J. Pineal Res., 31, 183 - 185 (2001), "Direct Comparison of the Potency of Three Novel cAMP Analogs to Induce CREB-Phosphorylation in Rat Pinealocytes"
  • 42. Maurice N., Tkatch T., Meisler M., Sprunger L. K.Surmeier D. J., J. Neurosci., 21, 2268 - 2277 (2001), "D1/D5 Dopamine Receptor Activation Differentially Modulates Rapidly Inactivating and Persistent Sodium Currents in Prefrontal Cortex Pyramidal Neurons"
  • 43. Murthy K. S., Biochem. J., 360, 199 - 208 (2001), "Activation of Phosphodiesterase 5 and Inhibition of Guanylate Cyclase by cGMP-dependent Protein Kinase in Smooth Muscle"
  • 44. Lubomirov L., Gagov H., Petkova-Kirova P., Duridanova D., Kalentchuk V. U.Schubert R., Br. J. Pharmacol., 134, 1564 - 1570 (2001), "Urocortin Relaxes Rat Tail Arteries by a PKA-mediated Reduction of the Sensitivity of the Contractile Apparatus for Calcium"
  • 45. Truss M. C., Stief C. G., Jonas U., Ückert S., Becker A. J.Forssmann W.-G., Deutsche Offenlegungsschrift, 0, 0 - 0 (2001), "Verwendung von Substanzen, die den intrazellulären Gehalt von zyklischem Adenosinmonophosphat (cAMP) erhöhen oder die Aktivität cAMP-bindender Proteine stimulieren, zur Behandlung von Erkrankungen der Harnblase"
  • 46. von der Weid P. Y., Zhao J.Ven Helden D. F., Am. J. Physiol.-Heart Circul. Physiol., 280, 2707 - 2716 (2001), "Nitric Oxide Decreases Pacemaker Activity in Lymphatic Vessels of Guinea Pig Mesentery"
  • 47. Han J., Kim N., Kim E., Ho W.-K.Earm Y. E., J. Biol. Chem., 276, 22140 - 22147 (2001), "Modulation of ATP-sensitive Potassium Channels by cGMP-dependent Protein Kinase in Rabbit Ventricular Myocytes"
  • 48. Butt E., Bernhardt M., Smolenski A., Kotsonis P., Fröhlich L. G., Sickmann A., Meyer H. E., Lohmann S. M.Schmidt H. H. H. W., J. Biol. Chem., 275, 5179 - 5187 (2000), "Endothelial Nitric-Oxide Synthase (Type III) is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-Dependent Protein Kinases"
  • 49. Harrison R. A. P.Miller N. G. A., Mol. Reprod. Dev., 55, 220 - 228 (2000), "cAMP-Dependent Protein Kinase Control of Plasma Membrane Lipid Architecture in Boar Sperm"
  • 50. Flores-Hernandez J., Hernandez S., Snyder G. L., Yan Z., Fienberg A. A., Moss S. J., Greengard P.Surmeier D. J., J. Neurophysiol., 83, 2996 - 3004 (2000), "D-1 Dopamine Receptor Activation Reduces GABA(A) Receptor Currents in Neostriatal Neurons through a PKA/DARPP-32/PP1 Signaling Cascade"
  • 51. Christensen A., Dao K. K., Doeskeland S. O., Schwede F., Jastorff B., Genieser H.-G., de Rooij J., Bos J. L., Rehmann H., Kraemer A.Wittinghofer A., 12th Protein Kinase Symp. NO/cGMP and Protein Kinase Signaling Bad Brückenau/Germany, 0, 0 - 0 (2000), "8-Modified cAMP Analogs give Insight into the Geometries of the cAMP Binding Sites of RI, RII and EPAC-1"
  • 52. Ebinger M., Jehle D. R., Fussgaenger R. D., Fehmann H. C.Jehle P. M., Am. J. Physiol. - Endocrinol. Met., 279, 88 - 94 (2000), "Glucagon-like Peptide-1 Improves Insulin and Proinsulin Binding on RINm5F Cells and Human Monocytes"
  • 53. Li J., Yang S.Billiar T. R., J. Biol. Chem., 275, 13026 - 13034 (2000), "Cyclic Nucleotides Suppress Tumor Necrosis Factor Alpha-Mediated Apoptosis by Inhibiting Caspase Activation and Cytochrome c Release in Primary Hepatocytes via a Mechanism Independent of Akt Activation"
  • 54. Bradbury N. A., J. Cell. Physiol., 185, 408 - 415 (2000), "Protein Kinase-A-mediated Secretion of Mucin from Human Colonic Epithelial Cells"
  • 55. Björklund A.Grill V. E., J. Endocrinol., 166, 537 - 544 (2000), "Relief from Glucose-induced Over-Stimulation Sensitizes the Adenylate Cyclase-cAMP System of Rat Pancreatic Islets"
  • 56. Osinski M., Ph.D. Thesis Düsseldorf/Germany, 0, 0 - 0 (2000), "Pharmakologische Ansätze einer Proteinkinase A-Aktivierung zur Hemmung der Mitogenese glatter Gefäßmuskelzellen"
  • 57. Prieto D., Buus C. L., Mulvany M. J.Nilsson H., Br. J. Pharmacol., 129, 1689 - 1699 (2000), "Neuropeptide Y Regulates Intracellular Calcium through Different Signalling Pathways Linked to a Y1-Receptor in Rat Mesenteric Small Arteries"
  • 58. Pfeffer M., Maronde E., Korf H.-W.Stehle J. H., J. Pineal Res., 29, 24 - 33 (2000), "Antisense Experiments Reveal Molecular Details on Mechanism of ICER Suppressing cAMP-inducible Genes in Rat Pinealocytes"
  • 59. Pfeffer M., Maronde E., Molina C. A., Korf H.-W.Stehle J. H., Mol. Pharmacol., 56, 279 - 289 (1999), "Inducible cyclic AMP early repressor protein in rat pinealocytes: A highly sensitive natural reporter for regulated gene transcription"
  • 60. Maronde E., Wicht H., Tasken K., Genieser H.-G., Dehghani F., Olcese J.Korf H.-W., J. Pineal Res., 27, 170 - 182 (1999), "CREB Phosphorylation and Melatonin Biosynthesis in the Rat Pineal Gland: Involvement of cyclic AMP-dependent Protein KinaseType II"
  • 61. Ruth P., Pharmacol. Ther., 82, 355 - 372 (1999), "Cyclic GMP-Dependent Protein Kinases: Understanding in vivo Functions by Gene Targeting"
  • 62. McMartin L.Summers R. J., Br. J. Pharmacol., 127, 1012 - 1020 (1999), "Functional Analysis of Desensitization of the Beta-Adrenoceptor Signalling Pathway in Rat Cardiac Tissues Following Chronic Isoprenaline Infusion"
  • 63. Schubert R., Lehmann G., Serebryakov V. N., Mewes H.Hopp H.-H., Am. J. Physiol.-Heart Circul. Physiol., 46, 1145 - 1155 (1999), "cAMP-Dependent Protein Kinase is in an Active State in Rat Small Arteries Possessing a Myogenic Tone"
  • 64. Cantrell A. R., Tibbs V. C., Westenbroek R. E., Scheuer T.Catterall W. A., J. Neurosci., 19, 1 - 6 (1999), "Dopaminergic Modulation of Voltage-Gated Na+ Current in Rat Hippocampal Neurons Requires Anchoring of cAMP-Dependent Protein Kinase"
  • 65. Massberg S., Sausbier M., Klatt P., Bauer M., Pfeifer A., Siess W., Fessler R., Ruth P., Krombach F.Hofmann F., J. Exp. Med., 189, 1255 - 1263 (1999), "Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3', 5'-Monophosphate Kinase I"
  • 66. Cantrell A. R., Scheuer T.Catterall W. A., J. Neurosci., 19, 5301 - 5310 (1999), "Voltage-Dependent Neuromodulation of Na+ Channels by D1-Like Dopamine Receptors in Rat Hippocampal Neurons"
  • 67. Klages B., Brandt U., Simon M. I., Schultz G.Offermanns S., J. Cell Biol., 144, 745 - 754 (1999), "Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase-Mediated Myosin Light Chain Phosphorylation in Mouse Platelets"
  • 68. Pfeifer A., Ruth P., Dostmann W., Sausbier M., Klatt P.Hofmann F., in Rev. Physiol. Biochem. Pharmacol. Berlin / Springer, 135, 105 - 149 (1999), "Structure and Function of cGMP-Dependent Protein Kinases"
  • 69. Sirotkin A., Makarevic A., Kotwica J., Genieser H.-G.Bulla J., J. Farm. Animal. Sci., 32, 11 - 14 (1999), "Effect of Chemical Analogues of cAMP and cGMP on Hormone and Growth Factor Secretion by Porcine Ovarian Cells"
  • 70. Gantner F., Gotz C., Gekeler V., Schudt C., Wendel A.Hatzelmann A., Br. J. Pharmacol., 123, 1031 - 1038 (1998), "Phosphodiesterase Profile of Human B Lymphocytes from Normal and Atopic Donors and the Effects of PDE Inhibition on B Cell Proliferation"
  • 71. Garcia-Ocana A., Gomez-Casero E., Penaranda C.Esbrit P., Life Sci., 62, 2267 - 2273 (1998), "Parathyroid Hormone-related Protein Increases DNA Synthesis in Proximal Tubule Cells by Cyclic AMP- and Protein Kinase C-dependent Pathways"
  • 72. Murthy K. S.Makhlouf G. M., J. Biol. Chem., 273, 34519 - 34526 (1998), "Differential Regulation of Phospholipase A(2)(PLA(2))-Dependent Ca2+Signaling in Smooth Muscle by cAMP- and cGMP-Dependent Protein Kinases - Inhibitory Phosphorylation of PLA(2) by Cyclic Nucleotide-Dependent Protein Kinases"
  • 73. Smolenski A., Bachmann C., Reinhard K., Hönig-Liedl P., Jarchau T., Hoschuetzky H.Walter U., J. Biol. Chem., 273, 20029 - 20035 (1998), "Analysis and Regulation of Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation In Vitro and in Intact Cells Using a Phosphospecific Monoclonal Antibody"
  • 74. Singh A. K., Tasken K., Walker W., Frizzell R. A., Watkins S. C., Bridges R. J.Bradbury N. A., Am. J. Physiol., 275, 562 - 570 (1998), "Characterization of PKA Isoforms and Kinase-dependent Activation of Chloride Secretion in T84 Cells"
  • 75. Maronde E., Middendorff R., Telgmann R., Müller D., Hemmings B., Tasken K.Olcese J., J. Neurochem., 68, 770 - 777 (1997), "Melatonin Synthesis in the Bovine Pineal Gland is Regulated by Type II Cyclic AMP-Dependent Protein Kinase"
  • 76. Johnson B. D., Brousal J. P., Peterson B. Z., Gallombardo P. A., Hockerman G. H., Lai Y., Scheuer T.Catterall W. A., J. Neurosci., 17, 1243 - 1255 (1997), "Modulation of the Cloned Skeletal Muscle L-Type CA2+ Channel by Anchored cAMP-Dependent Protein Kinase"
  • 77. Schubert R., Serebryakov V. N., Mewes H.Hopp H.-H., Amer. J. Physiol.- Heart Circ. Phy., 41, 1147 - 1156 (1997), "Iloprost Dilates Rat Small Arteries - Role of K-ATP- and K-CA-Channel Activation by cAMP-Dependent Protein Kinase"
  • 78. Torgersen K. M., Vaage J. T., Levy F. O., Hansson V., Rolstad B.Tasken K., J. Biol. Chem., 272, 5495 - 5500 (1997), "Selective Activation of cAMP-Dependent Protein Kinase Type I Inhibits Rat Natural Killer Cell Cytotoxicity"
  • 79. Weissinger E. M., Eissner G., Grammer C., Fackler S., Haefner B., Yoon L. S., Lu K. S., Bazarow A., Sedivy J. M., Mischak H.Kolch W., Mol. Cell. Biol., 17, 3229 - 3241 (1997), "Inhibition of the Raf-1 Kinase by Cyclic AMP Agonists Causes Apoptosis of v-abl-Transformed Cells"
  • 80. Prieto D., Buus C., Mulvany M. J.Nilsson H., J. Physiol., 502, 281 - 292 (1997), "Interactions Between Neuropeptide Y and the Adenylate Cyclase Pathway in Rat Mesenteric Small Arteries - Role of Membrane Potential"
  • 81. Cantrell A. R., Smith R. D., Goldin A. L., Scheuer T.Catterall W. A., J. Neurosci., 17, 7330 - 7338 (1997), "Dopaminergic Modulation of Sodium Current in Hippocampal Neurons via cAMP-Dependent Phosphorylation of Specific Sites in the Sodium Channel Alpha Subunit"
  • 82. Cheng X.-J., Höög J.-O., Nairn A. C., Greengard P.Aperia A., Am. J. Physiol., 273, 1981 - 1986 (1997), "Regulation of Rat Na+-, K+- ATPase Activity by PKC is Modulated by State of Phosphorylation of Ser-943 by PKA"
  • 83. Krass J. D., Jastorff B.Genieser H.-G., Anal. Chem., 69, 2575 - 2581 (1997), "Determination of Lipophilicity by Gradient Elution High-Performance Liquid Chromatography"
  • 84. Bolz S. S.Pohl U., Cardiovasc. Res., 36, 437 - 444 (1997), "Indomethacin Enhances Endothelial No Release-Evidence for a Role Of PGI(2) in the Autocrine Control of Calcium-Dependent Autacoid Production"
  • 85. Maldonado H., Romano A.Tomsic D., Braz. J. Med. Biol. Res., 30, 813 - 826 (1997), "Long-term Habituation (LTH) in the Crab Chasmagnathus: a Model for Behavioral and Mechanistic Studies of Memory"
  • 86. Mutafova-Yambolieva V. N.Keef K. D., Amer. J. Physiol.-Heart Circ. Physiol., 42, 2687 - 2695 (1997), "Adenosine-Induced Hyperpolarization in Guinea Pig Coronary Artery Involves A(2B) Receptors and K-ATP Channels"
  • 87. Wayman G. A., Tokumitsu H.Soderling T. R., J. Biol. Chem., 272, 16073 - 16076 (1997), "Inhibitory Cross-Talk by cAMP Kinase on the Calmodulin-dependent Protein Kinase Cascade"
  • 88. Tenor H., Hatzelmann A., Church M. K., Schudt C.Shute J. K., Br. J. Pharmacol., 118, 1727 - 1735 (1996), "Effects of Theophylline and Rolipram on Leukotriene C4 (LTC4) Synthesis and Chemotaxis of Human Eosinophils from Normal and Atopic Subjects"
  • 89. Holen I., Gordon P. B., Stroemhaug P. E.Seglen P. O., Eur. J. Biochem., 236, 163 - 170 (1996), "Role of cAMP in the Regulation of Hepatocytic Autophagy"
  • 90. Raman I. M., Tong G.Jahr C. E., Neuron, 16, 415 - 421 (1996), "Beta-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase"
  • 91. Schubert R., Serebryakov V. N., Engel H.Hopp H.-H., Am. J. Physiol., 271, 1203 - 1211 (1996), "Iloprost Activates Kca Channels of Vascular Smooth Muscle Cells: Role of cAMP-dependent Protein Kinase"
  • 92. Sirotkin A. V., Makarevic A. V.Genieser H.-G., 3rd Intl. Conf. Cyclic Nucleotide Phosphodiesterases ( From Genes to Therapies ) Scotland, 0, 0 - 0 (1996), "The Effect of PDE Inhibitors and Other Regulators of PKA on the Secretory Activity of Porcine Ovarian Granulosa Cells"
  • 93. De Jongh K. S., Murphy B. J., Colvin A. A., Hell J. W., Takahashi M.Catterall W. A., Biochemistry, 35, 10392 - 10402 (1996), "Specific Phosphorylation of a Site in the Full-Length Form of the @1 Subunit of the Cardiac L-Type Calcium Channel by Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase"
  • 94. Azula F. J., Alzola E. S., Conde M., Trueba M., Macarulla J. M.Marino A., Mol. Pharmacol., 50, 367 - 379 (1996), "Thrombin-stimulated Phospholipase C Activity is Inhibited Without Visible Delay by a Rapid Increase in the Cyclic GMP Levels Induced by Sodium Nitroprusside"
  • 95. Fehmann H. C., Jiang J. W., Pitt D., Schweinfurth J.Göke B., Pancreas, 13, 273 - 282 (1996), "Ligand-induced Regulation of Glucagon-like Peptide-I Receptor Function and Expression in Insulin-secreting Beta-Cells"
  • 96. Romano A., Locatelli F., Delorenzi A., Pedreira M. E.Maldonado H., Brain Res., 735, 131 - 140 (1996), "Effects of Activation and Inhibition of cAMP-dependent Protein Kinase on Long-term Habituation in the Crab Chasmagnathus"
  • 97. el-Daher S. S., Eigenthaler M., Walter U., Furuichi T., Miyawaki A., Mikoshiba K., Kakkar V. V.Authi K. S., Thrombosis & Haemostasis, 76, 1063 - 1071 (1996), "Distribution and Activation of cAMP- and cGMP-Dependent Protein Kinases in Highly Purified Human Platelet Plasma and Intracellular Membranes"
  • 98. Murphy-Ullrich J. E., Pallero M. A., Boerth N., Greenwood J. A., Lincoln T. M.Cornwell T. L., J. Cell Sci., 109, 2499 - 2508 (1996), "Cyclic GMP-dependent Protein Kinase is Required for Thrombospondin and Tenascin Mediated Focal Adhesion Disassembly"
  • 99. Butt E.Walter U., in 'Platelets: A Practical Approach' IRL Press Oxford, 0, 259 - 278 (1996), "Cyclic Nucleotides: Measurement and Function"
  • 100. Ückert S., Truss M. C., Stief C. G., Becker A. J.Jonas U., Jahrbuch der Urologie, 0, 0 - 0 (1996), "Beeinflussung des Tonuszustandes Porciner Detrusormuskulatur durch Modulation Intrazellulärer Schlüsselenzyme in Vitro"
  • 101. Romano A., Delorenzi A., Pedreira M. E., Tomsic D.Maldonado H., Behav. Brain Res., 75, 119 - 125 (1996), "Acute Administration of a Permeant Analog of cAMP and a Phosphodiesterase Inhibitor Improve Long-term Habituation in the Crab Chasmagnathus"
  • 102. Sirotkin A. V., Makarevich A. V.Genieser H.-G., J. Physiol. Pharmacol., 47, 134 - 0 (1996), "Effect of Regulators of Protein Kinase A on IGF-I and Steroid Secretion by Porcine Granulosa Cells in Vitro"
  • 103. Ojeda F., Folch H., Guarda M. I., Jastorff B.Diehl H. A., Biol. Chem. Hoppe-Seyler, 376, 389 - 393 (1995), "Induction of Apoptosis in Thymocytes: New Evidence for an Interaction of PKC and PKA Pathways"
  • 104. Sidhu J. S.Omiecinski C. J., J. Biol. Chem., 270, 12762 - 12773 (1995), "cAMP-associated Inhibition of Phenobarbital-inducible Cytochrome P450 Gene Expression in Primary Rat Hepatocyte Cultures"
  • 105. Ruchaud S., Zorn M., Davilar-Villar E., Genieser H.-G., Hoffmann C., Gjertsen B. T., Doeskeland S. O., Jastorff B.Lanotte M., Cell. Pharmacol., 2, 127 - 140 (1995), "Evidence for Several Pathways of Biological Response to Hydrolysable cAMP-Analogues Using a Model System of Apoptosis in IPC-81 Leukaemia Cells"
  • 106. Nakamura K., Kimura M.Aviv A., Biochem. J., 310, 263 - 269 (1995), "Role of Cyclic Nucleotides in Store-mediated External Ca2+ Entry in Human Platelets"
  • 107. Butt E., Pöhler D., Genieser H.-G., Huggins J. P.Bucher B., Br. J. Pharmacol., 116, 3110 - 3116 (1995), "Inhibition of Cyclic GMP-dependent Protein Kinase-mediated Effects by (Rp)-8-bromo-PET- cyclic GMPS"
  • 108. Genieser H.-G., Proc. 9. Int. Conf. Second Mess. & Phosphoprot. TN USA, 0, 0 - 0 (1995), "Lipophilic Ranking of Biologically Important Cyclic Nucleotides"
  • 109. Kwak B. R., Hermans M. M. P., De Jonge H. R., Lohmann S. M., Jongsma H. J.Chanson M., Mol. Biol. Cell, 6, 1707 - 1719 (1995), "Differential Regulation of Distinct Types of Gap Junction Channels by Similar Phosphorylating Conditions"
  • 110. Pöhler D., Butt E., Meißner J., Müller S., Walter U., Lohmann S. M.Jarchau T., FEBS Lett., 374, 419 - 425 (1995), "Expression, Purification, and Characterization of the cGMP-dependent Protein Kinases Iß and II Using the Baculovirus System"
  • 111. Muresan S., Bologa C., Mracec M., Chiriac A., Jastorff B., Simon Z.Naray-Szabo G., J. Mol. Struct., 342, 161 - 171 (1995), "Comparative QSAR Study with Electronic and Steric Parameters for cAMP Derivatives with Large Substituents in Positions 2, 6 and 8"
  • 112. Hell J. W., Yokoyama C. T., Breeze L. J., Chavkin C.Catterall W. A., EMBO J., 14, 3036 - 3044 (1995), "Phosphorylation of Presynaptic and Postsynaptic Calcium Channels by cAMP-Dependent Protein Kinase in Hippocampal Neurons"
  • 113. Schäfer C., Steffen H., Printz H.Göke B., Can. J. Physiol. Pharmacol., 72, 1138 - 1147 (1994), "Effects of Synthetic Cyclic AMP Analogs on Amylase Exocytosis from Rat Pancreatic Acini"
  • 114. Muresan S., Bologa C., Chiriac A., Jastorff B., Kurunczi L.Simon Z., Quant. Struct.-Act. Relat., 13, 242 - 248 (1994), "Comparative Structure-Affinity Relations by MTD for Binding of Cycloadenosine Monophosphate Derivatives to Protein Kinase Receptors"
  • 115. Butt E., Eigenthaler M.Genieser H.-G., Eur. J. Pharmacol., 269, 265 - 268 (1994), "(Rp)-8-pCPT-cGMPS, a Novel cGMP-dependent Protein Kinase Inhibitor"
  • 116. Horstrup K., Jablonka B., Hönig-Liedl P., Just M., Kochsiek K.Walter U., Eur. J. Biochem., 225, 21 - 27 (1994), "Phosphorylation of Focal Adhesion Vasodilator-stimulated Phosphoprotein at Ser 157 in Intact Human Platelets Correlates With Fibrinogen Receptor Inhibition"
  • 117. Meinecke M., Geiger J., Butt E., Sandberg M., Jahnsen T., Chakraborty T., Walter U., Jarchau T.Lohmann S. M., Mol. Pharmacol., 46, 283 - 290 (1994), "Human Cyclic GMP-dependent Protein Kinase I Overexpression Increases Phosphorylation of an Endogenous Focal Contact-associated Vasodilator-stimulated Phosphoprotein without Altering the Thrombin-evoked Calcium Response"
  • 118. Schultz C., Vajanaphanich M., Genieser H.-G., Jastorff B., Barrett K. E.Tsien R. Y., Mol. Pharmacol., 46, 702 - 708 (1994), "Membrane-permeant Derivatives of Cyclic AMP Optimized for High Potency, Prolonged Activity, or Rapid Reversibility"
  • 119. Wilkins T. J., de Ondarza J.Hootman S. R., Biochem. Biophys. Res. Commun., 205, 423 - 428 (1994), "Intracellular Mediators of Goblet Cell Degranulation in Isolated Pancreatic Ducts"
  • 120. Nolte C., Eigenthaler M., Horstrup K., Hönig-Liedl P.Walter U., Biochem. Pharmacol., 48, 1569 - 1575 (1994), "Synergistic Phosphorylation of the Focal Adhesion-Associated Vasodilator-Stimulated Phosphoprotein in Intact Human Platelets in Response to cGMP- and cAMP-Elevating Platelet Inhibitors"
  • 121. Geiger J., Nolte C.Walter U., Am. J. Physiol., 267, 236 - 244 (1994), "Regulation of Calcium Mobilization and Entry in Human Platelets by Endothelium-Derived Factors"
  • 122. Schaap P., Van Ments-Cohen M., Soede R. D. M., Brandt R., Firtel R. A., Dostmann W., Genieser H.-G., Jastorff B.Van Haastert P. J. M., J. Biol. Chem., 268, 6323 - 6331 (1993), "Cell-permeable Non-hydrolyzable cAMP Derivatives as Tools for Analysis of Signaling Pathways Controlling Gene Regulation in Dictyostelium"
  • 123. Laychock S. G., Endocrine Res., 19, 113 - 122 (1993), "Sp- 5, 6- Dichloro- 1- ß- D- ribofuranosylbenzimidazole- 3', 5'-cyclic monophosphorothioate is a Potent Stimulus for Insulin Release"
  • 124. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 125. Jastorff B., Proceeding of the 8th. Internatl. Conference on Second Messengers & Phosphoproteins UK, 0, 0 - 0 (1992), "A New Generation of Cyclic Nucleotide Analogues : Site Specific, Enzyme Selective, Agonistic or Antagonistic and Resistant to Hydrolysis"
  • 126. Genieser H.-G., Winkler E., Butt E., Zorn M., Schulz S., Iwitzki F., Störmann R., Jastorff B., Doeskeland S. O., Oegreid D., Ruchaud S.Lanotte M., Carbohydr. Res., 234, 217 - 235 (1992), "Derivates of 1-ß-D-Ribofuranosylbenzimidazole 3', 5'-phosphate that Mimic the Actions of Adenosine 3', 5',- phosphate (cAMP) and Guanosine 3', 5'- phosphate (cGMP)"
  • 127. Jastorff B., Maronde E., van Bemmelen M. X. P., Zorn M.Störmann R., Proc. 3rd Intl. Symp. Mol. Aspects Chemother. Poland, PWN Warsaw & Springer Verlag New York, 0, 57 - 87 (1991), "Cyclic Nucleotide Metabolism as a Target in Chemotherapy"
  • 128. Sandberg M., Butt E., Nolte C., Fischer L., Halbrügge M., Beltmann J., Jahnsen T., Genieser H.-G., Jastorff B.Walter U., Biochem. J., 279, 521 - 527 (1991), "Characterization of Sp- 5, 6- dichloro-1-ß-D-ribofuranosylbenzimidazole- 3',5'- monophosphorothioate (Sp-5,6-DCl-cBIMPS) as a Potent and Specific Activator of cyclic AMP- dependent Protein Kinase in Cell Extracts and Intact Cells"
  • 129. Dostmann W. R. G., Taylor S. S., Genieser H.-G., Jastorff B., Doeskeland S. O.Oegreid D., J. Biol. Chem., 265, 10484 - 10491 (1990), "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"
  • 130. Meijer L., Dostmann W., Genieser H.-G., Butt E.Jastorff B., Develop. Biol., 133, 58 - 66 (1989), "Starfish Oocyte Maturation: Evidence for a Cyclic AMP-Dependent Inhibitory Pathway"

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