0 Items - $0.00
Categories
A to Z

c-diGMP

Cyclic diguanosine monophosphate ( c-diGMP ), sodium salt
Bacterial second messenger
Cat. No.: C 057
    
CAS No.: [2222132-40-1] (sodium salt) / [61093-23-0] (free acid)
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 057-01
Unit: 1 µmol / ~0.7 mg
$125.00

For other salt forms please inquire. The metabolite pGpG (Cat. No. P 023) is available as well. Bacterial second Messenger and STING ligand. Detailed technical information and references available. References: Ross et al., Nature., 325, 279 - 281 (1987); Jenal, Curr. Opin. Microbiol., 7, 185 - 191 (2004); Simm et al., Mol. Microbiol., 53, 1123 - 1134 (2004);  Karaolis et al., Biochem. Biophys. Res. Comm., 329, 40 - 45 (2005); Méndez-Ortiz et al., J. Biol. Chem., 281, 8090 - 8099 (2006); Lee et al., Science, 329, 845 - 848 (2010).

Cat. No. C 057
CAS number [2222132-40-1] (sodium salt) / [61093-23-0] (free acid)
Purity > 98% HPLC (typically > 99%)
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₄P₂ (free acid)
Molecular weight [g/mol] 690.4 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23700
  • 1. Li W., Cui T., Hu L., Wang Z., Li Z.He Z.-G., Nature Communications, 0, 0 - 0 (2015), "Cyclic Diguanylate Monophosphate Directly Binds to Human Siderocalin and Inhibits its Antibacterial Activity"
  • 2. Shi H., Wu J., Chen Z. J.Chen C., Proc. Natl. Acad. Sci. USA, 112, 8947 - 8952 (2015), "Molecular Basis for the Specific Recognition of the Metazoan Cyclic GMP-AMP by the Innate Immune Adaptor Protein STING"
  • 3. Gundlach J., Dickmanns A., Schröder-Tittmann K., Neumann P., Kaesler J., Kampf J., Herzberg C., Hammer E., Schwede F., Kaever V., Tittmann K., Stülke J.Ficner R., J.Biol.Chem., 290, 3069 - 3080 (2015), "Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding PII-like Signal Transduction Protein DarA"
  • 4. Hanson M. C., Crespo M. P., Abraham W., Moynihan K. D., Szeto G. L., Chen S. H., Melo M. B., Mueller S.Irvine D. J., J.Clin.Invest., 125, 2532 - 2546 (2015), "Nanoparticulate STING Agonists are Potent Lymph Node-targeted Vaccine Adjuvants"
  • 5. Gaffney B. L.Jones R. A., Org. Lett., 16, 158 - 161 (2014), "Synthesis of c-di-GMP Analogs with Thiourea, Urea, Carbodiimide, and Guanidinium Linkages"
  • 6. Sundriyal A. S., Massa C., Samoray D., Zehender F., Sharpe T., Jenal U.Schirmer T., J. Biol. Chem., 289, 6978 - 6990 (2014), "Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP"
  • 7. Blaauboer S. M., Gabrielle V. D.Jin L., J. Immunol., 192, 492 - 502 (2014), "MPYS/STING-Mediated TNF-alpha, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3´–5´)-Cyclic-Di-Guanosine-Monophosphate In Vivo"
  • 8. Lolicato M., Bucchi A., Arrigoni C., Zucca S., Nardini M., Schroeder I., Simmons K., Aquila M., DiFrancesco D., Bolognesi M., Schwede F., Kashin D., Fishwick C. W. G., Johnson A. P., Thiel G.Moroni A., Nat. Chem. Biol., 10, 457 - 462 (2014), "Cyclic Dinucleotides bind the C-linker of HCN4 to Control Channel cAMP Responsiveness"
  • 9. Sureka K., Choi P. H., Precit M., Delince M., Pensinger D. A., Huynh T. N., Jurado A. R., Goo Y. A., Sadilek M., Iavarone A. T., Sauer J. D., Tong L.Woodward J. J., Cell, 158, 1389 - 1401 (2014), "The Cyclic Dinucleotide c-diAMP is an Allosteric Regulator of Metabolic Enzyme Function"
  • 10. Wu J., Sun L., Chen X., Du F., Shi H., Chen C.Chen Z. J., Science, 339, 826 - 830 (2013), "Cyclic GMP-AMP is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA"
  • 11. Ablasser A., Goldeck M., Cavlar T., Deimling T., Witte G., Röhl I., Hopfner K.-P., Ludwig J.Hornung V., Nature, 498, 380 - 384 (2013), "cGAS Produces a 2'-5'-Linked Cyclic Dinucleotide Second Messenger that Activates STING"
  • 12. Sun L., Wu J., Du F., Chen X.Chen Z. J., Science, 339, 786 - 791 (2013), "Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway"
  • 13. Corrigan R. M., Campeotto I., Jeganathan T., Roelofs K. G., Lee V. T.Gründling A., Proc. Natl. Acad. Sci. USA, 110, 9084 - 9089 (2013), "Systematic Identification of Conserved Bacterial c-di-AMP Receptor Proteins"
  • 14. Ablasser A., Schmid-Burgk J. L., Hemmerling I., Horvath G. L., Schmidt T., Latz E.Hornung V., Nature, 503, 530 - 534 (2013), "Cell Intrinsic Immunity Spreads to Bystander Cells via the Intercellular Transfer of cGAMP"
  • 15. Stelitano V., Giardina G., Paiardini A., Castiglione N., Cutruzzola F.Rinaldo S., PLoS ONE, 8, 0 - 0 (2013), "C-diGMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG"
  • 16. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., Biochemistry, 52, 365 - 377 (2013), "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase"
  • 17. Schaap P., IUBMB Life, 65, 65, 897 - 903 (2013), "Cyclic di-Nucleotide Signaling Enters the Eukaryote Domain"
  • 18. Yi G., Brendel V. P., Shu C., Li P., Palanathan S.Kao C. C., PLoS One., 8(10), 0, 0 - 0 (2013), "Single Nucleotide Polymorphisms of Human STING Can affect Innate Immune Response to Cyclic Dinucleotides"
  • 19. Mehne F. M. P., Gunka K., Eilers H., Herzberg C., Kaever V.Stülke J., J. Biol. Chem., 288, 2004 - 2017 (2013), "Cyclic Di-AMP Homeostasis in Bacillus subtilis: Both Lack and High Level Accumulation of the Nucleotide Are Detrimental for Cell Growth"
  • 20. Abdul-Sater A. A., Tattoli I., Jin L., Grajkowski A., Levi A., Koller B. H., Allen I. C., Beaucage S. L., Fitzgerald K. A., Ting J. P.-Y., Cambier J. C., Girardin S. E.Schindler C., EMBO Rep., 14, 900 - 906 (2013), "Cyclic-di-GMP and Cyclic-di-AMP Activate the NLRP3 Inflammasome"
  • 21. Dubensky T. W., Kanne D. B.Leong M. L., Ther. Adv. Vaccines, 1, 131 - 143 (2013), "Rationale, Progress and Development of Vaccines Utilizing STING-activating Cyclic Dinucleotide Adjuvants"
  • 22. Gao X., Mukherjee S., Matthews P. M., Hammad L. A., Kearns D. B.Dann C. E., J. Bacteriol., 195, 4782 - 4792 (2013), "Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway"
  • 23. Kim S., Li L., Maliga Z., Yin Q., Wu H.Mitchison T. J., ACS Chem. Biol., 8, 1396 - 1401 (2013), "Anti-cancer Flavonids are Mouse Selective STING Agonists"
  • 24. Abdul-Sater A. A., Grajkowski A., Erdjument-Bromage H., Plumlee C., Levi A., Schreiber M. T., Lee C., Shuman H., Beaucage S. L.Schindler C., Microbes Infect., 14, 188 - 197 (2012), "The Overlapping Host Reponses to Bacterial Cyclic Dinucleotides"
  • 25. Düvel J., Bertinetti D., Möller S., Schwede F., Morr M., Wissing J., Radamm L., Zimmermann B., Genieser H.-G., Jänsch L., Herberg F. W.Häussler S., J. Microbiol. Methods., 88, 229 - 236 (2012), "A Chemical Proteomics Approach to Identify c-di-GMP Binding Proteins in Pseudomonas Aeruginosa"
  • 26. Chen Z.-H.Schaap P., Nature, 488, 680 - 683 (2012), "The Prokaryote Messenger c-di-GMP Triggers Stalk Cell Differentiation in Dictyostelium"
  • 27. Davies B. W., Bogard R. W., Young T. S.Mekalanos J. J., Cell, 149, 358 - 370 (2012), "Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. Cholerae Virulence"
  • 28. Sharma I. M., Dhanaraman T., Mathew R.Chatterji D., Biochemistry, 51, 5443 - 5453 (2012), "Synthesis and Characterization of a Fluorescent Analogue of Cyclic Di-GMP"
  • 29. Gentner M., Allan M. G., Zaehringer F., Schirmer T.Grzesiek S., J. Am. Chem. Soc., 134, 1019 - 1029 (2012), "Oligomer Formation of the Bacterial Second Messenger c-di-GMP: Reaction Rates and Equilibrium Constants Indicate a Monomeric State at Physiological Concentrations"
  • 30. Furukawa K., Gu H., Sudarsan N., Hayakawa Y., Hyodo M.Breaker R. R., ACS Chem Biol., 17, 14369 - 1443 (2012), "Identification of Ligand Analogues that Control c-di-GMP Riboswitches"
  • 31. Bobrov A. G., Kirillina O., Ryjenkov D. A., Waters C. M., Price P. A., Fetherston J. D., Mack D., Goldman W. E., Gomelsky M.Perry R. D., Molecular Microbiology, 79, 533 - 551 (2011), "Systematic Analysis of Cyclic Di-GMP Signalling Enzymes and Their Role in Biofilm Formation and Virulence in Yersinia Pestis"
  • 32. Ebensen T., Libanova R., Schulze K., Yevsa T., Morr M.Guzman C. A., Vaccine, 29, 5210 - 5220 (2011), "Bis-(3',5')-cyclic Dimeric Adenosine Monophosphate: Strong Th1/Th2/Th17 Promoting Mucosal Adjuvant"
  • 33. Spangler C., Kaever V.Seifert R., J. Pharmacol. Exp. Ther., 336, 234 - 241 (2011), "Interaction of the Diguanylate Cyclase YdeH of Escheria Coli with 2´,(3´)-Substituted Purine and Pyrimidine Nucleotides"
  • 34. Zhang L. X.Meuwly M., Chemphyschem., 12, 295 - 302 (2011), "Stability and Dynamics of Cyclic Diguanylic Acid in Solution"
  • 35. Shin J. S., Ryu K. S., Ko J., Lee A.Choi B. S., Protein Sci., 20, 270 - 277 (2011), "Structural Characterization Reveals That a PilZ Domain Protein Undergoes Substantial Conformational Change Upon Binding to Cyclic Dimeric Guanosine Monophosphate"
  • 36. Newell P. D., Boyd C. D., Sondermann H.O´Toole G. A., PLoS Biol., 9, 0 - 0 (2011), "A c-Di-GMP Effector System Controls Cell Adhesion by Inside-Out Signaling and Surface Protein Cleavage"
  • 37. Navarro M. V. A. S., Newell P. D., Krasteva P. V., Chatterjee D., Madden D. R., O´Toole G. A.Sondermann H., PLoS Biol., 9, 0 - 0 (2011), "Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis"
  • 38. Gomelsky M., Mol. Microbiol., 79, 562 - 565 (2011), "cAMP, c-di-GMP, c-di-AMP and now cGMP: Bacteria use Them All!"
  • 39. Smith K. D., Shanahan C. A., Moore E. L., Simon A. C.Strobel S. A., Proc. Natl. Acad. Sci. USA, 108, 7757 - 7762 (2011), "Structural Basis of Differential Ligand Recognition by Two Classes of bis-(3'-5')-cyclic Dimeric Guanosine Monophosphate-binding Riboswitches"
  • 40. Oppenheimer-Shaanan Y., Wexselblatt E., Katzhendler J., Yavin E.Ben-Yehuda S., EMBO Rep., 12, 594 - 601 (2011), "c-di-AMP Reports DNA Integrity During Sporulation in Bacillus subtilis"
  • 41. Smith K. D.Strobel S. A., Biochem. Soc. Trans., 39, 647 - 651 (2011), "Interactions of the c-di-GMP Riboswitch with its Second Messenger Ligand"
  • 42. Kostick J., Szkotnicki L. T., Rogers E. A., Bocci P., Raffaelli N.Marconi R. T., Mol. Microbiol., 81, 219 - 231 (2011), "The Diguanylate Cyclase, Rrp1, Regulates Critical Steps in the Enzootic Cycle of the Lyme Disease Spirochetes"
  • 43. Wang J. X., Zhou J., Donaldson G. P., Nakayama S., Yan L., Lam Y. F., Lee V. T.Sintim H. O., J. Am. Chem. Soc., 133, 9320 - 9330 (2011), "Conservative Change to the Phosphate Moiety of Cyclic Diguanylic Monophosphate Remarkably Affects Its Polymorphism and Ability to Bind DGC, PDE, and Pilz Proteins"
  • 44. Johnson J. G., Murphy C. N., Sippy J., Johnson T. J.Clegg S., J. Bacteriol., 193, 3453 - 3460 (2011), "Type 3 Fimbriae and Biofilm Formation are Regulated by the Transcriptional Regulators MrkHI in Klebsiella Pneumoniae"
  • 45. He M., Ouyang Z. M., Troxell B., Xu H. J., Moh A., Piesman J., Norgard M. V., Gomelsky M.Yang X. F., PLAS Pathogens, 7, 0 - 0 (2011), "Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks"
  • 46. Matilla M. A., Travieso M. L., Ramos J. L.Ramos-Gonzales M. I., Environmental Microbiol., 13, 1745 - 1766 (2011), "Cyclic Diguanylate Turnover Mediated by the Sole GGDEF/EAL Response Regulator in Pseudomonas putida: its Role in the Rhizosphere and an Analysis of its Target Processes"
  • 47. Pasunooti S., Surya W., Tan S. N.Liang Z.-X., Journal of Molecular Catalysis B: Enzymatic 67, 67, 98 - 103 (2010), "Sol-Gel Immobilization of a Thermophilic Diguanylate Cyclase for Enzymatic Production of Cyclic-Di-GMP"
  • 48. Harmsen M., Yang L., Pamp S. J.Tolker-Nielsen T., FEMS Immunol. Med. Microbiol., 59, 253 - 268 (2010), "An Update on Pseudomonas Aeruginosa Biofilm Formation, Tolerance, and Dispersal"
  • 49. Spangler C., Böhm A., Jenal U., Seifert R.Kaever V., J. Microbiol. Methods, 81, 226 - 231 (2010), "A Liquid Chromatography-coupled Tandem Mass Spectrometry Method for Quantitation of Cyclic Di-guanosine Monophosphate"
  • 50. Malone J. G., Jaeger T., Spangler C., Ritz D., Spang A., Arrieumerlou C., Kaever V., Landmann R.Jenal U., PLOS Pathogenes, 6, 1 - 17 (2010), "YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistance in Pseudomonas Aeruginosa"
  • 51. Liu X. X., Beyhan S., Lim B., Linnington R. G.Yildiz F. H., J.Bacteriol., 192, 4541 - 4552 (2010), "Identification and Characterization of a Phosphodiesterase that Inversely Regulates Motility and Biofilm Formation in Vibrio Cholarae"
  • 52. Tagliabue L., Maciag A., Antoniani D.Landini P., FEMS Immunol. Med. Microbiol., 59, 477 - 484 (2010), "The yddV-dos Operon Controls Biofilm Formation through the Regulation of Genes Encoding Curli Fibers' Subunits in Aerobically Growing Escherichia Coli"
  • 53. Sintim H. O., Al Smith J. A., Wang J. X., Nakayama S.Yan L., Future Medicinal Chemistry, 2, 1005 - 1035 (2010), "Paradigm Shift in Discovering Next-generation Anti-infective Agents: Targeting Quorum Sensing, c-diGMP Signaling and Biofilm Formation in Bacteria with Small Molecules"
  • 54. Ching S. M., Tan W. J., Chua K. L.Lam Y., Bioorg. Med. Chem., 18, 6657 - 6665 (2010), "Synthesis of Cyclic Di-nucleotidic Acid as Potential Inhibitors Targeting Diguanylate Cyclase"
  • 55. Tchigvintsev A., Xu X., Singer A., Chang C., Brown G., Proudfoott M., Cui H., Flick R., Anderson W. F., Joachimiak A., Galperin M. Y., Savchenko A.Yakunin A. F., J. Mol. Biol., 402, 524 - 538 (2010), "Structural Insight into the Mechanism of c-Di-GMP Hydrolysis by EAL Domain Phosphodiesterases"
  • 56. Chen W. X., Patel G. B., Yan H. B.Zhang J. B., Hum. Vaccin., 6, 706 - 714 (2010), "Recent Advances in the Development of Novel Mucosal Adjuvants and Antigen Delivery Systems"
  • 57. Tagliabue L., Antoniani D., Maciag A., Bocci P., Raffaelli N.Landini P., Microbiology, 156, 2901 - 2911 (2010), "The Diguanylate Cyclase YddV Controls Production of the Exopolysaccharide Poly-N-Acetylglucosamine (PNAG) through Regulation of the PNAG Bionsynthetic pgaABCD Operon"
  • 58. Gerlo S., Verdood P.Kooijman R., J. Interferon Cytokine Res., 30, 883 - 891 (2010), "Modulation of Cytokine Production by Cyclic Adenosine Monophosphate Analogs in Human Leukocytes"
  • 59. Kanazawa T., Ren S., Maekawa M., Hasegawa K., Arisaka F., Hyodo M., Hayakawa Y., Ohta H.Masuda S., Biochemistry, 49, 10647 - 10655 (2010), "Biochemical and Physiological Characterization of a BLUF Protein-EAL Preotein Complex Involved in Blue Light-Dependent Degradation of Cyclic Diguanylate in the Purple Bacterium Rhodopseudomonas Palustris"
  • 60. Zahringer F., Massa C.Schirmer T., Appl. Biochem. Biotechnol., 163, 71 - 79 (2010), "Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase Ydeh from E. Coli"
  • 61. Kitanishi K., Kobayashi K., Kawamura Y., Ishigami I., Ogura T., Nakajima K., Igarashi J., Tanaka A.Shimizu T., Biochemistry, 49, 10381 - 10393 (2010), "Important Roles of Tyr43 at the Putative Heme Distal Side in the Oxygen Recognition and Stability of the Fe(II)-O2 Complex of YddV, a Globin-Coupled Heme-Based Oxygen Sensor Diguanylate Cyclase"
  • 62. Rao F., See R. Y., Zhang D., Toh D. C., Ji Q.Liang Z.-X., J. Biol. Chem., 285, 473 - 482 (2010), "YybT is a Signaling Protein that Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity"
  • 63. Chen W., KuoLee R.Yan H., Vaccine, 28, 3080 - 3085 (2010), "The Potential of 3'-5'-cyclic Digunanylic Acid (c-di-GMP) as an Effective Vaccine Adjuvant"
  • 64. Libanova R., Ebensen T., Schulze K., Bruhn D., Nörder M., Yevsa T., Morr M.Guzman C. A., Vaccine, 28, 2249 - 2258 (2010), "The Member of the cyclic Di-Nucleotide Family bis-(3', 5')-cyclic Dimeric Inosine Monophosphate Exerts Potent Activity as Mucosal Adjuvant"
  • 65. Lee E. R., Baker J. L., Weinberg Z., Sudarsan N.Breaker R. R., Science, 329, 845 - 848 (2010), "An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger"
  • 66. Boehm A., Kaiser M., Li H., Spangler C., Kasper C. A., Ackermann M., Kaever V., Sourjik V., Roth V.Jenal U., Cell, 141, 107 - 116 (2010), "Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity"
  • 67. Jonas K., Melefors Ö., Römling U., Gosselin G., Imbach J.-L.Perigaud C., Future Microbiol., 4, 341 - 358 (2009), "Regulation of c-di-GMP metabolism in Biofilms"
  • 68. Rao F., Pasunooti S., Ng Y., Zhuo W., Lim L., Liu A. W.Liang Z.-X., Anal. Biochem., 389, 138 - 142 (2009), "Enzymatic Synthesis of c-di-GMP Using a Thermophilic Diguanylate Cyclase"
  • 69. Hu D. L., Narita K., Hyodo M., Hayakawa Y., Nakane A.Karaolis D. K. R., Vaccine, 27, 4867 - 4873 (2009), "C-di-GMP as a Vaccine Adjuvant Enhances Protection Against Systemic Methicillin-resistant Staphylococcus Aureus (MRSA) Infection"
  • 70. Hengge R., Nat. Rev. Microbiol., 7, 263 - 273 (2009), "Principles of c-di-GMO Signalling in Bacteria"
  • 71. Lai T.-H., Kumagai Y., Hyodo M., Hayakawa Y.Rikihisa Y., J Bacteriol., 191, 693 - 700 (2009), "The Anaplasma Phagocytophilum PleC Histidine Kinase and PleD Diguanylate Cyclase Two-Component System and Role of Cyclic Di-GMP in Host Cell Infection"
  • 72. Pesavento C.Hengge R., Curr. Opin. Microbiol., 12, 170 - 176 (2009), "Bacterial Nucleotide-based Second Messengers"
  • 73. Kline T., Jackson S. R., Deng W., Verlinde C. L. M. J.Miller S. I., Nucleos. Nucleot. Nucleic Acids, 27, 1282 - 1300 (2008), "Design and Synthesis of bis-carbamate Analogs of cyclic bis-(3'-5')-diguanylic Acid (c-di-GMP) and the Acyclic Dimer PGPG"
  • 74. Yan H., Wang X., KuoLee R.Chen W., Bioorg. Med. Chem. Lett., 18, 5631 - 5634 (2008), "Synthesis and Immunostimulatory Properties of the Phosphorothioate Analogues of c-di-GMP"
  • 75. Waters C. A., Lu W. Y., Rabinowitz J. D.Bassler B. L., J. Bacteriol., 190, 2527 - 2536 (2008), "Quorum Sensing Controls Biofilm Formation in Vibrio Cholerae through Modulation of cyclic-di-GMP Levels and Repression of vpsT"
  • 76. De N., Pirrucello M., Krasteva P. V., Bae N., Raghavan R. V.Sondermann H., PLoS Biology, 6, 601 - 617 (2008), "Phosphorylation-independent Regulation of the Diguanylate Cyclase WspR"
  • 77. Sudarsan N., Lee E. R., Weinberg Z., Moy R. H., Kim J. N., Link K. H.Breaker R. R., Science, 321, 411 - 413 (2008), "Riboswitches in Eubacteria Sense the Second Messenger cyclic di-GMP"
  • 78. Tanaka A.Shimizu T., Biochemistry, 47, 13438 - 13446 (2008), "Ligand Binding to the Fe(III)-Protoporphyrin IX complex of Phosphodiesterase from Escherichia coli (Ec DOS) Markedly Enhances Catalysis of Cyclic di-GMP: Roles of Met95, Arg97, and Phe113 of the Putative Heme Distal Side in Catalytic Regulation and Ligand Binding"
  • 79. Yan H.Aguilar A. L., Nucleos. Nucleot. Nucleic Acids, 26, 189 - 204 (2007), "Synthesis of 3',5'-cyclic Diguanylic Acid (cdiGMP) Using 1-(4-Ethoxypiperidin-4YL as a Protecting Group for 2'-Hydroxy Functions of Ribonucleosides"
  • 80. Guvener Z. T., Harwood C. S.Herberg F. W., Mol. Microbiol., 66, 1459 - 1473 (2007), "Subcellular Location Characteristics of the Pseudomonas Aeruginosa GGDEF Protein, WspR, Indicate that it Produces cyclic-diGMP in Response to Growth on Surfaces"
  • 81. Simm R., Ph.D. Thesis, Karolinska Institute, Stockholm, Sweden, 0, 1 - 40 (2007), "Characterization of c-diGMP Signalling in Salmonella Typhimurium"
  • 82. Monds R. D., Newell P. D., Gross R. H.O'Toole G. A., Mol. Microbiol., 63, 656 - 679 (2007), "Phosphate-dependent Modulation of c-di-GMP Levels Regulates Fluorescence Pf0-1 Biofilm Formation by Controlling Secretion of the Adhesin LapA"
  • 83. Karaolis D. K. R., Means T. K., Yang D., Takahashi M., Yoshimura T., Muraille E., Philpott D., Schroeder J. T., Hyodo M., Hayakawa Y., Talbot B. G., Brouilette E.Malouin F., J. Immunol., 178, 2171 - 2181 (2007), "Bacterial c-di-GMP Is an Immunostimulatory Molecule"
  • 84. Kim Y.-K.McCarter L. L., J. Bacteriol., 189, 4094 - 4107 (2007), "ScrG, a GGDEF-EAL Protein, Participates in Regulating Swarming and Sticking in Vibro parahaemolyticus"
  • 85. Cotter P. A.Stibitz S., Curr. Opin. Microbiol., 10, 17 - 23 (2007), "C-di-GMP Mediated Regulation of Virulence and Biofilm Formation"
  • 86. Simm R., Lusch A., Kader A., Andersson M.Römling U., J. Bacteriol., 189, 3613 - 3623 (2007), "Role of EAL-containing Proteins in Multicellular Behavior of Salmonella enterica Serovar Typhimurium"
  • 87. Tanaka A., Takahashi H.Shimizu T., J. Biol. Chem., 282, 21301 - 21307 (2007), "Critical Role of the Heme Axial Ligand, Met95, in Locking Catalysis of the Phosphodiesterase from Escherichia coli (Ec DOS) toward Cyclic diGMP"
  • 88. Christen M., Christen B., Allan G. M., Folcher M., Jenoe P., Grzesiek S.Jenal U., Proc. Natl. Acad. Sci. USA, 104, 4112 - 4117 (2007), "DgrA is a Member of a New Family of Cyclic Diguanosine Monophosphate Receptors and Controls Flagellar Motor Function in Caulobacter Crescentus"
  • 89. Römling U., BIOspektrum, 20, 134 - 136 (2007), "C-di-GMP - ein neuer sekundärer Botenstoff in Bakterien"
  • 90. Hyodo M., Sato Y.Hayakawa Y., Tetrahedron, 62, 3089 - 3094 (2006), "Synthesis of cyclic bis(3',5')diguanylic Acid (c-di-GMP) Analogs"
  • 91. Mendez-Ortiz M. M., Hyodo M., Hayakawa Y.Membrillo-Hernandez J., J. Biol. Chem., 281, 8090 - 8099 (2006), "Genome-wide Transcriptional Profile of Escherichia coli in Response to High Levels of the Second Messenger 3', 5'- cyclic Diguanylic Acid"
  • 92. Zhang Z., Kim S., Gaffney B. L.Jones R. A., J. Am. Chem. Soc., 128, 7015 - 7024 (2006), "Polymorphism of the Signaling Molecule c-di-GMP"
  • 93. Gjermansen M., Ragas P.Tolker-Nielsen T., FEMS Microbiol. Lett., 265, 215 - 224 (2006), "Proteins with GGDEF and EAL Domains Regulate Pseudomonas Putida Biofilm Formation and Dispersal"
  • 94. Takahashi H.Shimizu T., Chem. Lett., 35, 970 - 971 (2006), "Phosphodiesterase Activity of Ec DOS, a Heme-regulated Enzyme from Escherichia coli, Toward 3',5'-cyclic Diguanylic Acid is Obviously Enhanced by O-2 and CO Binding"
  • 95. Ryan R. P., Fouhy Y., Lucey J. F.Dow J. M., J. Bacteriol., 188, 8327 - 8334 (2006), "Cyclic Di-GMP Signaling in Bacteria: Recent Advances and New Puzzles"
  • 96. Christen B., Christen M., Paul R., Schmid F., Folcher M., Jenoe P., Meuwly M.Jenal U., J. Biol. Chem., 281, 32015 - 32024 (2006), "Allosteric Control of Cyclic di-GMP Signaling"
  • 97. Jenal U.Malone J., Annu. Rev. Genet., 40, 385 - 407 (2006), "Mechanism of Cyclic-di-GMP Signaling in Bacteria"
  • 98. Beyhan S., Tischler A. D., Camilli A.Yildiz F. H., J. Bacteriol., 88, 3600 - 3613 (2006), "Transcriptome and Phenotypic Responses of Vibrio cholerae to Increased Cyclic di-GMP Level"
  • 99. Hyodo M., Sato Y., Hayakawa Y.Karaolis D. K. R., Nucleic Acids Symposium Series, 49, 117 - 118 (2005), "Chemical Behavior of bis(3'-5')diguanylic Acid in Aqueous Solutions"
  • 100. Karaolis D. K. R., Cheng K., Lipsky M., Elnabawi A., Catalano J., Hyodo M., Hayakawa Y.Raufmann J.-P., Biochem. Biophys. Res. Commun., 329, 40 - 45 (2005), "3',5'-Cyclic Diguanylic Acid (c-di-GMP) Inhibits Basal and Growth Factor-stimulated Human Colon Cancer Cell Proliferation"
  • 101. Tamayo R., Tischler A. D.Camilli A., J. Biol. Chem., 280, 33324 - 33330 (2005), "The Eal Protein Viea is a Cyclic Diguanylate Phosphodiesterase"
  • 102. Karaolis D. K. R., Rashid M. H., Chythanya R., Luo W., Hyodo M.Hayakawa Y., Antimicrob. Agents Chemother., 49, 1029 - 1038 (2005), "c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus Aureus Cell-Cell Interactions and Biofilm Formation"
  • 103. Hoffmann L. R., D'Argenio D. A., MacCoss M. J., Zhang Z., Jones R. A.Miller S. I., Nature, 436, 1171 - 1175 (2005), "Aminoglycoside Antibiotics Induce Bacterial Biofilm Formation"
  • 104. O'Toole G. A.Stewart P. S., Nature Biotechnol., 23, 1378 - 1379 (2005), "Biofilms Strike Back"
  • 105. Römling U., Gomelsky M.Galperin M. Y., Mol. Microbiol., 57, 629 - 639 (2005), "C-di-GMP: the Dawning of a Novel Bacterial Signalling System"
  • 106. Johnson M. R., Montero C. I., Conners S. B., Shockley K. R., Bridger S. L.Kelly R. M., Mol. Microbiol., 55, 664 - 674 (2005), "Population Density-dependent Regulation of Exopolysaccaride Formation in the Hyperthermophilic Bacterium Thermotoga Maritima"
  • 107. Brouillette E., Hyodo M., Hayakawa Y., Karaolis D. K. R.Malouin F., Antimicrob. Agents Chemother., 49, 3109 - 3113 (2005), "3´-5´-cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Stapylococcus aureus Strains in a Mouse Model of Mastitis Infection"
  • 108. Christen M., Christen B., Folcher M., Schauerte A.Jenal U., J. Biol. Chem., 280, 30829 - 30837 (2005), "Identification and Characterization of a Cyclic di-GMP-specific Phosphodiesterase and Its Allosteric Control by GTP"
  • 109. D'Argenio D. A.Miller S. I., Microbiology, 150, 2497 - 2502 (2004), "Cyclic di-GMP as a bacterial second messenger"
  • 110. Jenal U., Current Opinion in Microbiology, 7, 185 - 191 (2004), "Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?"
  • 111. Simm R., Morr M., Kader A., Nimtz M.Römling U., Mol. Microbiol., 53, 1123 - 1134 (2004), "CGDEF and EAL Domains Inversely Regulate Cyclic di-GMP Levels and Transition from Sessility to Motility"
  • 112. Chan C., Paul R., Samoray D., Amiot N. C., Giese B., Jenal U.Schirmer T., Proc. Nat. Acad. Sci. U.S.A., 101, 17084 - 17089 (2004), "Structural Basis of Activity and Allosteric Control of Diguanylate Cyclase"
  • 113. Paul R., Weiser S., Amiot N. C., Chan C., Schirmer T., Giese B.Jenal U., Gene. Develop., 18, 715 - 727 (2004), "Cell Cycle-dependent Dynamic Localization of a Bacterial Response Regulator with a Novel di-guanylate Cyclase Output Domain"
  • 114. Zhang Z., Gaffney B. L.Jones R. A., J. Am. Chem. Soc., 126, 16700 - 16701 (2004), "C-di-GMP Displays a Monovalent Metal Ion-Dependent Polymorphism"
  • 115. Amikam D., Steinberger O., Lapidot Z.Ben-Ishai Z., Cancer Detection and Prevention (CDP) Online 2000 Symposium on Cell Cycle Inhibitors Abstract 114, 0, 0 - 0 (2000), "The Novel Cyclic Dinucleotide 3' -5' Cyclic Diguanylic Acids Binds to p21ras, Induces the Expression of the CD 4 Receptor and Causes Cell Cycle Arrest in Lymphohemopoietic Cell Lines"
  • 116. Ross P., Mayer R.Benziman M., Microbiol. Rev., 55, 35 - 58 (1991), "Cellulose Biosynthesis and Function in Bacteria"
  • 117. Ross P., Mayer R., Weinhouse H., Amikam D., Huggirat Y., Benziman M., de Vroom E., Fidder A., de Paus P., Sliedregt L. A. J. M., van der Marel G. A.van Boom J. H., J. Biol. Chem., 265, 18933 - 18943 (1990), "The Cyclic Diguanylic Acid Regulatory System of Cellulose Synthesis in Acetobacter xylinum. Chemical Synthesis and Biological Activity of a Nucleotide Dimer, Trimer, and Phosphothioate Derivatives"
  • 118. Ross P., Mayer R., Weinhouse H., Amikan D., Huggirat Y., Benziman M., de Vroom E., Fidder A., de Paus P., Sliedregt L. A. J. M., van der Marel G. A.van Boom J. H., J. Biol. Chem., 265, 18933 - 18943 (1990), "The Cyclic Diguanylic Acid Regulatory System of Cellulose Synthesis in Acetobacter xylinum"
  • 119. Egli M., Gessner R. V., Williams L. D., Quigley G. J., van der Marel G. A., van Boom J. H., Rich A.Frederick C. A., Proc. Natl. Acad. Sci. USA, 87, 3235 - 3239 (1990), "Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid"
  • 120. Amikam D.Benziman M., J. Bacteriol., 171, 6649 - 6655 (1989), "Cyclic Diguanylic Acid and Cellulose Synthesis in Agrobacterium Tumefaciens"
  • 121. Ross P., Weinhouse H., Aloni Y., Michaeli D., Weinberger-Ohana P., Mayer R., Braun S., de Vroom E., van der Marel G. A., van Boom J. H.Benziman M., Nature, 325, 279 - 281 (1987), "Regulation of Cellulose Synthesis in Acetobacter Xylinum by Cyclic Diguanylic Acid"

Show more