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Alternative structural projections:

6-Bnz-cAMP

N⁶- Benzoyladenosine- 3', 5'- cyclic monophosphate ( 6-Bnz-cAMP ), sodium salt
Membrane-permeant, site-selective PKA agonist
Cat. No.: B 009
    
CAS No.: [30275-80-0]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: B 009-10
Unit: 10 µmol / ~4.6 mg
$129.00

For other salt forms or metabolites of 6-Bnz-cAMP please inquire. Site-selective and membrane-permeant activator of cAMP-dependent protein kinase (cAK) which does not activate Epac and thus can be used as an Epac-negative control. Increased metabolic stability against PDE compared to cAMP. Selects site A of both cAK isozymes and thus can be used for synergistic activation of type II when combined with site B II- selective analogues such as Sp-8-CPT-cAMPS (Cat. No. C 012) or 8-PIP-cAMP (Cat. No. P 002). For preferential stimulation of cAK type I a combination with the site B I-selective analogue 2-Cl-8-MA-cAMP (Cat. No. C 080) or 8-HA-cAMP (Cat. No. H 006) can be used. For more details on site selectivity please inquire. Detailed technical information and updated reference list available. References: Christensen et al., J. Biol. Chem., 278, 35394 - 35402 (2003); Bos, Trends Biochem. Sci., 31, 680 - 686 (2006).

Cat. No. B 009
CAS number [30275-80-0]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₁₅N₅O₇P · Na
Molecular weight [g/mol] 455.3
Target PKA (cAK) Activator
Lipophilicity 1.90
Absorption max [nm] 279
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 19700
  • 1. Schwede F., Bertinetti D., Langerijs C. N., Hadders M. A., Wienk H., Ellenbroek J. H., de Koning E. J. P., Bos J. L., Herberg F. W., Genieser H.-G., Janssen R. A.Rehmann H., PLoS Biol., 13, 1 - 26 (2015), "Structure-Guided Design of Selective Epac1 and Epac2 Agonists"
  • 2. Gausdal G., Wergeland A., Skavland J., Nguyen E., Pendino F., Rouhee N., McCormack E., Herfindal L., Kleppe R., Havemann U., Schwede F., Bruseud O., Gjertsen B. T., Lanotte M., Segal-Bendirdjian E.Doskeland S. O., Cell Death Dis., 4, 0 - 0 (2013), "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
  • 3. Lee T.-M., Lin S.-Z.Chang N.-C., PLoS ONE, 8, 0 - 0 (2013), "Both PKA and Epac Pathways Mediate N-Acetylcystine-Induced Connexin43 Preservation in Rats with Myocardial Infarction"
  • 4. Chepurny O. G., Bertinetti D., Diskar M., Leech C. A., Afshari P., Tsalkova T., Cheng X., Schwede F., Genieser H.-G., Herberg F. W.Holz G. G., Mol. Endocrinol., 27, 1267 - 1282 (2013), "Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag"
  • 5. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 6. Menon J., Doebele R. C., Gomes S., Bevilacqua E., Reindl K. M.Rosner M. R., PLoS One, e49893, 7, 0 - 0 (2012), "A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer"
  • 7. Roscioni S. S., Prins A. G., Elzinga C. R. S., Menzen M. H., Dekkers B. G. J., Halayko A. J., Meurs H., Maarsingh H.Schmidt M., Br. J. Pharmacol., 164, 958 - 969 (2011), "Protein Kinase A and the Exchange Protein Directly Activated by cAMP (EPAC) Modulate Phenotype Plasticity in Human Airway Smooth Muscle"
  • 8. Zieba B. J., Artamonov M. V., Jin L., Momotani K., Ho R., Franke A. S., Neppl R. L., Stevenson A. S., Khromov A. S., Chrzanowska-Wodnicka M.Somlyo A. V., J. Biol.Chem., 286, 16681 - 16692 (2011), "The cAMP-Responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity"
  • 9. Roscioni S. S., Maarsingh H., Elzinga C. R. S., Schuur J., Menzen M., Halayko A. J., Meurs H.Schmidt M., J. Cell. Mol. Med., 15, 1551 - 1563 (2011), "Epac as a Novel Effector of Airway Smooth Muscle Relaxation"
  • 10. Werner K., Schwede F., Genieser H.-G., Geiger J.Butt E., Naunyn Schmiedebergs Arch. Pharmacol., 384, 169 - 176 (2011), "Quantification of cAMP and cGMP Analogs in Intact Cells: Pitfalls in Enzyme Immunoassays for Cyclic Nucleotides"
  • 11. Liu H., Enyeart J. J.Enyeart J. A., J. Biol. Chem., 285, 20040 - 20050 (2010), "ACTH Induces CAv3.2. Current and mRNA by cAMP-dependent and cAMP-independent Mechanism"
  • 12. Lim J.-G., Lee J.-J., Park S.-H., Park J.-H., Kim S.-J., Cho H.-C., Baek W.-K., Kim D.-K.Song D.-K., Neurosci. Lett., 479, 13 - 17 (2010), "Glucagon-like Peptide-1 Protecs NSC-34 Motor Neurons against Glucosamine through Epac-mediated Uptake Enhancement"
  • 13. Rah S.-Y., Mushtaq M., Nam T.-S., Kim S. H.Kim U.-H., J. Biol. Chem., 285, 21877 - 21887 (2010), "Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+ Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells"
  • 14. Gerlo S., Verdood P.Kooijman R., J. Interferon Cytokine Res., 30, 883 - 891 (2010), "Modulation of Cytokine Production by Cyclic Adenosine Monophosphate Analogs in Human Leukocytes"
  • 15. Eijkelkamp N., Wang H. J., Garza-Carbajal A., Willemen H. L. D. M., Zwartkruis F. J., Wood J. N., Dantzer R., Kelley K. W., Heijnen C. J.Kavelaars A., J. Neurosci., 30, 12806 - 12815 (2010), "Low Nociceptor GRK2 Prolongs Prostaglandin E-2 Hyperalgesia via Biased cAMP Signaling to epac/Rap1, Protein Kinase C Epsilon, and MEK/ERK"
  • 16. Bogatcheva N. V., Zemskova M. A., Kovalenkov Y., Poirier C.Verin A. D., J. Cell. Physiol., 221, 750 - 759 (2009), "Molecular Mechanism Mediating Protective Effect of cAMP on Lipopolysaccharide (LPS)-induced Human Lung Microvascular Endothelial Cells (HLMVEC) Hyperpermeability"
  • 17. Sarkar S., Ravikumar B., Floto R. A.Rubinsztein D. C., Cell Death Differ., 16, 46 - 56 (2009), "Rapamycin and mTOR-independent Autophagy Inducers Ameliorate Toxicity of Polyglutamine-expanded Huntington and Related Proteinopathies"
  • 18. Grandoch M., de Jesus B. M., Oude Weernink P. A., Weber A. A., Jakobs K. H.Schmidt M., Cell Signal, 4, 609 - 621 (2009), "B Cell Receptor-induced Growth Arrest and Apoptosis in WEHI-231 Immature B Lymphoma Cells Involve Cyclic AMP and Epac Proteins"
  • 19. Voisin P.Bernard M., J. Neurochem., 110, 318 - 327 (2009), "Cyclic AMP-dependent Activation of Rhodopsin Gene Transcription in Cultured Retinal Precursor Cells of Chicken Embryo"
  • 20. Kojima F., Kapoor M., Kawai S., Yang L., Aronoff D. M.Crofford L. J., Prostaglandins Other Lipid Mediat., 89, 26 - 33 (2009), "Prostaglandin E (2) Activates Rap1 via EP2/EP4 Receptors and cAMP-signaling in Rheumatoid Synovial Fibroblasts: Involvement of Epac1 and PKA"
  • 21. Branham M. T., Bustos M. A., De Blas G. A., Rehmann H., Zarelli V. E., Trevino C. L., Darszon A., Mayorga L. S.Tomes C. N., J. Biol. Chem., 284, 24825 - 24839 (2009), "Epac Activates the Small G Proteins Rap1 and Rab3A to Achieve Exocytosis"
  • 22. Bastian P., Balcarek A., Altanis C., Strell C., Niggemann B., Zänker K. S.Entschladen F., Cancer Lett., 274, 1218 - 1234 (2009), "The Inhibitory Effect of Norepinephrine on the Migration of ES-2 Ovarian Carcinoma Cells Involves a Rap1-dependent Pathway"
  • 23. Waidmann O., Pleli T., Dvorak K., Baehr C., Mondorf U., Plotz G., Biondi R. M., Zeuzem S.Piiper A., J.Biol.Chem., 284, 32256 - 32263 (2009), "Inhibition of the Equilibrative Nucleoside Transporter 1 and Activation of A2A Adenosine Receptors by 8-(4-Chlorophenylthio)-modified cAMP Analogs and their Hydrolytic Products"
  • 24. Liu H., Enyeart J. A.Enyeart J. J., Mol. Pharmacol., 76, 1290 - 1301 (2009), "N6-substituted cAMP Analogs Inhibit bTREK-1K+ Channels and Stimulate Cortisol Secretion by a PKA-independent Mechanism"
  • 25. Yeager L. A., Chopra A. K.Peterson J. W., Infect. Immun., 77, 2530 - 2543 (2009), "Bacillus anthracis Edema Toxin Suppresses Human Macrophage Phagocytosis and Cytoskeletal Remodeling via the Protein Kinase A and Exchange Protein Activated by Cyclic AMP Pathways"
  • 26. Hochbaum D., Hong K., Barila G., Ribeiro-Neto F.Altschuler D. L., J. Biol. Chem., 283, 4464 - 4468 (2008), "Epac, in Synergy with PKA, is Required for cAMP-mediated Mitogenesis"
  • 27. Carmona G., Chavakis E., Koehl U., Zeiher A. M.Dimmeler S., Blood, 111, 2640 - 2646 (2008), "Activation of Epac Stimulates Integrin-dependent Homing of Progenitor Cells"
  • 28. Rein J., Voss M., Blenau W., Walz B.Baumann O., Am. J. Physiol. Cell. Physiol., 294, 56 - 65 (2008), "Hormone-induced Assembly and Activation of V-ATPase in Blowfly Salivary Glands is Mediated by Protein Kinase A"
  • 29. Misra U. K., Kaczowka S.Pizzo S. V., Cell. Signal, 20, 1459 - 1470 (2008), "The cAMP-activated GTP Exchange Factor, Epac1 Upregulates Plasma Membrane and Nuclear Akt Kinase Activitites in 8-CPT-2-O-Me-cAMP-stimulated Macrophages: Gene Silencing of the cAMP-activated GTP Exchange Epac1 Prevents 8-CPT-2-O-cAMP Activity in Macrophages"
  • 30. Huang S. K., Wettlaufer S. H., Chung J.Peters-Golden M., Am. J. Respir. Cell Mol. Biol., 39, 482 - 489 (2008), "Prostaglandin E2 Inhibits Specific Lung Fibroblast Functions Via Selective Actions of PKA and Epac-1"
  • 31. Kamio K., Sato T., Liu Y. J., Sugiura H., Togo S., Kobayashi T., Wang X., Mao L., Ahn Y., Holz O., Magnussen H.Rennard S. I., Am. J. Physiol. Cell. Mol. Physiol. L, 294, 1226 - 1236 (2008), "Prostacyclin Analogues Stimulate Vascular Endothelial Growth Factor (VEGF) Production from Human Lung Fibroblasts in Culture"
  • 32. Poppe H., Rybalkin S. D., Rehmann H., Hinds T. R., Tang X.-B., Christensen A. E., Schwede F., Genieser H.-G., Bos J. L., Doeskeland S. O., Beavo J. A.Butt E., Nature Methods, 5, 277 - 278 (2008), "Cyclic Nucleotide Analogs as Probes of Signaling Pathways"
  • 33. Holz G. G., Chepurny O. G.Schwede F., Cell. Signal., 20, 10 - 20 (2008), "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
  • 34. Kwak H.-J., Park K.-M., Choi H.-E., Chung K.-S., Lim H.-J.Park H.-Y., Cell. Signal., 20, 803 - 814 (2008), "PDE4 Inhibitor Roflumilast Protects Cardiomyocytes against NO-induced Apotosis via Activation of PKA and Epac Dual Pathway"
  • 35. Racke K., Haag S., Bahulayan A.Warnken M., Naunyn-Schmiedeberg's Arch. Pharmacol., 378, 193 - 201 (2008), "Pulmonary Fibroblasts, an Emerging Target for Anti-obstructive Drugs"
  • 36. Kang G., Leech C. A., Chepurny O. G., Coetzee W. A.Holz G. G., J. Physiol., 587, 1307 - 1319 (2008), "Role of the cAMP Sensor Epac as a Determinant of K-ATP Channel ATP-Sensitivity in Human Pancreatic β-Cells and RAT INS-1 Cells"
  • 37. Vliem M. J., Ponsioen B., Schwede F., Pannekoek W.-J., Riedl J., Kooistra M. R. H., Jalink K., Genieser H.-G., Bos J. L.Rehmann H., ChemBioChem, 9, 2052 - 2054 (2008), "8-pCPT-2'-O-Me-cAMP-AM: An Improved Epac-selective cAMP Analogue"
  • 38. Petersen R. K., Madsen L., Pedersen L. M., Hallenborg P., Hagland H., Viste K., Doeskeland S. O.Kristiansen K., Mol. Cell. Biol., 28, 3804 - 3816 (2008), "Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes"
  • 39. O'Neill J. S., Maywood E. S., Chesham J. E., Takahashi J. S.Hastings M. H., Science, 320, 949 - 953 (2008), "cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker"
  • 40. Hong K., Lou L., Gupta S., Ribeiro-Neto F.Altschuler D. L., J. Biol. Chem., 283, 23129 - 23138 (2008), "A Novel Epac-Rap-PP2A Signaling Module Controls cAMP-dependent Akt Regulation"
  • 41. Haag S., Warnken M., Juergens U. R.Racke K., Naunyn-Schmiedeberg's Arch. Pharmacol., 378, 617 - 630 (2008), "Role of Epac1 in Mediating Anti-proliferative Effects of Prostanoid EP2 Receptors and cAMP in Human Lung Fibroblasts"
  • 42. Gekel I.Neher E., J. Neurosci., 28, 7991 - 8002 (2008), "Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses"
  • 43. Kamio K., Liu X., Sugiura H., Togo S., Kobayashi T., Kawasaki S., Wang X. Q., Mao L., Ahn Y., Hogaboam C. M., Toews M. L.Rennard S. I., Am. J. Respir. Cell. Mol. Biol., 37, 113 - 120 (2007), "Prostacyclin Analogues Inhibit Fibroblast Contraction of Collagen Gels Through the cAMP-PKA Pathway"
  • 44. Huang S. K., Wettlaufer S. H., Hogaboam C. M., Aronoff D. M.Peters-Golden M., Am. J. Physiol. Lung Cell Mol. Physiol., 292, 405 - 413 (2007), "Prostaglandin E2 Inhibits Collagen Expression and Proliferation in Patient-derived Normal Lung Fibroblasts Via E Prostanoid 2 Receptor and cAMP Signaling"
  • 45. Li J., O'Connor K. L., Cheng X., Mei F. C., Uchida T., Townsend C. M.Evers B. M., Mol. Endocrinol., 21, 159 - 171 (2007), "Cyclic AMP-stimulated Neurotensin Secretion is Mediated Through Rap1 Downstream of Both Epac and PKA Signaling Pathways"
  • 46. Brock M., Fan F., Mei F. C., Li S., Gessner C., Woods V. L.Cheng X. D., J. Biol. Chem., 282, 32256 - 32263 (2007), "Confirmational Analysis of Epac Activation Using Amide Hydrogen/Deuterium Exchange Mass Spectrometry"
  • 47. Oestreich E. A., Wang H., Malik S., Kaproth-Joslin K. A., Blaxall B. C., Kelley G. G., Dirksen R. T.Smrcka A. V., J. Biol. Chem., 282, 5488 - 5495 (2007), "Epac-mediated Activation of Phospholipase C-epsilon Plays a Critical Role in Beta-adrenergic Receptor Dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes"
  • 48. Yano N., Suzuki D., Endoh M., Zhao T. C., Padbury J. F.Tseng Y. T., J. Biol. Chem., 282, 18819 - 18830 (2007), "A Novel Phosphoinosite 3-Kinase-dependent Pathway for Angiotensin II/AT-1 Receptor-mediated Induction of Collagen Synthesis in MES-13 Mesangial Cells"
  • 49. Dremier S., Milenkovic M., Blancquaert S., Dumont J. E., Doeskeland S. O., Maenhaut C.Roger P. R., Endocrinol., 148, 4612 - 4622 (2007), "Cyclic AMP-dependent Protein Kinases, but not Epac, Mediate TSH/cyclic AMP-dependent Regulation of Thyroid Cells"
  • 50. Wayne C. M., Fan H.-F., Cheng X.Richards J. S., Mol. Endocrinol., 21, 1940 - 1957 (2007), "FSH-induces Multiple Signaling Cascades: Evidence that Activation of SRC, RAS and the EGF Receptor are Critical for Granulosa Cell Differentiation"
  • 51. Hong J., Doebele R. C., Lingen M. W., Quilliam L. A., Tang W. J.Rosner M. R., J. Biol. Chem., 282, 19781 - 19787 (2007), "Anthrax Edema Toxin Inhibits Endothelial Cell Chemotaxis via Epac and Rap1"
  • 52. Bos J. L., Trends Biochem. Sci., 31, 680 - 686 (2006), "Epac Proteins: Multi-purpose cAMP Targets"
  • 53. Hashiguchi H., Nakazaki M., Koriyama N., Fukudome M., Aso K.Tei C., Diabetes Metab. Res. Rev., 22, 64 - 71 (2006), "Cyclic AMP/cAMP-GEF Pathway Amplifies Insulin Exocytosis Induced by CA(2+) and ATP in Rat Islet Beta-cells"
  • 54. Makranz C., Cohen G., Reichert F., Kodama T.Rotshenker S., Glia., 53, 441 - 448 (2006), "cAMP Cascade (PKA, Epac, Adenylyl Cyclase, Gi, and Phosphodiesterases) Regulates Myelin Phagocytosis Mediated by Complement Receptor-3 and Scavenger Receptor-AI/II in Microglia amd Macrophages"
  • 55. Aromataris E. C., Roberts M. L., Barritt G. J.Rychkov G. Y., J. Physiol., 573, 611 - 625 (2006), "Glucagon Activates Ca2+ and Cl-channels in Rat Hepatocytes"
  • 56. Kang G., Chepurny O. G., Malester B., Rindler M. J., Rehmann H., Bos J. L., Schwede F., Coetzee W. A.Holz G. G., J. Physiol.-London, 573, 595 - 609 (2006), "cAMP Sensor Epac as a Determinant of ATP-sensitive Potassium Channel Activity in Human Pancreatic Beta Cells and Rat INS-1 Cells"
  • 57. Hashiguchi H., Nakazaki M., Koriyama N., Fukudome M., Aso K.Tei C., Diabetes Metab. Res. Rev., 22, 64 - 71 (2006), "Cyclic AMP/cAMP-GEF Pathway Amplifies Insulin Exocytosis Induced by Ca2+ and ATP in Rat Islet Beta-cells"
  • 58. Liu G. H., Jacobo S. M. P., Hilliard N.Hockerman G. H., J. Pharmacol. Exp. Ther., 318, 152 - 160 (2006), "Differential Modulation of Ca(v)1.2 and Ca(v)1.3-Mediated Glucose-Stimulated Insulin Secretion by cAMP in INS-1 Cells: Distinct Roles for Exchange Protein Directly Activated by cAMP 2 (Epac2) and Protein Kinase A"
  • 59. Aronoff D. M., Carstens J. K., Chen G. H., Toews G. B.Peters-Golden M., J. Interferon Cytokine Res., 26, 827 - 833 (2006), "Differences Between Macrophages and Dentritic Cells in the Cyclic AMP-Dependent Regulation of Lipopolysaccaride-Induced Cytokine and Chemokine Synthesis"
  • 60. Holz G. G., Kang G., Harbeck M., Roe M. W.Chepurny O. G., J. Physiol.- London, 577, 5 - 15 (2006), "Cell Physiology of cAMP Sensor Epac"
  • 61. Bryn T., Mahic M., Enserink J. M., Schwede F., Aandahl E. M.Tasken K., J. Immunol., 176, 7361 - 7370 (2006), "The cyclic AMP-Epac1-Rap1 Pathway is Dissociated from Regulation of Effector Functions in Monocytes but Acquires Immunoregulatory Function in Mature Macrophages"
  • 62. Tronson N. C., Wiseman S. L., Olausson P.Taylor J. R., Nat. Neurosci., 9, 167 - 169 (2006), "Bidirectional Behavioral Plasticity of Memory Reconsolidation Depends on Amygdalar Protein Kinase A"
  • 63. Kiermayer S., Biondi R. M., Imig J., Plotz G., Haupenthal J., Zeuzem S.Piiper A., Mol. Biol. Cell., 16, 5639 - 5648 (2005), "Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 Cells"
  • 64. van Bemmelen M. X. P., Szczepanska-Konkel M., Jastorff B., Jankowski M.Angielski S., J. Physiol. Pharmacol., 56, 111 - 120 (2005), "Effect of cAMP Analogues on Glomerular Inulin Space of Isolated Rats Renal Glomeruli"
  • 65. Aronoff D. M., Canetti C., Serezani C. H., Luo M.Peters-Golden M., J. Immunology, 174, 595 - 599 (2005), "Cutting Edge: Macrophage Inhibition by cyclic AMP (cAMP): Differential Roles of Protein Kinase A and Exchange Protein Directly Activated by cAMP-1"
  • 66. Kang G., Chepurny O. G., Rindler M. J., Collis L., Chepurny Z., Li W.-H., Harbeck M., Roe M. W.Holz G. G., J. Physiol., 566, 173 - 188 (2005), "A cAMP and Ca2+ Coincidence Detector in Support of Ca2+-induced Ca2+ Release (CICR) in Pancreatic Beta Cells"
  • 67. Somekawa S., Fukuhara S., Nakaoka Y., Fujita H., Saito Y.Mochizuki N., Circ. Res., 97, 655 - 662 (2005), "Enhanced Functional Gap Junction Neoformation by Protein Kinase A-dependent and Epac-dependent Signals Downstream of cAMP in Cardiac Myocytes"
  • 68. Oynebraten I., Barois N., Hagelsteen K., Johansen F. E., Bakke O.Haraldsen G., J. Immunol., 175, 5358 - 5369 (2005), "Characterization of a Novel Chemokine-containing Storage Granule in Enthothelial Cells: Evidence for Preferential Exocytosis Mediated by Protein Kinase A and Diacylglycerol"
  • 69. Tiwari S., Felekkis K., Moon E. Y., Flies A., Sherr D. H.Lerner A., Blood, 103, 2661 - 2667 (2004), "Among Circulating Hematopoietic Cells, B-CLL Uniquely Expresses Functional EPAC1 but EPAC1-mediated Rap1 Activation does not Account for PDE4 Inhibitor-induced Apoptosis"
  • 70. Mahic M., Bryn T., Enserink J. M., Schwede F., Aandahl E. M.Tasken K., Poster #THP019 Montreal, 12, 0 - 0 (2004), "Modulation of Monocyte Activation by Cyclic AMP is Mainly Mediated Through Protein Kinase A"
  • 71. Genieser H.-G., Bos J. L., Christensen A. E., Doeskeland S. O., Havemann U., Manzau U., Rehmann H.Schwede F., Poster #THP016 Montreal, 12, 0 - 0 (2004), "Analogues of Cyclic AMP to Distinguish Between PKA and Epac"
  • 72. Ponsioen B., Zhao J., Riedl J., Zwartkruis F., van der Krogt G. N. M., Zaccolo M., Moolenaar W. H., Bos J. L.Jalink K., EMBO Rep., 5, 1176 - 1180 (2004), "Detecting cAMP-induced Epac Activation by Fluorescence Resonance Energy Transfer: Epac as a Novel cAMP Indicator"
  • 73. Kopperud R. K., Krakstad C., Selheim F.Doeskeland S. O., FEBS Lett., 546, 121 - 126 (2003), "cAMP Effector Mechanisms. Novel Twists for an 'Old' Signaling System"
  • 74. Christensen A. E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K. K., Martinez A., Maenhaut C., Bos J. L., Genieser H.-G.Doeskeland S. O., J. Biol. Chem., 278, 35394 - 35402 (2003), "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
  • 75. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 76. Christensen A. E., de Rooij J., Kopperud R. K., Nilsen O. K., Dao K. K., Schwede F., Bos J. L., Genieser H.-G.Doeskeland S. O., Abstract of the 13th Protein Kinase Symposium, 0, 5 - 5 (2002), "Comparison of the cAMP Binding Sites of EPAC-1 and cAMP-Kinase"
  • 77. Kopperud R. K., Christensen A. E., Kjaerland E., Viste K., Kleivdal H.Doeskeland S. O., J. Biol. Chem., 277, 13443 - 3448 (2002), "Formation of Inactive cAMP-Saturated Holoenzyme of cAMP-Dependent Protein Kinase under Physiological Conditions"
  • 78. Guo G. L.Klaassen C. D., J. Pharmacol. Exp. Ther., 299, 551 - 557 (2001), "Protein Kinase C Suppresses Rat Organic Anion Transporting Polypeptide 1- and 2-mediated Uptake"
  • 79. Schwede F., Maronde E., Genieser H.-G.Jastorff B., Pharmacol. Ther., 87, 199 - 226 (2000), "Cyclic Nucleotide Analogs as Biochemical Tools and Prospective Drugs"
  • 80. Bradbury N. A., J. Cell. Physiol., 185, 408 - 415 (2000), "Protein Kinase-A-mediated Secretion of Mucin from Human Colonic Epithelial Cells"
  • 81. Steagall W. K.Drumm M. L., Gastroenterology, 116, 1379 - 1388 (1999), "Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator-Dependent Short-Circuit Currents Across DeltaF508 Murine Intestines"
  • 82. Hansson V., Skalhegg B. S.Tasken K., J. Steroid Biochem. Mol. Biol., 69, 367 - 378 (1999), "Cyclic-AMP-Dependent Protein Kinase (PKA) in Testicular Cells. Cell Specific Expression, Differential Regulation and Targeting of Subunits of PKA"
  • 83. Cho-Chung Y. S., Jastorff B.Genieser H.-G., USA patent 5916, 843, 0 - 0 (1998), "Cyclic AMP Analogues, Individually and in Pairs, to Inhibit Neoplastic Cell Growth"
  • 84. Braun C. M., Huang S.-K., Kagey-Sobotka A., Lichtenstein L. M.Essayan D. M., Biochem. Pharmacol., 56, 871 - 879 (1998), "Co-Regulation of Antigen-Specific T Lymphocyte Responses by Type I and Type II Cyclic AMP-Dependent Protein Kinases (CAK)"
  • 85. Cho-Chung Y. S.Robins R. K., United States Patent 5752 of August 11, 792, 0 - 0 (1998), "8-Chloro cAMP and Related cAMP Compounds as Antineoplastic Agents"
  • 86. Parvathenani L. K., Buescher E. S., Chacon-Cruz E.Beebe S. J., J. Biol. Chem., 273, 6736 - 6743 (1998), "Type I cAMP-Dependent Protein Kinase Delays Apoptosis in Human Neutrophils at a Site Upstream of Caspase-3"
  • 87. Lamprecht G., Weinman E. J.Yun C.-H. C., J. Biol. Chem., 273, 29972 - 29978 (1998), "The Role of NHERF and E3KARP in the cAMP-Mediated Inhibition of NHE3"
  • 88. Singh A. K., Tasken K., Walker W., Frizzell R. A., Watkins S. C., Bridges R. J.Bradbury N. A., Am. J. Physiol., 275, 562 - 570 (1998), "Characterization of PKA Isoforms and Kinase-dependent Activation of Chloride Secretion in T84 Cells"
  • 89. Saati N., Ravid A., Liberman U. A.Koren R., In Vitro Cell Dev. Biol.-Plant, 33, 310 - 314 (1997), "1,25-Dihydroxyvitamin D-3 and Agents that Increase Intracellular Adenosine 3', 5'-Monophosphate Synergistically Inhibit Fibroblast Proliferation"
  • 90. Torgersen K. M., Vaage J. T., Levy F. O., Hansson V., Rolstad B.Tasken K., J. Biol. Chem., 272, 5495 - 5500 (1997), "Selective Activation of cAMP-Dependent Protein Kinase Type I Inhibits Rat Natural Killer Cell Cytotoxicity"
  • 91. Fladmark K. E., Gjertsen B. T., Doeskeland S. O.Vintermyr O. K., Biochem. Biophys. Res. Commun., 232, 20 - 5 (1997), "FAS/APO-1(CD95)-Induced Apoptosis of Primary Hepatocytes is Inhibited by cAMP"
  • 92. Holen I., Gordon P. B., Stroemhaug P. E.Seglen P. O., Eur. J. Biochem., 236, 163 - 170 (1996), "Role of cAMP in the Regulation of Hepatocytic Autophagy"
  • 93. Oestenstad B., Harboe M.Lea T., Eur. J. Immunol., 24, 2150 - 2154 (1996), "Differential Effects of Cyclic Adenosine 3', 5'- monophosphate on T Cell Cytotoxicity"
  • 94. Ree A. H., Maelandsmo G. M.Fodstad O., Clin. Exp. Metastas., 14, 381 - 388 (1996), "Regulation of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 in MCF-7 Cells - Comparison with Regulatory Mechanisms of PS2 Expression"
  • 95. Budillon A., Clair T., Hartmann N., Strong J., Sobukawa Y., Miki K., Worby A., Murray K. J.Cho-Chung Y. S., Int. J. Oncol., 9, 1113 - 1120 (1996), "Novel Growth Inhibitory Effect of 8-Cl-cAMP is Dependent on Serum Factors that Modulate Protein Kinase A Expression But Not the Hydrolysis of 8-Cl-cAMP"
  • 96. Sweet M. T., Jones K.Allis C. D., J. Cell Biol., 135, 1219 - 1228 (1996), "Phosphorylation of Linker Histone is Associated with Transcriptional Activation in a Normally Silent Nucleus"
  • 97. Steinberg R. A., Symcox M. M., Sollid S.Oegreid D., J. Biol. Chem., 271, 27630 - 27636 (1996), "Arginine 210 is not a Critical Residue for the Allosteric Interactions Mediated by Binding of cyclic AMP to Site A of Regulatory (RI alpha) Subunit of cyclic AMP-dependent Protein Kinase"
  • 98. Huq I., Dostmann W. R. G.Oegreid D., Biochem. J., 316, 337 - 343 (1996), "Isoleucine 368 is Involved in Low-Affinity Binding of N6-Modified cAMP Analogues to Site B of the Regulatory Subunit of cAMP-Dependent Protein Kinase I"
  • 99. Yu S.-M., Cheng Z.-J.Kuo S.-C., Br. J. Pharmacol., 114, 1227 - 1235 (1995), "Antiproliferative Effects of A02011-1, an Adenylate Cyclase Activator, in Cultured Vascular Smooth Muscle Cells of Rat"
  • 100. Gjertsen B. T., Mellgren G., Otten A., Maronde E., Genieser H.-G., Jastorff B., Vintermyr O. K., McKnight G. S.Doeskeland S. O., J. Biol. Chem., 270, 20599 - 20607 (1995), "Novel (Rp)-cAMPS Analogs as Tools for Inhibition of cAMP-Kinase in Cell Culture"
  • 101. Zorn M., Fladmark K. E., Oegreid D., Jastorff B., Doeskeland S. O.Dostmann W. R. G., FEBS Lett., 362, 291 - 294 (1995), "Ala 335 is Essential for High-affinity cAMP-binding of Both Sites A and B of cAMP-dependent Protein Kinase Type I"
  • 102. Boe R., Gjertsen B. T., Doeskeland S. O.Vintermyr O. K., Br. J. Cancer, 72, 1151 - 1159 (1995), "8-Chloro-cAMP Induces Apoptotic Cell Death in a Human Mammary Carcinoma Cell (MCF-7) Line"
  • 103. Vintermyr O. K., Böe R., Brustugun O. T., Maronde E., Aakvaag A.Doeskeland S. O., Endocrinology, 136, 2513 - 2520 (1995), "Cyclic Adenosine Monophosphate (cAMP) Analogs 8-Cl- and 8-NH(2)-cAMP Induce Cell Death Independently of cAMP Kinase-Mediated Inhibition of the G(1)/S Transition in Mammary Carcinoma Cells (MCF-7)"
  • 104. Downing G. J.Poisner A. M., Am. J. Physiol., 267, 954 - 960 (1994), "cAPK Mediates Placental Renin Secretion Stimulated by ß-Adrenoceptor Activation"
  • 105. Berg J. P., Ree A. H., Sandvik J. A., Tasken K., Landmark B. F., Torjesen P. A.Haug E., J. Biol. Chem., 269, 32233 - 32238 (1994), "1,25-Dihydroxyvitamin D3 Alters the Effect of cAMP in Thyroid Cells by Increasing the Regulatory Subunit Type IIBeta of the cAMP-Dependent Protein Kinase"
  • 106. Doeskeland S. O., Maronde E.Gjertsen B. T., Biochim. Biophys. Acta, 1178, 249 - 258 (1993), "The Genetic Subtypes of cAMP-dependent Protein Kinase - Functionally Different or Redundant"
  • 107. Zorn M., Maronde E., Jastorff B.Richter-Landsberg C., Eur. J. Cell Biol., 60, 351 - 357 (1993), "Differential Effects of Two Structurally Related N6-substituted cAMP Analogues on C6 Glioma Cells"
  • 108. Laurent-Cadoret V., Guillou F.Combarnous Y., Acta Endocrinol., 128, 555 - 562 (1993), "Involvement of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Isozymes in Tissue Plasminogen Activator Secretion by Rat Sertoli Cells Stimulated with Follicle-Stimulating Hormone in Vitro"
  • 109. Snyder H. M., Noland T. D.Breyer M. D., Am. J. Physiol., 263, 147 - 153 (1992), "cAMP- dependent Protein Kinase Mediates Hydrosmotic Effect of Vasopressin in Collecting Duct"
  • 110. Skalhegg B. S., Landmark B. F., Doeskeland S. O., Hansson V., Lea T.Jahnsen T., J. Biol. Chem., 267, 15707 - 15714 (1992), "Cyclic AMP-dependent Protein Kinase Type I Mediates the Inhibitory Effects of 3', 5'-Cyclic Adenosine Monophosphate on Cell Replication in Human T Lymphocytes"
  • 111. Hincke M. T.Soor S. K., Arch. Oral Biol., 37, 85 - 92 (1992), "Stimulation of Rat Parotid Secretion by cAMP Analogues That Synergistically Activate the Type II Isozyme of the cAMP-dependent Protein Kinase"
  • 112. Doeskeland S. O., Boe R., Bruland T., Vintermyr O. K., Jastorff B.Lanotte M., Method. Surveys Biochem. & Anal., E. Reid et al. (eds.). Royal Society Chem. Cambridge UK , Redwood Press Ltd., 21, 103 - 114 (1991), "Criteria Used to Judge That a Cellular Response is Mediated by Cyclic AMP"
  • 113. Lanotte M., Riviere J. B., Hermouet S., Houge G., Vintermyr O. K., Gjertsen B. T.Doeskeland S. O., J. Cell. Physiol., 146, 73 - 80 (1991), "Programmed Cell Death (Apoptosis) Is Induced Rapidly and With Positive Cooperativity by Activation of Cyclic Adenosine Monophosphate-Kinase I in a Myeloid Leukemia Cell Line"
  • 114. Van Lookeren Campagne M. M., Diaz F. V., Jastorff B.Kessin R. H., Cancer Res., 51, 1600 - 1605 (1991), "8-Chloroadenosine 3',5'-Monophosphate Inhibits the Growth of Chinese Hamster Ovary and Molt-4 Cells Through its Adenosine Metabolite"
  • 115. Van Lookeren Campagne M. M., Diaz F. V., Jastorff B., Winkler E., Genieser H.-G.Kessin R. W., J. Biol. Chem., 265, 5847 - 5854 (1990), "Characterization of the Yeast Low Km cAMP- Phosphodiesterase With cAMP Analogues"
  • 116. Cho-Chung Y. S., Cancer Res., 50, 7093 - 7100 (1990), "Role of Cyclic AMP Receptor Proteins in Growth, Differentiation, and Suppression of Malignancy: New Approaches to Therapy"
  • 117. Oegreid D., Ekanger R., Suva R. H., Miller J. P.Doeskeland S. O., Eur. J. Biochem., 181, 19 - 31 (1989), "Comparison of the Two Classes of Binding Sites ( A and B ) of Type I and Type II Cyclic AMP-dependent Protein Kinases Using Cyclic Nucleotide Analogs"
  • 118. Cho-Chung Y. S., Clair T., Tagliaferri P., Ally S., Katsaros D., Tortora G., Neckers L. M., Avery T. L., Crabtree G. W.Robins R. K., Cancer Invest., 7, 161 - 177 (1989), "Site-selective Cyclic AMP Analogs as New Biological Tools in Growth Control, Differentiation, and Proto-oncogene Regulation"
  • 119. Van Sande J., Lefort A., Beebe S., Roger P., Perret J., Corbin J.Dumont J. E., Eur. J. Biochem., 183, 699 - 708 (1989), "Pairs of cyclic AMP Analogs, that are Specifically Synergistic for Type I and Type II cAMP-dependent Protein Kinases, Mimic Thyrotropin Effects on the Function, Differentiation Expression and Mitogenesis of Dog Thyroid Cells"
  • 120. Francis S. H., Noblett B. D., Todd B. W., Wells J. N.Corbin J. D., Mol. Pharmacol., 34, 506 - 517 (1988), "Relaxation of Vascular and Tracheal Smooth Muscle by Cyclic Nucleotide Analogs That Preferentially Activate Purified cGMP-Dependent Protein Kinase"
  • 121. Tortora G., Tagliaferri P., Clair T., Colamonici O., Neckers L. M., Robins R. K.Cho-Chung J.-S., Blood, 71, 230 - 233 (1988), "Site-selective Cyclic AMP Analogs at Micromolar Concentrations Induce Growth Arrest and Differentiation of Acute Promyelocytic, Chronic Myelocytic, and Acute Lymphocytic Human Leukemia Cell Lines"
  • 122. Tagliaferri P., Katsaros D., Clair T., Ally S., Tortora G., Neckers L. M., Rubalcava B., Parandoosh Z., Chang Y.-A., Revankar G. R., Crabtree G. W., Robins R. K.Cho-Chung Y. S., Cancer Res., 48, 1642 - 1650 (1988), "Synergistic Inhibition of Growth of Breast and Colon Human Cancer Cell Lines by Site-selective Cyclic AMP Analogs"
  • 123. Beebe S. J., Beasley-Leach A.Corbin J. D., Methods Enzymol., 159, 531 - 540 (1988), "cAMP Analogs Used to Study Low-km, Hormone-sensitive Phosphodiesterase"
  • 124. Katsaros D., Tortora G., Tagliaferri P., Clair T., Ally S., Neckers L. M., Robins R. K.Cho-Chung Y. S., FEBS Lett., 223, 97 - 103 (1987), "Site-selective Cyclic AMP Analogs Provide a New Approach in the Control of Cancer Cell Growth"
  • 125. Steinberg R. A., Russell J. L., Murphy C. S.Yphantis D. A., J. Biol. Chem., 262, 2664 - 2671 (1987), "Activation of Type I Cyclic AMP- dependent Protein Kinases with Defective Cyclic AMP-binding Sites"
  • 126. Beebe S. J., Holloway R., Rannels S. R.Corbin J. D., J. Biol. Chem., 259, 3539 - 3547 (1984), "Two Classes of cAMP Analogs Which Are Selective for the Two Different cAMP-binding Sites of Type II Protein Kinase Demonstrate Synergism When Added Together to Intact Adipocytes"
  • 127. Oegreid D., Doeskeland S. O.Miller J. P., J. Biol. Chem., 258, 1041 - 1049 (1983), "Evidence That Cyclic Nucleotides Activating Rabbit Muscle Protein Kinase I Interact with Both Types of cAMP Binding Sites Associated with the Enzyme"
  • 128. Robinson-Steiner A. M.Corbin J. D., J. Biol. Chem., 258, 1032 - 1040 (1983), "Probable Involvement of Both Intrachain cAMP Binding Sites in Activation of Protein Kinase"
  • 129. Nishikori K.Maeno H., J. Biol. Chem., 254, 6099 - 6109 (1979), "Close Relationship between Adenosine 3',5'-Monophosphate-dependent Endogenous Phosphorylation of a Specific Protein and Stimulation of Calcium Uptake in Rat Uterine Microsomes"
  • 130. Kuo J. F., Miyamoto E.Reyes P. L., Biochem. Pharmacol., 23, 2011 - 2021 (1974), "Activation and Dissociation of Adenosine 3', 5'- Monophosphate-dependent and Guanosine 3', 5'- monophosphate-dependent Protein Kinases by Various Cyclic Nucleotide Analogs"
  • 131. Du Plooy M., Michal G., Weimann G., Nelboeck M.Paoletti R., Biochim. Biophys. Acta, 230, 30 - 39 (1971), "Cyclophosphates I. Effect of Various Cyclophosphates on Phosphorylase b Kinase Activation"
  • 132. Michal G., Nelböck M.Weimann G., Z. Anal. Chem., 252, 189 - 193 (1970), "Cyclophosphate III. Spaltung Verschiedener Cyclophosphate durch Phosphodiesterase aus Herz und Fettgewebe"
  • 133. Falbriard J.-G., Posternak T.Sutherland E. W., BBA, 148, 99 - 105 (1967), "Preparation of Derivatives of Adenosine 3', 5'-Phosphate"
  • 134. Rah S.-Y., Kwak J.-Y.Kim U.-H., Scientific Reports, 0, 0 - 0 (0), "ADP-Ribose/TRM2-mediated Ca2+ Signaling is Essential for Cytolytic Degranulation and Antitumor Activity of Natural Killer Cells"

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