Adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-cAMPS ), high purity grade
Membrane permeant and PDE-resistant inhibitor of PKA
C10H11N5O5PS•Na; MW 367.3; λmax 258 nm; ε 15000; sodium salt; purity > 99% HPLC. Specially purified from adenosine, cAMP and Sp-cAMPS. For other salt forms please inquire. Competitive inhibitor of protein kinase A type I and II (cyclic AMP antagonist). Prefers type II of protein kinase A. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic compared to cAMP. Detailed technical information and updated reference list available on request. Rp-cAMPS is also available in an inexpensive lower purity form ( A 002 T Economy Grade ) and as bulk ware. Ref.: Gjertsen et al., J. Biol. Chem., 270, 20599 - 20607 (1995).
Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI
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