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pGpG

5'- Phosphoguanylyl- (3' −> 5')- guanosine ( pGpG / 5'-p(rG)p(rG) ), sodium salt
c-diGMP metabolite
Cat. No.: P 023
    
CAS No.: [33008-99-0]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: P 023-01
Unit: 1 µmol / ~0.7 mg
$132.00

For other salt forms please inquire. First metabolic degradation product of the bacterial second messenger c-diGMP (Cat. No. C 057). Detailed technical information available. Reference: Christen et al., Proc. Nat. Acad. Sci. USA, 104, 4112 - 4117 (2007).

 

Significant price cut: Now offered in 1 µmol units instead of 0.1 µmol.

Cat. No. P 023
CAS number [33008-99-0]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₆N₁₀O₁₅P₂ (free acid)
Molecular weight [g/mol] 708.4 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23000
  • 1. Lolicato M., Bucchi A., Arrigoni C., Zucca S., Nardini M., Schroeder I., Simmons K., Aquila M., DiFrancesco D., Bolognesi M., Schwede F., Kashin D., Fishwick C. W. G., Johnson A. P., Thiel G.Moroni A., Nat. Chem. Biol., 10, 457 - 462 (2014), "Cyclic Dinucleotides bind the C-linker of HCN4 to Control Channel cAMP Responsiveness"
  • 2. Stelitano V., Giardina G., Paiardini A., Castiglione N., Cutruzzola F.Rinaldo S., PLoS ONE, 8, 0 - 0 (2013), "C-diGMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG"
  • 3. Gao X., Mukherjee S., Matthews P. M., Hammad L. A., Kearns D. B.Dann C. E., J. Bacteriol., 195, 4782 - 4792 (2013), "Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway"
  • 4. Rao F., See R. Y., Zhang D., Toh D. C., Ji Q.Liang Z.-X., J. Biol. Chem., 285, 473 - 482 (2010), "YybT is a Signaling Protein that Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity"
  • 5. Sudarsan N., Lee E. R., Weinberg Z., Moy R. H., Kim J. N., Link K. H.Breaker R. R., Science, 321, 411 - 413 (2008), "Riboswitches in Eubacteria Sense the Second Messenger cyclic di-GMP"
  • 6. Christen M., Christen B., Allan G. M., Folcher M., Jenoe P., Grzesiek S.Jenal U., Proc. Natl. Acad. Sci. USA, 104, 4112 - 4117 (2007), "DgrA is a Member of a New Family of Cyclic Diguanosine Monophosphate Receptors and Controls Flagellar Motor Function in Caulobacter Crescentus"
  • 7. Römling U., Gomelsky M.Galperin M. Y., Mol. Microbiol., 57, 629 - 639 (2005), "C-di-GMP: the Dawning of a Novel Bacterial Signalling System"
  • 8. Christen M., Christen B., Folcher M., Schauerte A.Jenal U., J. Biol. Chem., 280, 30829 - 30837 (2005), "Identification and Characterization of a Cyclic di-GMP-specific Phosphodiesterase and Its Allosteric Control by GTP"