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pApA

5'- Phosphoadenylyl- (3' −> 5')- adenosine ( pApA / 5'-p(rA)p(rA) ), sodium salt
Potential metabolite of the bacterial second messenger c-diAMP
Cat. No.: P 033
    
CAS No.: [3593-47-3]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: P 033-01
Unit: 1 µmol / ~0.7 mg
$132.00

For other salt forms please inquire. Potential metabolic degradation product of c-diAMP (Cat. No. C 088). c-diAMP is an additional purine-based signalling nucleotide in prokaryotes (Witte et al., Mol. Cell, 30, 167 - 178 (2008)). Detailed technical information available. Reference: Rao et al., J. Biol. Chem., 285, 473 - 482 (2010).

 

Significant price cut: Now offered in 1 µmol units instead of 0.1 µmol.

Cat. No. P 033
CAS number [3593-47-3]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₆N₁₀O₁₃P₂ (free acid)
Molecular weight [g/mol] 676.5 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27000
  • 1. Sureka K., Choi P. H., Precit M., Delince M., Pensinger D. A., Huynh T. N., Jurado A. R., Goo Y. A., Sadilek M., Iavarone A. T., Sauer J. D., Tong L.Woodward J. J., Cell, 158, 1389 - 1401 (2014), "The Cyclic Dinucleotide c-diAMP is an Allosteric Regulator of Metabolic Enzyme Function"
  • 2. Witte C. E., Whiteley A. T.Burke T. P., mBio, 4(3), 4, 0 - 0 (2013), "Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection"
  • 3. Bai Y., Yang J., Eisele L. E., Underwood A. J., Koestler B. J., Waters C. M., Metzger D. W.Bai G., Journal of Bacteriology, 195, 5123 - 5132 (2013), "Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence"
  • 4. Rao F., See R. Y., Zhang D., Toh D. C., Ji Q.Liang Z.-X., J. Biol. Chem., 285, 473 - 482 (2010), "YybT is a Signaling Protein that Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity"
  • 5. Witte G., Hartung S., Büttner K.Hopfner K.-P., Mol. Cell, 30, 167 - 178 (2008), "Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates"