This website uses cookies to ensure proper functionality of the shopping cart and checkout progress. By continuing to browse the site you are agreeing to the use of cookies. Click here to learn about cookie settings.
Thymidine analogue of interest in antiviral research. Inhibits DNA polymerase ß and thymidine kinase. Detailed technical information available. References: Yamanaka et al., Biol. Pharmaceut. Bull., 20, 163 - 167 (1997); Seiser et al., J. Mol. Biol.,265, 153 - 160 (1997). This compound is also part of the Ko-Libri compound library (K 001)
Cat. No.
D 040
CAS number
[3416-05-5]
Purity
> 98% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₁₀H₁₄N₂O₄
Molecular weight [g/mol]
226.2
Absorption max [nm]
267
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
9600
1. Sutterluety H.Seiser C., J. Mol. Biol., 265, 153 - 160 (1997), "Thymidine Inhibits the Growth-Arrest-Specific Degradation of Thymidine Kinase Protein in Transfected L Fibroblasts"
2. Yamanaka K., Hayashi H., Kato K., Hasegawa A., Oku N.Okada S., Biol. Pharm. Bull., 20, 163 - 167 (1997), "DNA Single-Strand Breaks in L-132 Cells Resulting from Inhibition of Repair Polymerization Shortly after Exposure to Dimethylarsinic Acid"
3. Buzayan J. M., Feldstein P. A., Segrelles C.Bruening G., Nucleic Acids Res., 16, 4009 - 4023 (1988), "Autolytic Processing of a Phosphorothioate Diester Bond"
4. Suzuki S., Lee B., Luo W., Tovell D., Robins M. J.Tyrrell D. L. J., Biochem. Biophys. Res. Commun., 156, 1144 - 1151 (1988), "Inhibition of Duck Hepatitis B Virus Replication by Purine 2',3'-Dideoxynucleosides"