Useful as starting structure for 2'-deoxyadenosine nucleotides modified in position 8, as cytotoxic nucleoside and of potential interest in research on bromine-stressed DNA. Detailed technical information available. References: Liu & Verdine, Tetrahedr. Lett., 33, 4265 - 4268 (1992); Coomber et al., Int. J. Parasitol., 24, 357 - 365 (1994); Jimenez et al., Photochem. Photobiol. Sci., 3, 1042 - 1046 (2004). This compound is also part of the Ko-Libri compound library (K 001)
| Cat. No. | B 027 |
| CAS number | [14985-44-5] |
| Purity | > 98% HPLC |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₀H₁₂BrN₅O₃ |
| Molecular weight [g/mol] | 330.1 |
| Absorption max [nm] | 264 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 17000 |
- 1. Jimenez L. B., Encinas S., Miranda M. A., Navacchia M. L.Chatgilialoglu C., Photochem. Photobiol. Sci., 3, 1042 - 1046 (2004), "The Photochemistry of 8-Bromo-2'-Deoxyadenosine. A Direct Entry to Cyclopurine Lesions"
- 2. Shen Z., Mitra S. N., Wu W., Chen Y., Yang Y., Qin J.Hazen S. L., Biochemistry, 40, 2041 - 2051 (2001), "Eosinophil Peroxidase Catalyzes Bromination of Free Nucleosides and Double-Stranded DNA"
- 3. Coomber D. W. J., O'Sullivan W. J.Gero A. M., Int. J. Parasitol., 24, 357 - 365 (1994), "Adenosine Analogues as Antimetabolites against Plasmodium Falciparum Malaria"
- 4. Liu J.Verdine G. L., Tetrahedron Lett., 33, 4265 - 4268 (1992), "Synthesis of Photoactive DNA: Incorporation of 8-Bromo-2'-Deoxyadenosine into Synthetic Oligodeoxynucleotides"
