0 Items - $0.00
Categories
A to Z

GTP-γ-S

Guanosine- 5'- O- (3- thiotriphosphate) ( GTP-γ-S ), sodium salt
Cat. No.: G 019
    
CAS No.: [37589-80-3]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: G 019-05
Unit: 5 µmol / ~2.7 mg
$100.00

For other salt forms or a guaranteed higher purity please inquire. GTP analogue with increased metabolic stability which activates G proteins. Useful for modification with SH-reactive reporters or for connection to structures with SH-groups via a disulfide bond. Detailed technical information available. Reference: Gilman, Ann. Rev. Biochem., 56, 615 - 649 (1987).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 8.5.

Cat. No. G 019
CAS number [37589-80-3]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 8.5
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₆N₅O₁₃P₃S (free acid)
Molecular weight [g/mol] 539.3 (free acid)
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
  • 1. Menon J., Doebele R. C., Gomes S., Bevilacqua E., Reindl K. M.Rosner M. R., PLoS One, e49893, 7, 0 - 0 (2012), "A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer"
  • 2. Haag S., Warnken M., Juergens U. R.Racke K., Naunyn-Schmiedeberg's Arch. Pharmacol., 378, 617 - 630 (2008), "Role of Epac1 in Mediating Anti-proliferative Effects of Prostanoid EP2 Receptors and cAMP in Human Lung Fibroblasts"
  • 3. Kinukawa M., Oda S., Shirakura Y., Okabe M., Ohmuro J., Baba S. A., Nagata M.Aoki F., FEBS Lett., 580, 1515 - 1520 (2006), "Roles of cAMP in Regulating Microtubule Sliding and Flagellar Bending in Demembranated Hamster Spermatozoa"
  • 4. Cunliffe J. M., Sunahara R. K.Kennedy R. T., Anal. Chem., 78, 1731 - 1738 (2006), "Detection of Adenylyl Cyclase Activity Using a Fluorescent ATP Substrate and Capillary Electrophoresis"
  • 5. Liao Y., Kariya K.-I., Hu C.-D., Shibatohge M., Goshima M., Okada T., Watari Y., Gao X., Jin T.-G., Yamawaki-Kataoka Y.Kataoka T., J. Biol. Chem., 274, 37815 - 37820 (1999), "Ra-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, is Conserved between Nematode and Humans"
  • 6. Schäfer R.Reiser G., Br. J. Pharmacol., 121, 913 - 922 (1997), "Characterization of 35S-ATP-alpha-S and 3H-alpha, beta-MEATP Binding Sites in Rat Brain Cortical Synaptosomes: Regulation of Ligand Binding by Divalent Cations"
  • 7. Brown J. E.Kelman E. S., Biochem. Biophys. Res. Commun., 224, 684 - 689 (1996), "Ca2+ Induces an Increase in cGMP-Phosphodiesterase Activity in Squid Retinal Photoreceptors"
  • 8. Peters D. J. M., Bominaar A. A., Snaar-Jagalska B. E., Brandt R., Van Haastert P. J. M., Ceccarelli A., Williams J. G.Schaap P., Proc. Natl. Acad. Sci. USA, 88, 9219 - 9223 (1991), "Selective Induction of Gene Expression and Second-Messenger Accumulation in Dictyostelium Discoideum by the Partial Chemotactic Antagonist 8-p-chlorophenylthioadenosine 3´,5´-cyclic Monophosphate"
  • 9. Gilman A. G., Ann. Rev. Biochem., 56, 615 - 649 (1987), "G Proteins: Transducers of Receptor-Generated Signals"
  • 10. Eckstein F., Nucleosides Nucleotides, 4, 77 - 79 (1985), "Stabilisation of DNA by Incorporation of Phosphothioate Groups"
  • 11. Rösch P., Kalbitzer H. R.Goody R. S., FEBS Lett., 121, 211 - 214 (1980), "31P-NMR Spectra of Thiophosphate Analogues of Guanosine Nucleotides"
  • 12. Eckstein F., Accounts of Chemical Research, 12, 204 - 210 (1979), "Phosphorothioate analogues of nucleotides"
  • 13. Goody R. S.Eckstein F., J. Am. Chem. Soc., 93, 6252 - 6257 (1971), "Thiophosphate Analogs of Nucleoside Di- and Triphosphates"