0 Items - $0.00
Categories
A to Z

2-MeS-ATP

2- Methylthioadenosine- 5'- O- triphosphate ( 2-MeS-ATP ), sodium salt
P2Y purinoceptor agonist
Cat. No.: M 021
    
CAS No.: [43170-89-4]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: M 021-05
Unit: 5 µmol / ~2.8 mg
$87.00

For other salt forms or a guaranteed higher purity please inquire.
Agonist of P2Y purinoceptors. Inhibits soluble guanylate cyclase. Detailed technical information available. Reference: Ruiz-Stewart et al., Eur. J. Biochem., 269, 2186 - 2193 (2002).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. M 021
CAS number [43170-89-4]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₁H₁₈N₅O₁₃P₃S (free acid)
Molecular weight [g/mol] 553.3 (free acid)
Absorption max [nm] 277
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14700
UV pH value 11
  • 1. Guzman-Aranguez A., Díez l. M., Martín-Gil A., Gualix J., Miras-Portugal M. T.Pintor J., Exp. Eye. Res., 101, 49 - 55 (2012), "Effect of Diinosine Polyphosphates on Intraocular Pressure in Normotensive Rabbits"
  • 2. Swennen E. L., Bast A.Dagnelie P. C., Biochem. Biophys. Res. Commun., 348, 1194 - 1199 (2006), "Purinergic Receptors Involved in the Immunomodulatory Effects of ATP in Human Blood"
  • 3. Marcet B., Chappe V., Delmas P.Verrier B., J. Pharmacol. Exp. Ther., 309, 533 - 539 (2004), "Pharmacological and Signaling Properties of Endogenous P2Y1 Receptors in Cystic Fibrosis Transmembrane Conductance Regulator-expressing Chinese Hamster Ovary Cells"
  • 4. Unterberger U., Moskvina E., Scholze T., Freissmuth M.Böhm S., Br. J. Pharmacol., 135, 673 - 684 (2002), "Inhibition of Adenylyl Cyclase by Neuronal P2Y Receptors"
  • 5. Nahum V., Zündorf G., Levesque S. A., Beaudoin A. R., Reiser G.Fischer B., J. Med. Chem., 45, 5384 - 5396 (2002), "Adenosine 5'-O-(1-Boranotriphosphate) Derivatives as Novel P2Y1 Receptor Agonists"
  • 6. Ruiz-Stewart I., Kazerounian S., Pitari G. M., Schulz S.Waldman S. A., Eur. J. Biochem., 269, 2186 - 2193 (2002), "Soluble Guanylate Cyclase is Allosterically Inhibited by Direct Interaction with 2-substituted Adenine Nucleotides"
  • 7. Qi A.-D., Zambon A. C., Insel P. A.Nicholas R. A., Mol. Pharmacol., 60, 1375 - 1382 (2001), "An Arginine/Glutamine Difference at the Juxtaposition of Transmembrane Domain 6 and the Third Extracellular Loop Contributes to the Markledly Differnet Nucleotide Selectivities of Human and Canine P2Y(11) Receptors"
  • 8. Ferreira Z. S.Markus R. P., Eur. J. Pharmacol., 415, 151 - 156 (2001), "Characterisation of P2Y(1)-like Receptor in Cultured Rat Pineal Glands"
  • 9. Vohringer C., Schäfer R.Reiser G., Biochem. Pharmacol., 59, 791 - 800 (2000), "A Chimeric Rat Brain P2Y(1) Receptor Tagged With Green-Fluorescent Protein: High-affinity Ligand Recognition of Adenosine Diphosphates and Triphosphates and Selectivity Identical to that of the Wild-type Receptor"
  • 10. King B. F., Wildmann S. S., Ziganshina L. E., Pintor J.Burnstock G., Br. J. Pharmacol., 121, 1445 - 1453 (1997), "Effects of Extracellular pH on Agonism and Antagonism at a Recombinant P2X(2) Receptor"
  • 11. Picher M., Sevigny J., D'Orleans-Juste P.Beaudoin A. R., Biochem. Pharmacol., 51, 1453 - 1460 (1996), "Hydrolysis of P2-Purinoreceptor Agonists by a Purified Ectonucleotidase from the Bovine Aorta, the ATP-Diphosphohydrolase"
  • 12. Burnstock G., Cusack N. J., Hills J. M., MacKenzie I.Meghji P., Br. J. Pharmacol., 79, 907 - 913 (1983), "Studies on the Stereoselectivity of the P2-Purinoceptor"
  • 13. Cusack N. J.Hourani S. M. O., Br. J. Pharmacol., 75, 397 - 400 (1982), "Specific but Noncompetitive Inhibition by 2-Alkylthio Analogues of Adenosine 5'-monophosphate and Adenosine 5'-triphosphate of Human Platelet Aggregation Induced by Adenosine 5'-diphosphate"