Basket (0 Items) - Amount: 0.00$8- Bromo- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'-cyclic monophosphate ( 8-Br-PET-cGMP )
Site-selective analogue of cyclic GMP
Cat. No.: P 003 CAS No.: [144510-04-3]
C18H14BrN5O7P•Na; MW 546.2; λmax 256 nm; ε 40000; sodium salt, purity > 98% HPLC. For other salt forms or metabolites please inquire. Potent membrane-permeant activator of both isozymes I α and I ß of cGMP-dependent protein kinase while only a poor stimulator of type II. Common agonists such as 8-Br-cGMP or 8-pCPT-cGMP mainly activate kinase subtypes I α and II. 8-Br-PET-cGMP is one of the best activators of isozyme I ß and one of the best cyclic nucleotide muscle relaxants. Detailed technical information and updated reference list available. Reference: Sekhar et al., Mol. Pharmacol., 42, 103 - 108 (1992).
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