Basket (0 Items) - Amount: 0.00$8- Piperidinoadenosine- 3', 5'- cyclic monophosphate ( 8-PIP-cAMP )
Site-selective PKA agonist
Cat. No.: P 002 CAS No.: [31357-06-9]
C15H20N6O6P•Na; MW 434.3; λmax 273 nm; ε 15000; sodium salt, purity > 98% HPLC. For other salt forms or metabolites please inquire. Site selective cyclic AMP analogue with high selectivity for site A of protein kinase A type I and for site B of type II. Acts synergistically together with analogues having opposite site selectivity. Combination with e.g. 2-Cl-8-MA-cAMP (Cat. No. C 080) preferentially activates type I, while e.g. with 6-MBC-cAMP (Cat. No. M 012) selects type II. Increased metabolic stability and membrane permeability compared to cAMP. Detailed technical information and updated references available. Reference: Skalhegg et al., J. Biol. Chem., 267, 15707 - 15714 (1992).
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