Basket (0 Items) - Amount: 0.00$8- (2- [7- Nitro- 4- benzofurazanyl]aminoethylthio)guanosine- 3', 5'- cyclic monophosphate ( 8-NBD-cGMP )
Fluorescent analogue of cyclic GMP
Cat. No.: N 001 CAS No.: [115993-88-9]
C18H17N9O10PS•Na; MW 605.4; λmax 276/344/479 nm; sodium salt, purity > 95% HPLC. For other salt forms or metabolites please inquire. Potent membrane-permeant fluorescent activator of both isozymes I a and I ß of cGMP-dependent protein kinase. While 8-NBD-cGMP is almost nonfluorescent in aqueous solutions, it fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites; λexc 475 nm, λem 525 nm. Detailed technical information available. Reference: Ruf et al. in Heilmeyer (ed.), Signal Transduction and Protein Phosphorylation, Ser. A, Life Sci., 135, 99 - 104 ( 1987), Plenum Press, NATO ASI.
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