(7- Diethylaminocoumarin- 4- yl)methylguanosine- 3', 5'- cyclic monophosphate ( DEACM-caged cGMP )
C24H27N6O9P • 3 H2O; MW 628.5; λmax 403 nm; ε 19300; purity > 98% HPLC. Axial isomer, for the corresponding isomeric mixture please inquire. DEACM-caged cGMP is an only weakly fluorescent, caged precursor of the second messenger cyclic cGMP, which upon irradiation, releases both cGMP and a strongly fluorescent coumarin analogue. High lipophilicity but still reasonable solubility in aqueous systems. Detailed technical information available. Reference: Hagen et al., Angew. Chem. Int. Ed., 40, 1046 - 1048 (2001).
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