C₁₂H₁₀Cl₂N₂O₅PS^.Na; MW 419.2; λ_max 254 nm; ε 6400; sodium salt; purity > 99%. For other salt forms please inquire. Potent site-selective activator of cAMP- dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian PDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency. The corresponding Rp- isomer is available as well (Cat. No. D 013). Detailed technical information and updated reference list available on request. Ref.: Sandberg et al., Biochemistry, 279, 521 - 527 (1991).

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