5, 6- Dichlorobenzimidazole riboside- 3', 5' - cyclic monophosphorothioate, Sp- isomer ( Sp-5,6-DCl-cBIMPS )

Powerful PDE-resistant and membrane-permeant PKA agonist
Cat. No.: D 014   CAS No.: [120912-54-1]   
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C12H10Cl2N2O5PS.Na; MW 419.2; λmax 254 nm; ε 6400; sodium salt; purity > 99%. For other salt forms please inquire. Potent site-selective activator of cAMP- dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian PDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency. The corresponding Rp- isomer is available as well (Cat. No. D 013). Detailed technical information and updated reference list available on request. Ref.: Sandberg et al., Biochemistry, 279, 521 - 527 (1991).

Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI

 



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