2'- Deoxyadenosine- 5'- O- (1- thiotriphosphate), Sp- isomer ( Sp-dATP-α-S )
C10H16N5O11P3S; MW 507.3 (free acid); λmax 258 nm; ε 15200; sodium salt, purity > 98% HPLC. For other salt forms please inquire. Useful for modulation of dATP-responsive receptors and determination of their stereospecificity. Increased metabolic stability compared to dATP. Accepted by DNA polymerase for incorporation of phosphorothioate into DNA. Detailed technical information available. Reference: Eckstein et al., Methods Enzymol., 262, 189 - 202 (1995). Useful for pyrosequencing techniques: Ronaghi et al., Science, 281, 363 - 365 (1998), Gharizadeh et al., Anal. Biochem., 301, 82 - 90 (2002).
Vial containing 500 µl of 10 mM aqueous solution of pH 7.6.
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