Basket (0 Items) - Amount: 0.00$8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-2'-O-Me-cAMPS )
C17H16ClN5O5PS2.Na; MW 523.9; λmax 282 nm; ε 16000; sodium salt; purity > 98% HPLC. For other salt forms please inquire. Hydrolysis-resistant form of 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041), a specific activator of the exchange protein directly activated by cyclic AMP (Epac) or cAMP-GEF, respectively. The compound does not activate protein kinase A, has high lipophilicity and membrane permeability and is not metabolized by phosphodiesterases. Detailed technical information available. Reference: Laxman et al., PNAS, 103, 19194 - 19199 (2006). Selected references for 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041): Enserink et al., Nature Cell Biol., 4, 901 - 906 (2002); Kang et al., J. Biol. Chem., 278, 8279 - 8285 (2003); Christensen et al., J. Biol. Chem., 278, 35394 - 35402 (2003).
Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
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