Highly membrane-permeant precursor of the PKG activator 8-pCPT-cGMP (Cat. No. C 009). Metabolic activation by esterases releases the active analogue. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
| Cat. No. | C 033 |
| CAS number | [272445-72-4] |
| Purity | > 97% HPLC for mixture of isomers |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₉H₁₉ClN₅O₉PS |
| Molecular weight [g/mol] | 559,9 |
| Modifications | 8-cGMP |
| Target | PKG (cGK) Activator |
| Absorption max [nm] | 276 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 21500 |
- 1. Schwede F., Brustugun O. T., Zorn-Kruppa M., Doeskeland S. O.Jastorff B., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000), "Membrane-permeant, Bioactivatable Analogues of cGMP as Inducers of Cell Death in IPC-81 Leukemia Cells"
