Basket (0 Items) - Amount: 0.00$8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-CPT-cAMPS )
Membrane-permeant and PDE-resistant PKA inhibitor
Cat. No.: C 011 CAS No.: [129735-01-9]
C16H14ClN5O5PS2•Na; MW 509.8; λmax 282 nm; ε 16000; sodium salt; purity > 99% HPLC; highly purified, fluorescent impurities removed. For other salt forms please inquire. Lipophilic analog of Rp-cAMPS (Cat. No. A 002). Potent competitive inhibitor of protein kinase A type I and II (cyclic AMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Considerably more lipophilic and membrane-permeant compared to Rp-8-Br-cAMPS (Cat. No. B 001). Detailed technical information and updated reference list available on request. Reference: Weisskopf et al., Science, 265, 1878 - 1882 (1994).
Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI
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