Basket (0 Items) - Amount: 0.00$8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), fluorescence grade
Lipophilic activator of both cAMP- and cGMP-dependent protein kinase and of Epac
Cat. No.: C 010 CAS No.: [93882-12-3] Bulk available
C16H14ClN5O6PS.Na; MW 493.8; λmax 282 nm; ε 16000; sodium salt, purity > 99% HPLC; highly purified, typical fluorescent impurities removed. For other salt forms of 8-CPT-cAMP please inquire. Lipophilic activator of both cAMP- and cGMP-dependent protein kinase and of Epac. Higher activation potential compared to cAMP; excellent cell membrane permeability, improved phosphodiesterase stability and high site selectivity preferring site B of cAK type II. Detailed technical information and selected references available. Reference: Geiger et al.: Proc. Natl. Acad. Sci. USA, 89, 1031 - 1035 (1992). Caution: Despite its name this analogue is not selective, but activates cGMP-dependent protein kinase as well! In addition, it increases the basal cGMP level by inhibition of PDE V (Murray et al., Biochem. Pharmacol., 44, 2303 - 2306 (1992)). 8-CPT-cAMP is also available in an inexpensive normal quality form ( C 010 Economy Grade ). Potential metabolites such as 8-pCPT-5'-AMP (Cat. No. C 101) and 8-pCPT-Adenosine (Cat. No. C 086) are also offered.
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