8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate ( 8-pCPT-cGMP ), economy grade

Membrane-permeant PKG agonist
Cat. No.: C 009 E   CAS No.: [51239-26-0]   Bulk available
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C16H14ClN5O7PS•Na; MW 509.8 (anhydrous basis); λmax 276 nm; ε 21500; sodium salt, purity > 97% HPLC. For other salt forms please inquire. This product corresponds to normal quality offered elsewhere. If fluorescent impurities disturb your assay, a specially purified quality is available as well (C 009 Fluorescence Grade). Selective activator of both, cGMP-dependent protein kinase type I α and type II, as well as of cGMP-gated ion channels. Higher activation potential compared to cGMP; excellent cell membrane permeability and stability towards many phosphodiesterases. Recommendable alternative to unsuitable analogues such as dibutyryl cGMP. Detailed technical information and updated reference list available on request. Reference: Geiger et al., Proc. Natl. Acad. Sci. USA, 89, 1031 - 1035 (1992).

 



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