Basket (0 Items) - Amount: 0.00$8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, acetoxymethyl ester ( Sp-8-Br-cAMPS-AM )
Metabolically activatable prodrug form of the PDE-resistant PKA activator Sp-8-Br-cAMPS
Cat. No.: B 029 CAS No.: [pending]
C13H15BrN5O7PS; MW 496.2; λmax 264 nm; ε 17000. Purity > 97% HPLC for mixture of the axial and equatorial isomer. Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-8-Br-cAMPS (Cat. No. B 002). Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some 8-Br-cAMP as well. Detailed technical information available. Compare: Maronde et al., J. Pineal Res., 31, 183 - 185 (2001).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI
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