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Equatorial isomer. BCMCM-caged 8-Br-cAMP is an only weakly fluorescent, caged precursor of 8-bromo cyclic cAMP, which upon irradiation, releases both 8-Br-cAMP and a fluorescent coumarin analogue. Excellent solubility in water or buffers. Detailed technical information available. Reference: Hagen et al., Angew. Chem. Int. Ed., 40, 1045 - 1048 (2001).
| Cat. No. | B 018 |
| CAS number | [370091-64-8] |
| Purity | > 98% HPLC |
| Storage temperature | -20°C / -4°F |
| Light-sensitive | True |
| Molecular formula | C₂₄H₂₁BrN₅O₁₄P x 2.5 H₂O |
| Molecular weight [g/mol] | 759.4 |
| Modifications | 8-cAMP |
| Target | PKA (cAK) Activator |
| Absorption max [nm] | 346 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 10300 |
- 1. Hagen V., Benndorf K.Kaupp U. B., aus: Dynamic Studies in Biology - Phototriggers R. Givens) Wiley-VCH Verlag Weinheim, 0, 0 - 0 (2005), "Photochemical Release of Second Messengers - Caged Cyclic Nucleotides"
- 2. Kaupp U. B.Seifert R., Physiol. Rev., 82, 769 - 824 (2002), "Cyclic Nucleotide-Gated Ion Channels"
- 3. Hagen V., Kaupp U. B., Bendig J.Wiesner B., Deutsche Offenlegungsschrift of 20.04.2000, 0, 0 - 0 (2000), "Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung"
