8- Bromoguanosine- 3', 5'- cyclic monophosphate ( 8-Br-cGMP ), economy grade
PKG agonist
C10H10BrN5O7P•Na; MW 446.1; λmax 260 nm; ε 16200; sodium salt, typical purity approx. 98% HPLC. This product corresponds to normal quality offered elsewhere. If fluorescent impurities disturb your assay, a specially purified quality is available ( B 004 Fluorescence Grade ) with a purity > 99% HPLC. For other salt forms or metabolites of 8-Br-cGMP please inquire. Activator of cGMP-dependent protein kinases I α, I ß & type II and cGMP-gated ion channels (cyclic GMP agonist). Increased metabolical stability compared to cGMP, but not completely stable as often stated. 8-pCPT-cGMP (Cat. No. C 009), a highly membrane-permeant and metabolically resistant cGMP-agonist seems to be superior for most applications. Detailed technical information and reference list available. Reference: Rapoport et al., Proc. Natl. Acad. Sci. USA, 79, 6470 - 6474 (1982).
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