We are pleased to welcome our new distribution partners:

• Annoron (Beijing) Biotechnology - China
• GenoChem World SL - Spain
• Sungwoo Life Science Inc - Republic of Korea

Please find their contact details here.

BIOLOG sponsors the 11th International Conference on cGMP which will take place in Lübeck, Germany, June 28-30, 2024.

The conference series remains one of the leaders in the field and will address broadly, and at the highest international scientific level, cGMP generators and effectors as well as their pathophysiological and pharmacological implications. Sessions will be led by invited presenters and speakers selected from submitted abstracts. Exciting and largely unpublished basic science and clinical advances will be presented.

For further information please click here.

Our product line of ADPR analogues has been expanded by another product. Please follow the links below to visit the corresponding product detail pages:

• 2'-pRib-AMP (Cat. No. P 128) - isomeric analogue of the natural signal molecule ADPR and monomeric metabolite of poly(ADP-ribose) (PAR), can be used to detect and analyse PAR-specific binding properties of poly(ADP-ribose) polymerases

For a list of all ADPR and cADPR analogues available from Biolog please click here.

We have added two alkyne-containing products for Click Chemistry Applications to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

8-Bu(3-yne)T-Ado (Cat. No. B 284) - alkyne-containing analogue of adenosine

8-Bu(3-yne)T-ATP (Cat. No. B 302) - alkyne-containing analogue of ATP

These alkyne-containing analogues are a suitable molecular tool for the copper-catalysed Huisgen azide-alkyne [3+2] cycloaddition (CuAAC), which has attracted particular interest for the introduction of reporter groups and for the labelling of various biomolecules like adenosin- or ATP-binding proteins by the so-called click-chemistry technique.

We have added four new azide-containing analogues of dNTPs for Click Chemistry Applications to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

• 5-N₃Ac-AA-dUTP - Cat. No. A 358
• 7-N₃Ac-AParg-7-C-dATP - Cat. No. A 383
• 5-N₃Ac-AA-dCTP - Cat. No. A 385
• 7-N₃Ac-AParg-7-C-dGTP - Cat. No. A 392

These analogues are a suitable molecular tool for the copper(I)-catalysed Huisgen azide-alkyne [3+2] cycloaddition (CuAAC) or copper(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC) with strained alkynes, respectively.

We have added two new isotope-labelled cyclic dinucleotides to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

• [¹⁵N₁₀]-c-diAMP (Cat. No. C 409) - Stable isotope version of the bacterial second messenger c-diAMP (Cat. No. C 088)
• [¹³C₂₀,¹⁵N₁₀]-c[G(2',5')pA(3',5')p] (Cat. No. C 410) - Stable isotope version of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] / 2'3'-cGAMP (Cat. No. C 161)

These products are suitable as internal standards in LC-MS applications.

We have added two new nucleoside bisphosphates and two cyclic oligoadenylates to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

Nucleoside bisphosphates: Phosphate groups are attached to ribose 2' or 3' position and the ribose 5' position of adenosine

• pA-3'-p (Cat. No. A 444) - Product of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a cofactor of sulfotransferases (ST / SULTs), can be used to study the kinetic properties and structure of sulfotransferases
• pA-2'-p (Cat. No. A 449) - Inhibitor of P2Y₁, exhibits non-selective antagonism at platelet P2X₁ receptors

Cyclic oligoadenylates: Analogues of c-tetraAMP (Cat. No. C 335) with modifications in all ribose 2'-positions

• 2',2'',2''',2''''-Tetra-O-Me-c-tetraAMP (Cat. No. T 066) - O-methyl modifications are expected to make the compound resistant to degradation by nucleases
• 2',2'',2''',2''''-Tetra-c-tetradAMP  (Cat. No. T 070) - Deoxy modifications are expected to make the compound resistant to degradation by nucleases

The entire Biolog team wishes you a healthy and successful New Year! We look forward to working with you in 2024.

Das gesamte Biolog-Team wünscht Ihnen ein gesundes und erfolgreiches neues Jahr! Wir freuen uns auf die Zusammenarbeit mit Ihnen im Jahr 2024.

We have added a new dinucleoside monophosphate and three new linear RNA dinucleotides to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

• GpA (Cat. No. G 040), can be useful in kinetic studies on RNA polymerases or ribonucleases and is a metabolite of the linear RNA dinucleotides pGpA (Cat. No. P 120) and GpAp (Cat. No. G 056). 

• ApAp (Cat. No. A 261) is a potential metabolite of 3'-polyadenylated messenger RNA.
• GpGp (Cat. No. G 057) has very low binding affinity to the c-di-GMP-I riboswitch.
• pGpA (Cat. No. P 120) is structurally related to the 3'3'-cGAMP degradation product pApG (Cat. No. P 082), generated by specific PDEs in Vibrio cholerae.

Our product line of cyclic nucleotides has been expanded by 2 new products. Please follow the links below to visit the corresponding product detail pages:

• 2'-AHC-cUMP (Cat. No. A 162), Analogue of cUMP (Cat. No. U 001), suitable as a ligand for affinity chromatography of cUMP binding proteins or for coupling of various labelling structures including fluorophores

• 2'-AHC-cUMP-Agarose (Cat. No. A 164), 2'-AHC-cUMP immobilized on agarose gel, can be used for affinity chromatography of cUMP-responsive proteins, such as protein kinases, phosphodiesterases and others

Biolog sponsors the Biochemical Society Event "AKAP2023: 7th International Meeting on Anchored cAMP signalling Pathways" which will take place 27-29 September 2023 in London/UK.

Please follow the link to visit the meeting's homepage.

Our product catalogue has been expanded by 3 nucleotide sugars. Please follow the links below to visit the corresponding product detail pages:

• CMP-Neu5Ac (Cat. No. C 408), donor substrate for eukaryotic and prokaryotic sialyltransferases (SiaTs) and essential substrate for SiaTs in the synthesis of glycoconjugates

• GDP-Fuc (Cat. No. G 069), donor substrate for eukaryotic (FUT) and prokaryotic fucosyltransferases (FucT), which are utilized for in vitro glycoengineering of biopharmaceutical glycoproteins and cell surface glycans

• UDP-GalNAc (Cat. No. U 027), donor substrate for eukaryotic and prokaryotic N-acetylgalactosaminyltransferases (GalNAcTs) involved in mucin, glycosphingolipid, and glycosaminoglycan synthesis

For a list of all new products please click here.

Our product line of cADPR analogues has been expanded by 2 new glycocyclic cADPR products, which were structurally identified and resolved in 2 recent studies in 2022. Both are regioisomers of the canonical second messenger cADPR (Cat. No. C 005). Please follow the links below to visit the corresponding product detail pages:

• 3'-cADPR (Cat. No. C 404), novel signaling molecule involved in the innate immunity in plants and bacteria

• 2'-cADPR (Cat. No. C 406), identified in Toll/interleukin-1 receptor (TIR)-domain containing proteins in plants and bacteria, and it is hypothesized to have a role in immune signaling

An introduction into glycocyclic cADPR isomers written by Allen Lu and Philip Kranzusch - Harvard Medical School, Dana-Farber Cancer Institute - can be found here.

For a list of all cADPR analogues available from Biolog please click here.

Our product line of cyclic nucleotides has been expanded by 4 new products, three 2',3'-cyclic nucleotides and one 3',5'-cyclic nucleotide. Please follow the links below to visit the corresponding product detail pages:

• 2',3'-cCMP (Cat. No. C 104), structurally related to the naturally occurring 2',3'-cNMPs 2',3'-cAMP (Cat. No. A 307), 2',3'-cGMP (Cat. No. G 025), 2',3'-cIMP (Cat. No. I 032) and 2',3'-cUMP (Cat. No. U 004), detected in eukaryotes and prokaryotes

• Rp-2',3'-cGMPS (Cat. No. G 070) and its corresponding Sp-isomer Sp-2',3'-cGMPS (Cat. No. G 071), valuable tools for determination of the stereochemical requirements of 2',3'-cGMP binding receptors

• MANT-cUMP (Cat. No. M 068) - Fluorescent, membrane-permeant analogue of cUMP (Cat. No. U 001), useful in phosphodiesterase studies

For a list of all cyclic nucleotides available from Biolog please click here.

Two new hybrid purine-pyrimidine cyclic dinucleotides have been added to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

• c[U(2',5')pA(3',5')p] (2',5'-3',5'-cUAMP or 2'3'-cUA, Cat. No. C 399) is a second messenger which was found to be biosynthesized in bacteria and oyster species, respectively. In Crassostrea virginica, c[U(2',5')pA(3',5')p] induced a gene expression pattern strongly associated with innate immunity, including upregulated expression of genes encoding transcription factors (NF-kB, IRFs, and STATs), immune receptors (NLRs, RLRs, cGLRs, and STING), and proteins with homology to human interleukins and inhibitor of apoptosis (IAP) factors. Li et al., Cell (2023), https://doi.org/10.1016/j.cell.2023.05.038. 

• c[A(2',5')pU(3',5')p] (2',5'-3',5'-cAUMP, Cat. No. C 398) is a stereoisomer of the second messengers c-(ApUp) (Cat. No. C 357) and c[U(2',5')pA(3',5')p] (Cat. No. C 399).

Biolog sponsors the DynIon International Symposium which will take place at the Friedrich Schiller University Jena, Germany, 15-17 June 2023.

The International Symposium on functional dynamics of ion channels and transporters is organised by the DFG Research Unit 2518 'DynIon'. The symposium will cover topics on the biophysics of ion channels, including ion permeation, ligand and substrate binding, translocation, and voltage- or ligand-dependent modification of function.
The symposium will bring together experienced scientists and young researchers from experimental and computational fields.

For further information please click here. 

We have added one functionalized analogue of FAD and three reactive nucleoside analogues to our product catalogue. Please follow the links below to visit the corresponding product detail pages:

6-CP-FAD (Cat. No. F 017) is a functionalized analogue of the adenine-containing enzymatic redox cofactor flavin adenine dinucleotide (FAD). The terminal carboxy group of 6-CP-FAD can be used for coupling of various labels, dyes or supports with free amino groups. Via its corresponding succinimidyl ester, 6-CP-FAD can also be coupled to FAD-binding apo-proteins

Reactive nucleoside analogues, where the hydroxy group in 3'- or 5'-position has been replaced by a reactive azido group
5'-N₃-Guo - Cat. No. A 079 - Reactive guanosine analogue
3'-N₃-Ado - Cat. No. A 243 - Reactive adenosine analogue
3'-N₃-Guo - Cat. No. A 244 - Reactive guanosine analogue 

Two new dinucleotides have been added to our product catalogue. In both the 5'-ATP unit is connected via a 2' → 5' linkage with a 5'-NMP to form a linear dinucleotide. Please follow the links below to visit the corresponding product detail pages:

pppA(2',5')pA (Cat. No. T 073) is considered to be a linear intermediate in the enzymatic production of 2' →  5'-linked oligoadenylates by oligoadenylate synthase 1 (OAS1). Hornung et al., Nat. Rev. Immunol., 14, 521 - 528 (2014).

pppA(2',5')pG (Cat. No. T 074) is the linear intermediate in the two-step enzymatic production of 3',2'-cGAMP (Cat. No. C 238) by the Drosophila melanogaster enzyme cGLR1 in response to dsRNA. Slavik et al., Nature, 597, 109 - 113 (2021).

Our product line of 5'-triphosphates has been expanded by 4 new products. Please follow the links below to visit the corresponding product detail pages:

• ATP analogues, useful for research into ATP-dependent receptor proteins and for determination of their stereospecificity

Sp-ITP-α-S - Cat. No. I 026
Rp-ITP-α-S - Cat. No. I 027

• Nucleobase-modified GTP analogue, useful for research into GTP-dependent receptor proteins, such as receptor mapping studies

1-Bn-GTP - Cat. No. B 222

• Analogue and potential metabolite of 2-MeS-ATP (Cat. No. M 021), potential P2Y purinoceptor agonist

2-MeS-ITP - Cat. No. M 114 

For a list of all 5'-triphosphates available from Biolog please click here.

All new products  can be found here.

BIOLOG sponsors the EMBO workshop "The Immune System of Bacteria" which will take place in Rehovot, Israel, February 28 - March 03 , 2023.

The purpose of the 2023 Symposium on the Immune System of Bacteria is to bring together the emerging community of researchers studying “beyond CRISPR” aspects of bacterial immunity. Topics that will be covered include defense systems such as CBASS, prokaryotic argonautes, retrons, chemical defense systems, and other new systems, as well as defense island biology and evolutionary aspects of bacterial immunity.

The program will comprise talks from invited speakers, as well as short talks selected from submitted abstracts.

For further information please click here.

Our product line of 5'-triphosphates has been expanded by 8 new products. Please follow the links below to visit the corresponding product detail pages:

Triphospates, supposed to have increased metabolic stability compared to their parent compounds dGTP, dUTP, dCTP:

• Rp-2'-F-dGTP-α-S - Cat.No. D 231
• Sp-2'-F-dGTP-α-S - Cat.No. D 232
• Rp-2'-F-dUTP-α-S - Cat.No. D 234
• Sp-2'-F-dUTP-α-S - Cat.No. D 235
• Rp-2'-F-dCTP-α-S - Cat.No. D 252
• Sp-2'-F-dCTP-α-S - Cat.No. D 253

Ribose-modified analogues of GTP / dGTP, mirror image versions of naturally occurring β-D-GTP / β-D-dGTP:

• β-L-GTP   - Cat.No. G 030
• β-L-dGTP - Cat.No. G 037

For a list of all 5'-triphosphates available from Biolog please click here.

All new products can be found here.

Our product line of 5'-triphosphates has been expanded by 3 new products. Please follow the links below to visit the corresponding product detail pages:

• ANT-dGTP (Cat. No. A 222) - Fluorescent dGTP analogue, potential inhibitor of various adenylyl cyclase isoforms

• 2-Cl-ITP (Cat. No. C 158) - Putative P2Y purinoceptor agonist and inhibitor of soluble guanylate cyclase

• 3'-O-MS-dATP (Cat. No. D 167 T) - dATP analogue, suitable for coupling of various ligands including reporter groups

For a list of all 5'-triphosphates available from Biolog please click here.

All new products  you find here.

Our product line of 2',3'-cyclic nucleotides has been expanded by

• 5'-O-MB-2',3'-cAMP (Cat. No. M 176)

5'-O-MB-2',3'-cAMP is a membrane permeable analogue and prodrug / precursor of 2',3'-cAMP (Cat. No. A 307). For a complete list of 2',3'-cyclic nucleotides offered by Biolog please click here.

Furthermore, we have expanded our product line of NAD analogues by

• carba-NAD⁺ (Cat. No. C 403)

carba-NAD⁺ is a NAD⁺ mimic with improved hydrolytic stability against adenosine diphosphate ribosyl transferase (ART) enzymes and NAD glycohydrolases. For a complete list of NAD analogues offered by Biolog please click here.

For a list of all new products please click here.

We are pleased to announce that Biolog's quality management system has been re-certified to the ISO 9001:2015 standard. Please click here to download a PDF of our updated certificate.

Our product line of 5'-triphosphates has been expanded by ten new products.

All these products are potential inhibitors of various adenylyl cyclase isoforms and soluble guanylyl cyclase (sGC). Please follow the links below to visit the corresponding product detail pages:

Ribose-modified GTP analogues:

• 2'-O-Bn-GTP - Cat. No. B 183
• 3'-O-Bn-GTP - Cat. No. B 193

Fluorescent triphosphates:

• Br-ANT-ITP - Cat. No. B 118
• Br-ANT-dATP - Cat. No. B 145
• Br-ANT-dGTP - Cat. No. B 151
• Br-ANT-GTP - Cat. No. B 152
• 2'-O-Bn-3'-MANT-GTP - Cat. No. B 187
• Cl-ANT-dATP - Cat. No. C 142
• Cl-ANT-dGTP - Cat. No. C 151
• Cl-ANT-GTP - Cat. No. C 152

For a list of all 5'-triphosphates available from Biolog please click here.

Our product line of cyclic nucleotides has been expanded by two new Nitro-cyclic monophosphates:

• 8-NO₂-cGMP (8-Nitro-cGMP, Cat. No. N 011)  
• 8-NO₂-cXMP (8-Nitro-cXMP, Cat. No. N 060)

The nitrated derivative of cGMP, 8-NO₂-cGMP, is considered to play an important role in NO-mediated signal transduction. 8-NO₂-cXMP is structurally related to and a potential metabolite of 8-NO₂-cGMP.

BIOLOG sponsors the 10th International Conference on cGMP which will take place in Augsburg, Germany, June 17-19, 2022.

The conference series remains one of the leaders in the field and will address broadly, and at the highest international scientific level, cGMP generators and effectors as well as their pathophysiological and pharmacological implications. Sessions will be led by invited presenters and speakers selected from submitted abstracts. Exciting and largely unpublished basic science and clinical advances will be presented.

For further information please click here.

We are pleased to welcome our new distribution partners in China:

Bioinborn Scientific INC - Wuhan City, P.R. China
Shanghai BioLeaf Biotech Co., Ltd - Shanghai, P.R. China 

Please find their contact details here.

We are pleased to announce that we have established a distribution agreement with BTL Biotechno Labs Pvt Ltd in New Delhi, India. Please find their full contact details here.

Our product line of cyclic nucleotides has been expanded by a number of new 2',3'-cyclic nucleotides:

• 5'-AHC-2',3'-cAMP - Cat. No. A 327
• 5'-AHC-2',3'-cAMP-Agarose - Cat. No. A 329
• 5'-Biotin-9-2',3'-cAMP - Cat. No. B 267
• Sp-8-Br-2',3'-cAMPS - Cat. No. B 268
• 8-Br-2',3'-cGMP - Cat. No. B 292
• 2',3'-cIMP - Cat. No. I 032 

For a list of all 2',3'-cNMPs available from Biolog please click here.

We have added β-Benzamide adenine dinucleotide (BAD) to our product line of β-NAD⁺ analogues. It is offered under catalog number B 301.

BAD is the biologically active metabolite of benzamide riboside and has improved stability compared to β-NAD⁺. Further information can be found on the product detail page of Cat. No. B 301.

Biolog now offers two isomeric di-thiophosphate derivatives of the recently discovered nucleotide second messenger 3'2'-cGAMP (syn. c[A(2',5')pG(3',5')p]), Cat. No. C 238). The di-thiophosphate modifications are expected to render the compounds resistant to degradation by 3'2'-cGAMP hydrolysing enzymes.

Please follow the links below to visit the corresponding product detail pages:

• Cat. No.: C 246 - c[A(2',5')pS-G(3',5')pS], isomer 1 / 3'2'-cGAMPSS, isomer 1
• Cat. No.: C 247 - c[A(2',5')pS-G(3',5')pS], isomer 2 / 3'2'-cGAMPSS, isomer 2.

3'2'-cGAMP (syn. c[A(2',5')pG(3',5')p]) which is offered by Biolog under Cat. No. C 238, is a cyclic dinucleotide that was found to be biosynthesized by the Drosophila melanogaster enzyme cGLR1 in response to dsRNA.

A brief review written by Kailey Slavik and Philip Kranzusch (Harvard Medical School - Dana-Farber Cancer Institute) gives an overview of the recent findings regarding this compound (download PDF).

The cyclic oligoadenylate c-pentaAMP (Cat. No. C 394) has become available from Biolog. Please visit the product detail page for further information.

Our product line of cyclic oligoadenylates has been expanded by another two new products which are biotinylated versions of the bacterial second messenger c-tetraAMP (Cat. No. C 335) with different spacer lengths:

• 2'-Biotin-16-c-tetraAMP - Cat. No. B 290
• 2'-Biotin-49-c-tetraAMP - Cat. No. B 295.

Our product line of cyclic oligoadenylates has been expanded by two new products:

• 2',2'',2''',2''''-Tetra-F-c-tetradAMP - Cat. No. T 062
• 2',2'',2'''-Tri-F-c-tridAMP - Cat. No. T 064

These compounds are fluorinated versions of the bacterial second messengers c-tetraAMP (Cat. No. C 335) and c-triAMP (Cat. No. C 362), respectively, which are expected to have increased metabolic stability.

The extensive measures taken at Biolog in March 2020 to protect against the spread of COVID-19 enable us now to ensure smooth continuation of all processes despite the renewed lockdown in Germany. We are still available for you, all incoming inquiries and orders will still be processed quickly and reliably, as usual.

Please contact us with any questions or concerns.

The cyclic nucleotides 8-[Alexa Fluor® 488]-AHA-cAMP (Cat. No. A 412) and 8-Azido-cGMP (Cat. No. A 047) have been added to our product line of cAMP and cGMP analogues.

8-[Alexa Fluor® 488]-AHA-cAMP is a fluorescently labelled analogue of cAMP, and 8-Azido-cGMP can be used for photoaffinity labelling of cGMP binding proteins.

We have expanded our product lines of cyclic dinucleotides and cyclic oligonucleotides by three new products:

The cyclic oligonucleotide 2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP (cFA6, Cat. No. H 038) is a fluorinated version of the bacterial second messenger c-hexaAMP (Cat. No.: C 332) with increased metabolic stability.

The cyclic dinucleotides c-(GpUp) (cGMP-UMP, Cat. No. C 371) and c-(CpUp) (cCMP-UMP, Cat. No. C 375) have been found to be biosynthesized by alternative bacterial cyclic dinucleotide synthases (Whiteley et al., Nature, 567, 194 - 199 (2019)).

The latest additions to our product lines of cyclic dinucleotides, nucleoside-5'-O-monophosphates and nucleoside-5'-O-triphosphates are:

• c[A(2',5')pG(3',5')p] / 3'2'-cGAMP - Cat. No. C 238
• c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] - Cat. No. C 270 (fluorescently labelled 2'3'-cGAMP)
• c[G(2',5')p-2'-[sCya5]-AHC-A(3',5')p] - Cat. No. C 271 (fluorescently labelled 2'3'-cGAMP)
• c[3'-[DY-547P1]-AHC-G(2',5')pA(3',5')p] - Cat. No. C 352 (fluorescently labelled 2'3'-cGAMP)
• c[G(2',5')p-2'-[DY-547P1]-AHC-A(3',5')p] - Cat. No. C 353 (fluorescently labelled 2'3'-cGAMP)
• 3'-NH₂-5'-AMP - Cat. No. A 306
• 2-AHT-ATP - Cat. No. A 260

For a list of all new products please click here.

Biolog Life Science Institute has taken all possible preventative measures to maintain internal processes and prevent further spread of COVID-19. Incoming orders are processed quickly and reliably as usual, and the work on custom syntheses and projects continues. We are available for you during our normal office hours.

We ask our customers, partners and suppliers to inform us as early as possible of any changes that could affect the joint business.

Please contact us with any questions or concerns.

 We have expanded our new product line of cyclic oligonucleotides by three new compounds:

We would like to thank all our customers, partners, and friends for the good and pleasant cooperation in 2019.

The whole Biolog Team wishes you a healthy and successful New Year!

___________________________________________________

Wir möchten uns bei allen Kunden, Geschäftspartnern und Freunden für die gute und angenehme Zusammenarbeit im Jahr 2019 bedanken.

Das gesamte Biolog Team wünscht Ihnen ein gesundes und erfolgreiches Neues Jahr!

Biolog is one of the sponsors of the "Nanodomains in cyclic nucleotide signalling: from mechanisms to therapeutic approaches" meeting which will be held at the Imperial College London, UK, September 16-18, 2019.

This meeting gathers renowned experts who will highlight recent advances in understanding the molecular mechanisms underlying cAMP signalling in nano-scale compartments and how such local signalling regulates key cellular and physiological processes in the cardiovascular system. A further focus will be the relevance of cAMP signalling compartments as pharmacological targets for the treatment of cardiovascular diseases. Cutting-edge methodology such as the use of various high-resolution imaging techniques and advanced biosensors, animal models, and the current state of drug development, will be discussed.

For further information please follow the link to the meeting's website.

We are pleased to announce an important change at Biolog:

The operative business of BIOLOG Life Science Institute Forschungslabor und Biochemica-Vertrieb GmbH has been transferred to the newly founded Biolog Life Science Institute GmbH & Co. KG. The founder and General Manager of BIOLOG, Dr. Hans-Gottfried Genieser, is retiring after almost thirty years of business activity and will hand over the management to his long-time employees Andrea Intemann and Dr. Frank Schwede. An official information from the new management is available for download.

The Biolog team will continue to be available to you as a qualified and reliable business partner at the known telephone numbers and e-mail addresses.
We look forward to the continued successful cooperation with all customers and partners.
___________________________________________________

Wir freuen uns, Ihnen eine wichtige Änderung bei Biolog mitteilen zu können:

Im Zuge der Altersnachfolge wurde das operative Geschäft der BIOLOG Life Science Institute Forschungslabor und Biochemica-Vertrieb GmbH auf die neu gegründete Biolog Life Science Institute GmbH & Co. KG ausgegliedert. Der Firmengründer und bisherige Geschäftsführer, Herr Dr. Hans-Gottfried Genieser, begibt sich damit nach fast dreißigjähriger Geschäftstätigkeit in den Ruhestand und übergibt die Geschäftsführung an seine langjährigen Mitarbeiter Andrea Intemann und Dr. Frank Schwede. Eine offizielle Mitteilung der neuen Geschäftsführung kann hier eingesehen werden.

Das Biolog Team steht Ihnen auch weiterhin als qualifizierter und zuverlässiger Geschäftspartner unter den bekannten Rufnummern und E-Mail-Adressen zur Verfügung.
Wir freuen uns auf die weiterhin erfolgreiche Zusammenarbeit mit all unseren Kunden und Partnern.

We have added four new polymer-linked dimeric (PLD) cGMP analogues to our product portfolio which contain two cGMP moieties linked by polymer chains of different lengths:

• cGMP-8-T-(EO)₅-ET-8-cGMP • Cat. No. G 031

• cGMP-8-TMAmd-(PEG pd 2000)-AmdMT-8-cGMP  • Cat. No. G 043

• PET-cGMP-8-TMAmd-(EO)₈-EAmdMT-8-cGMP-PET • Cat. No. P 054

• PET-cGMP-8-TMAmd-(PEG pd 2000)-AmdMT-8-cGMP-PET • Cat. No. P 059

These membrane-permeant cGMP dimers exhibit enhanced PKG activation properties by addressing two binding sites simultaneously with a single molecule.

8-(3-Butynylthio)guanosine-3',5'-cyclic monophosphate (8-Bu(3-yne)T-cGMP, Cat. No. B 185) can be used for copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click chemistry" reactions with azide-containing molecules.

8-Fluo-AET-c-diAMP • Cat. No. F 014

isoGDP • Cat. No. I 038

isoGTP • Cat. No. I 039

ε-Ap₄A / ε-AppppA • Cat. No. E 029

ε-Ap₄-ε-A / ε-Apppp-ε-A • Cat. No. E 030

Latest additions to our product catalogue are

1) c-triAMP (cyclic triadenylate or c-A3) • Cat. No. C 362

Reference: Kazlauskiene et al., Science, 357, 605-609 (2017): "A Cyclic Oligonucleotide Signaling Pathway in Type III CRISPR-Cas Systems"

2) c-(ApUp) (cUMP-AMP or cUA) • Cat. No. C 357

Reference: Whiteley et al., Nature, 567, 194-199 (2019): "Bacterial cGAS-like Enzymes Synthesize Diverse Nucleotide Signals"

Following nucleoside-5'-O-triphosphates are now available as well:

• 3'- O- Acetyl- 2'- deoxyadenosine- 5'- O- triphosphate ( 3'-O-Ac-dATP ), Cat. No. A 276

• 3'- O- Acetyl- 2'- deoxycytidine- 5'- O- triphosphate ( 3'-O-Ac-dCTP ), Cat. No. A 277

• 3'- O- Acetyl- 2'- deoxyguanosine- 5'- O- triphosphate ( 3'-O-Ac-dGTP ), Cat. No. A 278

• 3'- O- Acetylthymidine- 5'- O- triphosphate ( 3'-O-Ac-TTP / 3'-O-Ac-dTTP ), Cat. No. A 279

• Isoguanosine- 5'- O- triphosphate ( isoGTP ), Cat. No. I 039

We have added eight novel cyclic dinucleotides to our continuously expanding product line:

• Cyclic (cytidine monophosphate- guanosine monophosphate) ( c-(CpGp) / c[C(3',5')pG(3',5')p] ), Cat. No. C 199

• Cyclic dicytidine monophosphate ( c-diCMP ), Cat. No. C 200

• Cyclic diuridine monophosphate ( c-diUMP ), Cat. No. C 256

• Cyclic (3'- O- (N'- methylanthraniloyl)guanosine- (2' −> 5')- monophosphate- 2'- O- (N'- methylanthraniloyl)adenosine- (3' −> 5')- monophosphate) ( c[3'-MANT-G(2',5')p-2'-MANT-A(3',5')p] / Di-MANT-2'3'-cGAMP ), Cat. No. C 284

• Cyclic (3'- O- (N'- methylanthraniloyl)guanosine- (2' −> 5')- monophosphate- adenosine- (3' −> 5')- monophosphate) ( c[3'-MANT-G(2',5')pA(3',5')p] ), Cat. No. C 300

• 2'- Deoxy- 2''- O- methyl- cyclic diguanosine monophosphate ( c-di-2'-d-2''-O-Me-GMP / c-(2'-dGp-2'-O-Me-Gp) ), Cat. No. D 142

• 2'- , 2''- Dideoxy- 2'-, 2''- difluoro- cyclic diguanosine monophosphate ( 2',2''-Di-F-c-didGMP ), Cat. No. D 210

• 2'- O- (6- [mPEG(11)]aminohexylcarbamoyl)- cyclic diguanosine monophosphate ( 2'-[mPEG(11)]-AHC-c-diGMP ), Cat. No. M 073

We have added isotope labelled [¹³C₂₀,¹⁵N₁₀]-c-diGMP (Cat. No. C 183) to our continuously expanding product line of cyclic dinucleotides.

[¹³C₂₀,¹⁵N₁₀]-c-diGMP is useful as an internal standard for the detection and quantification of the bacterial signalling nucleotide c-diGMP in bacterial extract samples by LC-MS/MS analysis.

For further information on the [¹³C₂₀,¹⁵N₁₀]-c-diGMP please view the corresponding product detail page.

BIOLOG sponsors the upcoming annual Conference 2019 of the Association for General and Applied Microbiology (VAAM 2019) which will take place in Mainz, Germany, March 17-20, 2019, and the bi-annual FASEB Science Research Conference on NAD⁺ Metabolism and Signaling to be held in Dublin, Ireland, June 23-28, 2019.

We are pleased to announce a significant price reduction for our product Rp,Rp-2'3'-c-diAMPSS (syn. c[A(2',5')pS[Rp]-A(3',5')pS[Rp]], Cat. No. C 224). Please follow the link to the product detail page for further information.

Rp,Rp-2'3'-c-diAMPSS is a synthetic cyclic dinucleotide with improved stability against degradation by phosphodiesterases and enhanced binding affinity to STING. The related structure c[A(2',5')pS[Sp]-A(3',5')pS[Rp]], Cat. No. C 223 is also available.

Cyclic oligoadenylates such as c-tetraAMP were found to be novel bacterial second messengers involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements in many prokaryotes. References: Kazlauskiene et al., Science, 357, 605 - 609 (2017); Niewoehner et al., Nature, 548, 543 - 548 (2017).

"Future Products" list structures which are nearly ready for commercialisation. The list will be permanently updated and contains already > 80 items at the moment.

pppG(2',5')pA  is  considered  to  be  the  linear  catalytic  intermediate  in  the  enzymatic  production  of  2',3' - cGAMP  (aka c[G(2',5')pA(3',5')p], BIOLOG Cat. No. C 161) by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). According to  Hall e t al. (2017)  human  stimulator of interferon genes STING _{155 - 341} does not bind pppG(2',5')pA at concentrations of up to 50 μM.

In pppApG a 5'-ATP unit is connected with a 5'-GMP unit via a 3' → 5' linkage to form a linear dinucleotide. pppApG is a potential endogenous metabolite of the metazoan second messenger 2',3'-cGAMP (c[G(2',5')pA(3',5')p], Cat. No. C 161) and/or of the bacterial signalling nucleotide 3'3'-cGAMP (c-(ApGp), Cat. No. C 117). Kranzusch et al. (2014) reported pppApG to be the linear dinucleotide intermediate in the enzymatic production of 3',3'-cGAMP by the Vibrio cholerae pathogenicity factor DncV. References: Kranzusch, P.J. et al., Cell, 158, 1011 - 1021 (2014); Deng, T. et al., J. Virol., 80, 2337 - 2348 (2006).

With Rp-2'-F-dATP-α-S (Cat. No. D 220) and Sp-2'-F-dATP-a-S (Cat. No. D 219) the sulfur-modified analogues of 2'-deoxy-2'-fluoro-ATP (Cat. No. D 074), which are considered to be metabolically more stable, have been added to our product list. In addition, c[3'-[sCya7]-AHC-G(2',5')pA(3',5')p], (Cat. No. C 240), a new NIR fluorescent 2',3'-cGAMP analogue has joined the cyclic dinucleotide tools set.

8-Br-2',3'-cAMP (Cat. No. B 280) is now available from Biolog. This compound is considered to be a membane-permeable analogue of 2',3'-cAMP (Cat. No. A 307) and was recently used by Kosmacz et al. (2018) to study the role of 2',3'-cAMP in the formation of stress granules in Arabidopsis thaliana (Reference: Kosmacz et al., Plant Physiol., 177, 411 - 421 (2018): "Interaction of 2',3'-cAMP with Rbp47b Plays a Role in Stress Granule Formation").

Biolog now offers the endogenous Transient Receptor Potential Melastatin 2 (TRPM2) channel superagonist and potential novel second messenger 2'-deoxy-ADPR (Reference: Fliegert et al., Nat. Chem. Biol., 13, 1036 - 1044 (2017): "2'-Deoxyadenosine 5'-diphosphoribose is an Endogenous TRPM2 Superagonist").

We have added three new products to our product line of NAD and ADPR analogues:

• 2'-Deoxy-2'-fluoroadenosine-5'-O-diphosphoribose - Cat. No. D 228
• β-Nicotinamide-2'-deoxyadenine dinucleotide - Cat. No. N 065
• β-Nicotinamide-2'-deoxy-2'-fluoroadenine dinucleotide - Cat. No. N 073

Our product DEACM-caged cAMP (Cat. No. D 042) which was temporarily out of stock, is available again. DEACM-caged cAMP is a caged precursor of the second messenger cAMP and releases both cAMP and a fluorescent coumarin analogue upon irradiation.

Biolog is pleased to be one of the sponsors of the upcoming 70^th Annual Meeting of the German Society for Hygiene and Microbiology e. V. (DGHM, February 19-21, 2018, Bochum, Germany, www.dghm-kongress.de) and of the 3^rd German Pharm-Tox Summit (DGPT, February 26-March 1, 2018, Göttingen, Germany, www.gpts-kongress.de).

Biolog's Quality Management System certification has been upgraded to the new ISO 9001:2015 standard. Please click here to download a PDF of our updated certificate.

The newly discovered bacterial second messenger c-hexaAMP (syn.: cyclic hexaadenylate / c-A6 / cA6) is now available from Biolog.
c-hexaAMP was recently reported by Niewoehner et al. (2017) and Kazlauskiene et al. (2017) to be a signalling molecule in prokaryotes, involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements.

References:

• Niewoehner, O.; Garcia-Doval, C.; Rostøl, J.T.; Berk, C.; Schwede, F.; Bigler, L.; Hall, J.; Marraffini, L.A.; Jinek, M., Nature [Epub ahead of print] (2017): "Type III CRISPR-Cas Systems Produce Cyclic Oligoadenylate Second Messengers"
• Kazlauskiene, M.; Kostiuk, G.; Venclovas, Č.; Tamulaitis, G.; Siksnys, V., Science, 357, 605 - 609 (2017): "A Cyclic Oligonucleotide Signaling Pathway in Type III CRISPR-Cas Systems"

We have added a number of new NAD⁺ analogues, mostly modified at the 8-position of the adenine ring, to our product catalogue. Many of these structures are described in a collaborative paper recently published in Science: Gibson et al., Science, 353, 45 - 50 (2016): "Chemical Genetic Discovery of PARP Targets Reveals a Role for PARP-1 in Transcription Elongation".

• Cat. No. N 025 - 8-MA-NAD⁺ (β-Nicotinamide-8-methylaminoadenine dinucleotide)
• Cat. No. N 026 - 8-DMA-NAD⁺ (β-Nicotinamide-8-dimethylaminoadenine dinucleotide)
• Cat. No. N 031 - 8-PIP-NAD⁺ (β-Nicotinamide-8-piperidinoadenine dinucleotide)
• Cat. No. N 032 - 8-PT-NAD⁺ (β-Nicotinamide-8-phenylthioadenine dinucleotide)
• Cat. No. N 033 - 8-pCPT-NAD⁺ (β-Nicotinamide-8-(4-chlorophenylthio)adenine dinucleotide)
• Cat. No. N 036 - 8-BuT-NAD⁺ (β-Nicotinamide-8-butylthioadenine dinucleotide)
• Cat. No. N 037 - 8-cPeT-NAD⁺ (β-Nicotinamide-8-cyclopentylthioadenine dinucleotide)
• Cat. No. N 038 - 8-ET-NAD⁺ (β-Nicotinamide-8-ethylthioadenine dinucleotide)
• Cat. No. N 039 - 8-PrT-NAD⁺ (β-Nicotinamide-8-propylthioadenine dinucleotide)
• Cat. No. N 051 - 6-Parg-NAD⁺ (β-Nicotinamide-N⁶-propargyladenine dinucleotide) - "Clickable" analogue
• Cat. No. N 053 - 8-pN₃-PAcT-NAD⁺ (β-Nicotinamide-8-(4-azidophenacylthio)adenine dinucleotide) - "Clickable" analogue
• Cat. No. N 055 - 8-Bu(3-yne)T-NAD⁺ (β-Nicotinamide-8-(3-butynylthio)adenine dinucleotide) - "Clickable" analogue
• Cat. No. N 057 - 8-oN₃-BT-NAD⁺ (β-Nicotinamide-8-(2-azidobenzylthio)adenine dinucleotide) - "Clickable" analogue

Biolog is one of the sponsors of the upcoming 8th International Conference on cGMP - cGMP: Generators, Effectors and Therapeutic Implications. The conference will take place June 23-25, 2017 in Bamberg, Germany.

Visit the meeting website at www.cyclicgmp.net for further information on this event.

Biolog sponsors Microbiology and Infection 2017, the 5th Joint Conference of the DGHM (German Society for Hygiene and Microbiology) & VAAM (Association for General and Applied Microbiology), which will be held March 5-8, 2017 in Würzburg, Germany.

Visit the meeting website at www.microbiology-infection.de for further information on this event.

Latest additions to our product line of cyclic dinucleotides are:

• c[A(2',5')pS[Sp]-A(3',5')pS[Rp]] - Cat. No. C 223 (Cyclic (adenosine-(2'→5')-monophosphorothioate[Sp]-adenosine-(3'→5')-monophosphorothioate[Rp])
• c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS - Cat. No. C 224 (Cyclic (adenosine-(2'→5')-monophosphorothioate[Rp]-adenosine-(3'→5')-monophosphorothioate[Rp])
• c[G(2',5')p-ε-A(3',5')p] / ε-2'3'-cGAMP - Cat. No. C 225 (Cyclic (guanosine-(2'→5')-monophosphate-1,N⁶-ethenoadenosine-(3'→5')-monophosphate)
• c-(ε-ApGp) / ε-3'3'-cGAMP - Cat. No. C 226 (Cyclic (1,N⁶-ethenoadenosine monophosphate-guanosine monophosphate))

We have added three new products to our broad product line of cyclic nucleotides:

• 2',3'-cAMP - Cat. No. A 307 (Adenosine-2', 3'-cyclic monophosphate)
• 4-MB-cCMP - Cat. No. M 075 (N⁴-Monobutyrylcytidine-3', 5'-cyclic monophosphate)
• 2'-O-MB-cCMP - Cat. No. M 082 (2'-O-Monobutyrylcytidine-3', 5'-cyclic monophosphate)

Biolog sponsors the 20^th Joint Meeting of the Signal Transduction Society (STS) "Signal Transduction – Receptors, Mediators and Genes" which will be held November 9-11, 2016 in Weimar/Germany. Visit the homepage of the Signal Transduction Society at https://sigtrans.de/index.html.

Three new linear dinucleotides have become available from Biolog:

• pApG - Cat. No. P 082: Degradation product of the bacterial second messenger 3'3'-cGAMP (c-(ApGp), Cat. No. C 117)
• pG(2',5')pA - Cat. No. P 081: Potential degradation product of the metazoan second messenger 2'3'-cGAMP (c[G(2',5')pA(3',5')p], Cat. No. C 161)
• GpAp - Cat. No. G 056

Biolog sponsors the 5th International Meeting on Anchored cAMP Signaling Pathways which will be held October 6-9, 2016 in Zermatt, Switzerland.

Visit the meeting website at https://wp.unil.ch/akap2016/ for further information on this important event.

We are happy to introduce the new www.biolog.de to you. Our website has been completely revised to offer a fresh look, an extended search function for our products, and an improved online shop system.

If you are a registered user of www.biolog.de, please note that for the purpose of data protection, your address details and login information have not been transferred to the new website. We would therefore like to ask you to create a new online account.

Biolog sponsors the upcoming 22^nd International Round Table on Nucleosides, Nucleotides and Nucleic Acids (XXII IRT) (Paris/France, July 18 - 22, 2016, www.paris-irt2016.org).

Biolog sponsors the upcoming German Pharm-Tox Summit 2016 (DGPT) (Berlin/Germany, February 29 - March 3, 2016) and the Annual Conference of the Association for General and Applied Microbiology (VAAM) (Jena/Germany, March 13 - 16, 2016).

The cyclic dinucleotide 2'2'-cGAMP (c[A(2',5')pG(2',5')p], Cat. No. C 210) is now available from Biolog.

Similar to the metazoan second messenger 2'3'-cGAMP (Cat. No. C 161), 2'2'-cGAMP binds the signalling protein STING and subsequently induces type I interferons.

Latest additions to our product line of c-diAMP and c-diGMP-related cyclic dinucleotides:

• c[G(2',5')pG(3',5')p] / 2',5'-3',5'-c-diGMP - Cat. No. C 182
• c[A(2',5')pA(3',5')p] / 2',5'-3',5'-c-diAMP - Cat. No. C 187
• c[A(2',5')pA(2',5')p] / 2',5'-2',5'-c-diAMP - Cat. No. C 188
• 8,8'-Di-Chloro-c-diAMP - Cat. No. D 161

c-diAMP (Cat. No. C 088) and c-diGMP (Cat. No. C 057) are natural second messenger molecules playing fundamental roles in bacterial signalling.

We have updated the citation lists for our products 2'3'-cGAMP (Cat. No. C 161) and biotinylated 2'3'-cGAMP (Cat. No. C 176) with a study recently published in Science:

Bridgeman, A.; Maelfait, J.; Davenne, T.; Partridge, T.; Peng, Y.; Mayer, A.; Dong, T.; Kaever, V.; Borrow, P.; Rehwinkel, J., Science, 349, 1228 - 1232 (2015): "Viruses Transfer the Antiviral Second Messenger cGAMP Between Cells" - Link to PubMed

Biolog now offers a set containing 0.1 µmol each of c[G(2',5')pS-A(3',5')pS], isomer 1 and c[G(2',5')pS-A(3',5')pS], isomer 2 which are isomeric di-thiophosphate analogues of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka 2'3'-cGAMP, Cat. No. C 161). Please visit the product detail page for further information on the set.

We are pleased to announce a significant price reduction for our products pApA (Cat. No. P 033) and pGpG (Cat. No. P 023). These products are now sold in 1 µmol vials instead of 0.1 µmol vials at unchanged prices. Please visit the product detail pages for pApA and pGpG for further information.

The linear dinucleotides pApA and pGpG were found to be metabolic degradation products of the bacterial second messengers c-diAMP (Cat. No. C 088) and c-diGMP (Cat. No. C 057), respectively.

Together with academic collaborators, Biolog has developed new EPAC agonists that discriminate between the  isoforms EPAC1 and EPAC2. Two of the cyclic AMP-based structures described are now exclusively available from Biolog:

• Sp-8-BnT-cAMPS / "S-220" - Cat. No. B 046
• Sp-8-BnT-2'-O-Me-cAMPS / "S-223" - Cat. No. B 056.

Reference: Schwede, F. et al., PLoS Biol., 13(1):e1002038 (2015): "Structure-Guided Design of Selective Epac1 and Epac2 Agonists" (Link to PLoS Biology)