For other salt forms or higher purity please inquire. Hydrolysis-resistant slow binding inhibitor of ADP-ribosyl cyclase (i.e. CD 38). Detailed technical information available. References: Muller-Steffner et al., J. Biol. Chem., 267, 9606 - 9611 (1992); Berthelier et al., Biochem. J., 330, 1383 - 1390 (1998); Gerth et al., Biochem. J., 382, 849 - 856 (2004).
| Cat. No. | D 148 |
| CAS number | [133575-27-6] |
| Purity | > 97 % HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₂₁H₂₆FN₇O₁₃P₂ (free acid) |
| Molecular weight [g/mol] | 665.4 (free acid) |
| Absorption max [nm] | 260 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 20000 |
- 1. Gerth A., Nieber K., Oppenheimer N. J.Hauschildt S., Biochem. J., 382, 849 - 856 (2004), "Extracellular NAD+ Regulates Intracellular Free Calcium Concentration in Human Monocytes"
- 2. Berthelier V., Tixier J.-M., Muller-Steffner H. M., Schuber F.Deterre P., Biochem. J., 330, 1383 - 1390 (1998), "Human CD38 is an Authentic NAD(P)+ Glycohydrolase"
- 3. Muller-Steffner H. M., Malver O., Hosie L., Oppenheimer N. J.Schubert F., J. Biol. Chem., 267, 9606 - 9611 (1992), "Slow-Binding Inhibition of NAD+ Glycohydrolase by Arabino Analogues of Beta-NAD"
- 4. Rah S.-Y., Kwak J.-Y.Kim U.-H., Scientific Reports, 0, 0 - 0 (0), "ADP-Ribose/TRM2-mediated Ca2+ Signaling is Essential for Cytolytic Degranulation and Antitumor Activity of Natural Killer Cells"
