For other salt forms or higher purity please inquire. ADPRP is an analogue of adenosine-5'-O-diphosphoribose (ADP-ribose or ADPR) in which the ribose 2'-hydroxy group is phosphorylated; potential metabolite of NADP+ and β-NAADP (Cat. No. N 018). Detailed technical information available. References: Roitelman & Shechter, J. Lipid Res., 27, 828 - 835 (1986); Aarhus, R. et al., J. Biol. Chem., 270, 30327 - 30333 (1995); Schmid et al., FEBS Lett., 585, 3544 - 3548 (2011).
| Cat. No. | A 190 |
| CAS number | [53595-18-9] |
| Purity | > 95% HPLC |
| Salt form | Sodium |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₅H₂₄N₅O₁₇P₃ (free acid) |
| Molecular weight [g/mol] | 639.3 (free acid) |
| Absorption max [nm] | 259 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 15000 |
- 1. Schmid F., Bruhn S., Weber K., Mittrücker H.-W.Guse A. H., FEBS Lett., 585, 3544 - 3548 (2011), "CD38: A NAADP Degrading Enzyme"
- 2. Aarhus R., Graeff R. M., Dickey D. M., Walseth T. F.Lee H. C., J. Biol. Chem., 270, 30327 - 30333 (1995), "ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+"
- 3. Roitelman J.Shechter I., J. Lipid Res., 27, 828 - 835 (1986), "Allosteric and Non-allosteric Forms of Rat Liver 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase: Differential Inhibition of Activity by Adenosine 2'-monophospho-5'-diphosphoribose"
- 4. Bailey J. M.Colman F., Biochemistry, 24, 5367 - 5377 (1985), "Affinity Labeling of NADP+-Specific Isocitrate Dehydrogenase by a New Fluorescent Nucleotide Analogue 2-[(4-Bromo-2,3-dioxybutyl)thio]-1,N6-ethenoadenosine 2´,5´-Bisphosphate"
