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β-NAADP⁺

β- Nicotinic acid adenine dinucleotide phosphate ( β-NAADP⁺ ), sodium salt
Cat. No.: N 018
    
CAS No.: [5502-96-5]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: N 018-10
Unit: 10 µmol / ~7.4 mg
$165.00
For other salt forms or higher purity please inquire. β-NAADP+ is a potent stimulator of intracellular Ca2+ mobilization in a variety of cell types. Its function was first demonstrated in sea urchin egg homogenates. Detailed technical information available. References: Lee & Aarhus, J. Biol. Chem., 270, 2152 - 2157 (1995); Berg et al., J. Cell Biol., 150, 581 - 588 (2000); Schmid et al., FEBS Lett., 585, 3544 - 3548 (2011).
Cat. No. N 018
CAS number [5502-96-5]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -70°C / -94°F
Molecular formula C₂₁H₂₇N₆O₁₈P₃ (free acid)
Molecular weight [g/mol] 744,4 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 18000
  • 1. Schmid F., Bruhn S., Weber K., Mittrücker H.-W.Guse A. H., FEBS Lett., 585, 3544 - 3548 (2011), "CD38: A NAADP Degrading Enzyme"
  • 2. Rah S.-Y., Mushtaq M., Nam T.-S., Kim S. H.Kim U.-H., J. Biol. Chem., 285, 21877 - 21887 (2010), "Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+ Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells"
  • 3. Preugschat F., Tomberlin G. H.Porter D. J. T., Arch. Biochem. Biophys., 479, 114 - 120 (2008), "The Base Exchange Reaction of NAD+ Glycohydrolase: Identification of Novel Heterocyclic Alternative Substrates"
  • 4. Fliegert R.Guse A. H., Biochem. Soc. Trans., 35, 109 - 114 (2007), "Regulation of Calcium Signalling by Adenine-based Second Messengers"
  • 5. Dowden J., Berridge G., Moreau C., Yamasaki M., Churchill G. C., Potter B. V. L.Galione A., Chem. Biol., 13, 659 - 665 (2006), "Cell-Permeant Small-Molecule Modulators of NAADP-Mediated Ca2+ Release"
  • 6. Billington R. A., Bellomo E. A., Floriddia E. M., Erriquez J., Distasi C.Genazzani A. A., FASEB J., 20, 521 - 523 (2006), "A Transport Mechanism for NAADP in a Rat Basophilic Cell Line"
  • 7. Berg I., Potter B. V. L., Mayr G. W.Guse A. H., J. Cell. Biol., 150, 581 - 588 (2000), "Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP(+)) is an Essential Regulator of T-Lymphocyte Ca(2+)-Signaling"
  • 8. Aarhus R., Graeff R. M., Dickey D. M., Walseth T. F.Lee H. C., J. Biol. Chem., 270, 30327 - 30333 (1995), "ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+"
  • 9. Lee H. C.Aarhus R., J. Biol. Chem., 270, 2152 - 2157 (1995), "A Derivative of NADP Mobilizes Calcium Stores Insensitive to Inositol Trisphosphate and Cyclic ADP-Ribose"
  • 10. Chini E. N., Beers K. W.Dousa T. P., J. Biol. Chem., 270, 3216 - 3223 (1995), "Nicotinate Adenine Dinucleotide Phosphate (NAADP) Triggers a Specific Calcium Release System in Urchin Eggs"