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MANT-dGTP

2'- Deoxy- 3'- O- (N'- methylanthraniloyl)guanosine- 5'- O- triphosphate ( MANT-dGTP )
Fluorescent analogue of 2'-deoxy-GTP
Cat. No.: D 086
    
CAS No.: [124615-99-2]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: D 086-05
Unit: 5 µmol / ~3.2 mg
$175.00

For other salt forms please inquire. Fluorescent analogue of 2'-deoxyguanosine-5’-triphosphate (λexc 350 nm; λem 442 nm), useful for research into 5’-dGTP-dependent receptor proteins. The MANT fluorophore has a certain sensitivity for its environment and can change its spectral properties upon binding. Detailed technical information available. For reference compare: Hiratsuka, Biochim. Biophys. Acta, 742, 496 - 508 (1983).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. D 086
CAS number [124615-99-2]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Light-sensitive True
Molecular formula C₁₈H₂₃N₆O₁₄P₃ (free acid)
Molecular weight [g/mol] 640,3 (free acid)
Excitation max [nm] 350
Emission max [nm] 442
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 22600
UV pH value 8
  • 1. Seifert R.Dove S., Pharmacol. Therapeut., 140, 200 - 212 (2013), "Inhibitors of Bacillus anthracis Edema Factor"
  • 2. Wang J. L., Guo J.-X., Zhang Q.-Y., Wu J. J.-Q., Seifert R.Lushington G. H., Bioorg. Med. Chem., 15, 2993 - 3002 (2007), "A Conformational Transition in the Adenylyl Cyclase Catalytic Site Yields Different Binding Modes for Ribosyl-modified and Unmodified Nucleotide Inhibitors"
  • 3. Hiratsuka T., Biochim. Biophys. Acta, 742, 496 - 508 (1983), "New Ribose-modified Fluorescent Analogs of Adenine and Guanine Nucleotides Available as Substrates for Various Enzymes"