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Alternative structural projections:

MANT-cAMP

2'- O- (N'- Methylanthraniloyl)adenosine- 3', 5'- cyclic monophosphate, sodium salt ( MANT-cAMP )
Fluorescent, PKA-inactive analogue of cyclic AMP
Cat. No.: M 008
    
CAS No.: [83707-14-6]
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Product Name Price (net) Qty
Cat. No.: M 008-10
Unit: 10 µmol / ~4.8 mg
$180.00
For other salt forms, metabolites or anthraniloyl- cAMP please inquire. Fluorescent cyclic AMP analogue (λexc 350 nm, λem 445 nm), suitable for phosphodiesterase studies. The compound shows a decrease in fluorescence when cleaved by PDE. Detailed technical information available. References: Hiratsuka, J. Biol. Chem., 257, 13354 - 13358 (1982); Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001).
Cat. No. M 008
CAS number [83707-14-6]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₈H₁₈N₆O₇P · Na
Molecular weight [g/mol] 484,4
Modifications 2'-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.59
Absorption max [nm] 255/355
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 22200/ 5400
UV pH value 8
  • 1. Schweinsberg S., Moll D., Burghardt N. C., Hahnefeld C., Schwede F., Zimmermann B., Drewianka S., Werner L., Kleinjung F., Genieser H.-G., Schuchhardt J.Herberg F. W., Proteomics, 8, 1212 - 1220 (2008), "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
  • 2. Wang J. L., Guo J.-X., Zhang Q.-Y., Wu J. J.-Q., Seifert R.Lushington G. H., Bioorg. Med. Chem., 15, 2993 - 3002 (2007), "A Conformational Transition in the Adenylyl Cyclase Catalytic Site Yields Different Binding Modes for Ribosyl-modified and Unmodified Nucleotide Inhibitors"
  • 3. Moll D., Prinz A., Gesellchen F., Drewianka S., Zimmermann B.Herberg F. W., J. Neural. Transm., 113, 1015 - 1032 (2006), "Biomolecular Interaction Analysis in Functional Proteomics"
  • 4. Diaz-Benjumea R., Laxman S., Hinds T. R., Beavo J. A.Rascon A., Biochem. J., 399, 305 - 314 (2006), "Characterization of a Novel cAMP-binding, cAMP-specific Cyclic Nucleotide Phosphodiesterase (tcrPDEB1) from Trypanosoma Cruzi"
  • 5. Hahnefeld C.Herberg F. W., Abstract of the 13th Protein Kinase Symposium p. 14, 0, 12 - 15 (2002), "cAMP-dependent Protein Kinase: cAMP Analog Screening Using Surface Plasmon Resonance and Fluorescent Methods"
  • 6. Kraemer A., Rehmann H., Cool R. H., Theiss C., de Rooij J., Bos H.Wittinghofer A., J. Mol. Biol., 306, 1167 - 1177 (2001), "Dynamic Interaction of cAMP with the Rap Guanine-nucleotide Exchange Factor Epac1"
  • 7. Hiratsuka T., J. Biol. Chem., 257, 13354 - 13358 (1982), "New Fluorescent Analogs of cAMP and cGMP Available as Substrates for Cyclic Nucleotide Phosphodiesterase"