According to Tsalkova et al. (2012) ESI-05 is a membrane-permeant selective inhibitor of Epac 2. Detailed technical information available. Reference: Tsalkova et al., Proc. Natl. Acad. USA, 109, 18613 - 18618 (2012).
| Cat. No. | M 092 |
| CAS number | [5148-64-5] |
| Purity | > 95% HPLC |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₆H₁₈O₂S |
| Molecular weight [g/mol] | 274.4 |
| Target | Epac Inhibitor |
| Absorption max [nm] | 244 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 19000 |
- 1. Henquin J.-C.Nenquin M., Endocrinol., 0, 0 - 0 (2014), "Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+ in Female Mouse Islets Stimulated by Glucose and Tolbutamide"
- 2. Rehmann H., Sci. Rep., 3: 3032, 0, 0 - 0 (2013), "Epac-Inhibitors: Facts and Artefacts"
- 3. Tsalkova T., Mei F. C., Li S., Chepurny O. G., Leech C. A., Liu T., Holz G. G., Woods V. L.Cheng X., Proc. Natl. Acad. Sci. USA, 109, 18613 - 18618 (2012), "Isoform-Specific Antagonists of Exchange Proteins Directly Activated by cAMP"
