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DB-cAMP-AM

N6, 2'- O-Dibutyryladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester (DB-cAMP-AM)

Metabolically activatable prodrug form of dibutyryl cAMP
Cat. No.: D 008
    
CAS No.: [159910-48-2]
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Product Name Price (net) Qty
Cat. No.: D 008-01
Unit: 1 µmol / ~0.5 mg
$125.00
Highly potent and membrane-permeant precursor of DB-cAMP. Releases dibutyryl cAMP after metabolic activation by esterases. Due to further degradation to the much more polar monobutyryl cAMP and cAMP the kinase activators are trapped inside the cell. Detailed technical information and references available. Reference: Schultz et al., J. Biol. Chem., 268, 6316 - 6322 (1993).
Caution: This analogue releases butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects!
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. D 008
CAS number [159910-48-2]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₂₁H₂₈N₅O₁₀P
Molecular weight [g/mol] 541,5
Modifications 2'-cAMP
Target PKA (cAK) Activator
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000