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Peptide-based, membrane permeant inhibitor of protein kinase G type Iα and Iβ. Detailed technical information available. Reference: Dostmann et al., Proc. Natl. Acad. Sci. USA, 97, 14772 - 14777 (2000). Biolog also offers the controlpeptide W45 (Cat. No. W 001).
Cat. No.
D 051
CAS number
[pending]
Purity
> 95% HPLC
Salt form
TFA
Storage temperature
-20°C / -4°F
Molecular formula
C₁₂₂H₂₂₃N₅₃O₂₃
Molecular weight [g/mol]
2800.5 for free peptide
1. Nickl C. K., Raidas S. K., Zhao H., Sausbier M., Ruth P., Tegge W., Brayden J. E.Dostmann W. R. G., Biochim. Biophys. Acta, 1804, 524 - 532 (2010), "(D)-Amino Acid Analogues of DT-2 as Highly Selective and Superior Inhibitors of cGMP-dependent Protein Kinase I alpha"
3. Pinkse M. W. H., Rijkers D. T. S., Dostmann W. R.Heck A. J. R., J. Bio. Chem., 284, 16354 - 16368 (2009), "Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry"
4. Lohmann S. M.Walter U., Frontiers Biosci., 10, 1313 - 1328 (2005), "Tracking Functions of cGMP-dependent Protein Kinase"
5. Taylor M. S., Okwuchukwuasanya C., Nickl C. K., Tegge W., Brayden J. E.Dostmann W. R. G., Mol. Pharmacol., 65, 1111 - 1119 (2004), "Inhibition of cGMP-dependent Protein Kinase by the Cell-permeable Peptide DT-2 Reveals a Novel Mechanism of Vasoregulation"
6. Dostmann W. R. G., Tegge W., Frank R., Nickl C. K., Taylor M. S.Brayden J. E., Pharmacol. Ther., 93, 203 - 215 (2002), "Exploring the Mechanisms of Vascular Smooth Muscle Tone with Highly Specific, Membrane-permeable Inhibitors of Cyclic GMP-dependent Protein Kinase I Alpha"
7. Scholten A., Pinkse M. W. H., Maier C. S.Dostmann W. R. G., Abstract of the 13th Protein Kinase Symposium p. 29, 0, 12 - 15 (2002), "Probing Non-covalent Protein-Ligand Interactions of cGMP-dependent Protein Kinase by Nanoflow ESI Orthogonal Time of Flight MS"
8. Dostmann W. R. G., Nickl C. K., Taylor M. S., Brayden J. E., Frank R.Ten Eyck L. F., Cell. Biol. Mol. Lett., 6, 458 - 458 (2001), "Highly Specific and Membrane Permeant Peptide Inhibitors of cGMP-Dependent Protein Kinase I alpha"
9. Dostmann W. R. G., Taylor M. S., Nickl C. K., Brayden J. E., Frank R.Tegge W., Proc. Natl. Acad. Sci. U.S.A., 97, 14772 - 14777 (2000), "Highly Specific, Membrane-permeant Peptide Blockers of cGMP-dependent Protein Kinase I Alpha Inhibit NO-induced Cerebral Dilation"