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(D)-DT-2

PKG inhibitor peptide (D)-DT-2
Potent peptide-based inhibitor of protein kinase G I α and I β
Cat. No.: D 110
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: D 110-005
Unit: 0.5 mg / ~0.18 µmol
$248.00
Proteolytically resistant, membrane permeant and highly potent peptide-based inhibitor of protein kinase G type I α and I β. Detailed technical information available. Reference: Nickl et al., Biochim. Biophys. Acta, 1804, 524 - 532 (2010). Biolog also offers the control peptide W45 (Cat. No. W 001).
Cat. No. D 110
CAS number [pending]
Purity > 95% HPLC
Salt form TFA
Storage temperature -20°C / -4°F
Molecular formula C₁₂₂H₂₂₃N₅₃O₂₃
Molecular weight [g/mol] 2800,5 for free peptide
  • 1. Gambaryan S., Butt E., Kobsar A., Geiger J., Rukoyatkina N., Parnova R., Nikolaev V. O.Walter U., Br. J. Pharmacol., 167, 1476 - 5381 (2012), "The Oligopeptide DT-2 is a Specific PKG I Inhibitor only In Vitro, not in Living Cells"
  • 2. Gambaryan S., Butt E., Geiger J., Lohmann S. M.Walter U., BMC Pharmacol., Suppl. 1, P27, 11, 0 - 0 (2011), "Specific PKG Inhibitors: Do They Really Exist?"
  • 3. Nickl C. K., Raidas S. K., Zhao H., Sausbier M., Ruth P., Tegge W., Brayden J. E.Dostmann W. R. G., Biochim. Biophys. Acta, 1804, 524 - 532 (2010), "(D)-Amino Acid Analogues of DT-2 as Highly Selective and Superior Inhibitors of cGMP-dependent Protein Kinase I alpha"
  • 4. Koika V., Zhou Z., Vasileidis I., Roussos C., Finetti F., Monti M., Morbidelli L.Papapetropoulos A., Vasc. Pharmacol., 53, 215 - 222 (2010), "PKG-I Inhibition Attenuates Vascular Endothelial Growth Factor-stimulated Angiogenesis"