0 Items - $0.00
Categories
A to Z

4-MB-cCMP

N⁴- Monobutyrylcytidine- 3', 5'- cyclic monophosphate ( 4-MB-cCMP ), sodium salt
Cat. No.: M 075
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: M 075-05
Unit: 5 µmol / ~2 mg
$218.00

For other salt forms please inquire. 4-MB-cCMP is an analogue of the putative second messenger nucleotide cCMP (Cat. No. C 001) and main cellular metabolite of DB-cCMP (Cat. No. D 075), generated by unspecific esterases attacking the 2'-O-butyryl group of DB-cCMP. 4-MB-cCMP was found to be a low-potency partial activator of PKG Iα both in vitro and in vivo. It was also reported to display full and moderate activation of PKA RIα and PKA RIIα in vitro, while showing no evidence for PKA activation in vivo. Detailed technical information available. Reference: Wolter et al., Naunyn Schmiedebergs Arch. Pharmacol., 387, 1163 - 1175 (2014).

Cat. No. M 075
CAS number [pending]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₇N₃O₈P · Na
Molecular weight [g/mol] 397,3
Lipophilicity 1.74
Absorption max [nm] 248
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16400
  • 1. Wolter S., Dove S., Golombek M., Schwede F.Seifert R., Naunyn-Schmiedeberg's Arch. Pharmacol., 387, 1163 - 1175 (2014), "N4-monobutyryl-cCMP Activates PKA RIalpha and PKA RIIalpha more Potently and with Higher Efficacy than PKG Ialpha in Vitro but not in Vivo"